Pregabalin induced reproductive toxicity and body weight changes by affecting caspase3 and leptin expression: Protective role of wheat germ oil

Shokry, Dina A.; Nabrawy, Naglaa El; Yassa, Hanan Dawood; Batiha, Gaber El‐Saber; Welson, Nermeen N.

doi:10.1016/j.lfs.2020.118344

Cited by 8 publications

(6 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The authors attributed the weight loss to the striking lack of interest in their food intake. Also, Shokry et al confirmed the previous findings (Shokry et al 2020 ).…”

Section: Discussionsupporting

confidence: 73%

“…From our experience at the Toxicology Unit, Mansoura University Emergency Hospital, many cases presented with an acute overdose of pregabalin who reported a history of regular chronic use of pregabalin. In April 2019, the Egyptian authorities added pregabalin to the controlled medication list (Shokry et al 2020 ). Moreover, the European Union added a warning regarding its misuse to the Summary of Product Characteristics (Evoy et al 2017 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Comparative Study of the Neurotoxic Effects of Pregabalin Versus Tramadol in Rats

et al. 2022

View full text Add to dashboard Cite

In Egypt, both pregabalin and tramadol misuse increased in the last decade. Although many studies have confirmed the neurotoxic effects of tramadol, those of pregabalin are understudied. The aim of the study is to evaluate the neurotoxic effects of pregabalin compared with tramadol. Thirty male albino rats were included in this experimental study, and they were randomly allocated into three equal groups: group I (normal saline), group II (tramadol misuse), and group III (pregabalin misuse). All rats received the commenced drugs for 1 month. Open field tests were performed on the day of scarification, and after that, cortical samples were taken for immunohistochemical analysis and quantification of dopamine receptors’ gene expression. The drug misuse groups showed a significant decrease in weight gain at the end of the study. Open field testing showed the upper hand of controls regarding all of the tested parameters. Tramadol has a more negative impact on the locomotor parameters compared with pregabalin. Both drugs induced relatively low dopamine-1 receptor (D1Rs) expression to dopamine-2 receptors (D2Rs), mimicking the schizophrenia model. Both tramadol and pregabalin were associated with neurotoxic effects in male albino rats. These effects were less noticed with pregabalin. It is suggested that long-term abuse may end in psychosis.

show abstract

“…The authors attributed the weight loss to the striking lack of interest in their food intake. Also, Shokry et al confirmed the previous findings (Shokry et al 2020 ).…”

Section: Discussionsupporting

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Comparative Study of the Neurotoxic Effects of Pregabalin Versus Tramadol in Rats

et al. 2022

View full text Add to dashboard Cite

show abstract

“…To guarantee the biosafety of probes for use in vivo, the biocompatibility of mPT was evaluated via a hemolysis assay. The hemolysis ratio was below 10%, which was acceptable according to previous reports. , The hemolysis ratio of red cells was below 4% with different concentrations of mPT, indicating the satisfactory hemocompatibility of mPT (Figure a). Motivated by the good photothermal performance, the potential of mPT as NIR and PAI agents for imaging in vivo was evaluated in 4T1 tumor-bearing mice.…”

Section: Resultsmentioning

confidence: 99%

Binary Pt/Te Nanoheterostructures with High Photothermal Conversion Efficiency and Anti-inflammatory Action for Enhanced Photothermal Therapy of 4T1 Breast Tumors Guided by Photoacoustic Imaging

Hou

Jiang

et al. 2022

ACS Sustainable Chem. Eng.

