Seven lanthanide-cobalt heterometallic three-dimensional coordination polymers: {[Ln(3)Co(2)(BPDC)(5)(HBPDC)(H(2)O)(5)](ClO(4))(2)·mH(2)O}(n) (Ln = Eu (1, m = 10.25), Gd (2, m = 8), Tb (3, m = 9.5), Dy (4, m = 11), Ho (5, m = 10.5), Tm (6, m = 11), Lu (7, m = 10.25); BPDC = 5,5'-dicarboxylate-2,2'-dipyridine anion) were structurally and magnetically characterized. Compounds 1-7 crystallize in the orthorhombic space group Pbca, featuring a 3D sandwich framework. Magnetic properties of 2-6 have been investigated by using DC (direct current) and AC (alternating current) susceptibility measurements. Among these compounds, only compound 4 displays significant frequency dependence, albeit without reaching the characteristic maxima above 2 K, implying slow magnetic relaxation behavior in 4. After the application of a DC field, good peak shapes of AC signals were obtained and the energy barrier ΔE/k(B) = 62.89 K and the preexponential factor τ(0) = 6.16 × 10(-8) s. To our knowledge, 4 has the highest energy barrier in Ln-Co SMM systems hitherto.
Photothermal therapy is a powerful candidate for tumor
treatment.
However, photothermal therapy still faces some challenges, such as
lacking photothermal agents with high photothermal conversion efficiency
and undesirable inflammatory responses, which may result in tumor
recurrence and therapeutic resistance. Here, the Pt/Te nanoheterostructures
(PT) were synthesized by a simple hydrothermal reaction. The photothermal
conversion efficiency was up to 51.84%. The outstanding photothermal
conversion capacity of PT was attributed to the unique localized surface
plasmon resonance frequency of metals and semiconductors and the increased
circuit paths of electron transitions from nanoheterostructures. After
coating with the murine mammary carcinoma (4T1) cell membrane, the
camouflaged PT (mPT) exhibits excellent biocompatibility and effective
homologous targeting capacity. Benefiting from antioxidative activity,
mPT can efficiently scavenge inflammation-related reactive oxygen
species and cytokines (such as tumor necrosis factor (TNF)-α,
interleukin (IL)-1β, and IL-6) caused by hyperthermia to alleviate
inflammation in vitro and in vivo. The in vitro and in vivo therapeutic
results showed that mPT could effectively inhibit 4T1 breast tumors.
In addition, the in vivo therapy could be guided by photoacoustic
imaging. These results demonstrated that these multifunctional mPT
provide a paradigm for biomimetic metal and semiconductor nanoheterostructures
for enhanced photothermal therapy and anti-inflammatory action on
tumors.
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