Binary Pt/Te Nanoheterostructures with High Photothermal Conversion Efficiency and Anti-inflammatory Action for Enhanced Photothermal Therapy of 4T1 Breast Tumors Guided by Photoacoustic Imaging

Abstract

Photothermal therapy is a powerful candidate for tumor treatment. However, photothermal therapy still faces some challenges, such as lacking photothermal agents with high photothermal conversion efficiency and undesirable inflammatory responses, which may result in tumor recurrence and therapeutic resistance. Here, the Pt/Te nanoheterostructures (PT) were synthesized by a simple hydrothermal reaction. The photothermal conversion efficiency was up to 51.84%. The outstanding photothermal conversion capacity of PT was attributed to the unique localized surface plasmon resonance frequency of metals and semiconductors and the increased circuit paths of electron transitions from nanoheterostructures. After coating with the murine mammary carcinoma (4T1) cell membrane, the camouflaged PT (mPT) exhibits excellent biocompatibility and effective homologous targeting capacity. Benefiting from antioxidative activity, mPT can efficiently scavenge inflammation-related reactive oxygen species and cytokines (such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6) caused by hyperthermia to alleviate inflammation in vitro and in vivo. The in vitro and in vivo therapeutic results showed that mPT could effectively inhibit 4T1 breast tumors. In addition, the in vivo therapy could be guided by photoacoustic imaging. These results demonstrated that these multifunctional mPT provide a paradigm for biomimetic metal and semiconductor nanoheterostructures for enhanced photothermal therapy and anti-inflammatory action on tumors.

Glutathione-Activated In Situ Transformation of Nanosized Vanadium Oxides for Postoperative Precision Tumor Theranostics

“…In order to effectively convert light into a substantial amount of heat energy, it is vital to have strong NIR absorption. − The GSH-responsive enhancement of absorption at 808 nm makes the transformation of HA@V 2 O 5 NPs to HA@VO x NPs possible to be applied for GSH-activated PTT. To prove this expectation, the GSH-activated photothermal property of HA@V 2 O 5 NPs was primarily assessed.…”

Ionic Functionalized Magnetic Porous Polymers as Advanced Materials for High-Efficiency Water Decontamination: Bactericidal and Iodine Adsorption

“…The temperature evolution profiles (Figure d,e) revealed the powder-dependent warming behavior of FP-POP and iFP-POP. With varying laser power from 0.5 to 2.0 W cm –2 , the temperature of iFP-POP drastically increased from 45.5 to 74.5 °C, higher than that of FP-POP (from 40.3 to 70.6 °C) . Subsequently, the temperature changes in a continuous warming–cooling process were examined for FP-POP (200 μg mL –1 ) and iFP-POP (200 μg mL –1 ).…”

“…With varying laser power from 0.5 to 2.0 W cm −2 , the temperature of iFP-POP drastically increased from 45.5 to 74.5 °C, higher than that of FP-POP (from 40.3 to 70.6 °C). 47 Subsequently, the temperature changes in a continuous warming−cooling process were examined for FP-POP (200 μg mL −1 ) and iFP-POP (200 μg mL −1 ). According to the cooling stages of FP-POP and iFP-POP, the curves of cooling time versus negative natural logarithm of the temperature driving force (−ln θ) were calculated.…”

Anti-inflammatory strategies for photothermal therapy of cancer

“…7B). 117 The nanoparticles were wrapped by cancer cell membranes to enhance active targeting and biocompatibility. The nanoparticles with oxidative activity could forcefully scavenge inflammation-related ROS and cytokines induced by PTT, thereby relieving inflammation in vitro and in vivo .…”