View full text Add to dashboard Cite

Photothermal therapy is a powerful candidate for tumor treatment. However, photothermal therapy still faces some challenges, such as lacking photothermal agents with high photothermal conversion efficiency and undesirable inflammatory responses, which may result in tumor recurrence and therapeutic resistance. Here, the Pt/Te nanoheterostructures (PT) were synthesized by a simple hydrothermal reaction. The photothermal conversion efficiency was up to 51.84%. The outstanding photothermal conversion capacity of PT was attributed to the unique localized surface plasmon resonance frequency of metals and semiconductors and the increased circuit paths of electron transitions from nanoheterostructures. After coating with the murine mammary carcinoma (4T1) cell membrane, the camouflaged PT (mPT) exhibits excellent biocompatibility and effective homologous targeting capacity. Benefiting from antioxidative activity, mPT can efficiently scavenge inflammation-related reactive oxygen species and cytokines (such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6) caused by hyperthermia to alleviate inflammation in vitro and in vivo. The in vitro and in vivo therapeutic results showed that mPT could effectively inhibit 4T1 breast tumors. In addition, the in vivo therapy could be guided by photoacoustic imaging. These results demonstrated that these multifunctional mPT provide a paradigm for biomimetic metal and semiconductor nanoheterostructures for enhanced photothermal therapy and anti-inflammatory action on tumors.

show abstract

“…The use of common clinical drugs may lead to changes in the testicular microenvironment and thus affect spermatogenesis. In animal studies, it was found that bupropion ( Yardimci et al, 2019 ), paroxetine ( Erdemir et al, 2014 ; Yakubu and Atoyebi., 2018 ; Yardimci et al, 2019 ), benzodiazepines ( Chengelis et al, 1986 ; Means et al, 1982 ), nifedipine ( Iranloye et al, 2009 ; Lee et al, 2006 ), ethosuximide ( Lee et al, 2006 ), valproate ( Alsemeh et al, 2022 ; Nishimura et al, 2000 ; RØste et al, 2001 ; Sukhorum and Lamsaard., 2017 ), pregabalin ( Shokry et al, 2020 ; Taha et al, 2020 ), rosuvastatin ( Leite et al, 2017 ), etc., had negative effects on the testicular microenvironment. Antidepressant bupropion can cause testicular structural damage and interstitial edema ( Yardimci et al, 2019 ).…”

Section: Main Textmentioning

confidence: 99%

“…And another type of AEDs Pregabalin can reduce the number of germ cells while increasing the number of interstitial cells, and cause a decrease in the number and diameter of convoluted tubules ( Salem et al, 2020 ). It also induces cell apoptosis, increases caspase-3 expression in the testis ( Shokry et al, 2020 ), upregulates pro-apoptotic genes BAX and p38 MAPK, and downregulates the anti-apoptotic gene BCL2 ( Taha et al, 2020 ). The reproductive toxicity of pregabalin may be related to the p38 MAPK and BAX/BCL2 signaling pathways ( Taha et al, 2020 ).…”

Section: Main Textmentioning

confidence: 99%

Effects of clinical medications on male fertility and prospects for stem cell therapy

Mo,

Zhao,

et al. 2023

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

An increasing number of men require long-term drug therapy for various diseases. However, the effects of long-term drug therapy on male fertility are often not well evaluated in clinical practice. Meanwhile, the development of stem cell therapy and exosomes treatment methods may provide a new sight on treating male infertility. This article reviews the influence and mechanism of small molecule medications on male fertility, as well as progress of stem cell and exosomes therapy for male infertility with the purpose on providing suggestions (recommendations) for evaluating the effect of drugs on male fertility (both positive and negative effect on male fertility) in clinical application and providing strategies for diagnosis and treatment of male infertility.

show abstract

Pregabalin induced reproductive toxicity and body weight changes by affecting caspase3 and leptin expression: Protective role of wheat germ oil

Cited by 8 publications

References 39 publications

Comparative Study of the Neurotoxic Effects of Pregabalin Versus Tramadol in Rats

Comparative Study of the Neurotoxic Effects of Pregabalin Versus Tramadol in Rats

Binary Pt/Te Nanoheterostructures with High Photothermal Conversion Efficiency and Anti-inflammatory Action for Enhanced Photothermal Therapy of 4T1 Breast Tumors Guided by Photoacoustic Imaging

Effects of clinical medications on male fertility and prospects for stem cell therapy

Contact Info

Product

Resources

About