Platelet-rich Plasma and Platelet-rich fibrin in human cell culture

Platelet Rich Fibrin: A Novel Approach for Osseous Regeneration

“…Healing in tissues is mediated by variety of signalling proteins. Understanding of this process at microcellular level is still not complete, but it is proven fact that platelets do play an important role in wound healing [1]. Platelet rich plasma is an autologous concentration of human platelets in small volume of plasma and it contains seven fundamental protein growth factors [2].…”

Platelet Concentrates: Past, Present and Future

“…Additional randomized, controlled clinical trials are warranted to test the long term benefits and ultimate surgical outcomes associated with PRP and FS [2,17]. As with PRF, though this biomaterial appears to accelerate physiologic healing, the numerous perspectives of PRF have still to be clinically tested [1].…”

“…Understanding the entire process is still incomplete. However, it is known that platelets play a crucial role not only in hemostasis, but also in the wound healing process [2].…”

“…Once bound, intracellular signal proteins are activated. This results in the expression of a gene sequence that directs cellular proliferation, collagen synthesis, osteoid production, and so on [2].…”

Alveolar Bone Expansion for Implant Placement in Compromised Aesthetic Zone – Case Series

“…The presence of cytokines within the fibrin mesh allows for their progressive release over time period of 7-11 days which is the life span of platelet following which the network of fibrin disintegrates [4]. The PRF membrane acts like a fibrin bandage [5], which significantly serves as a matrix to accelerate the healing of the wound edges and surfaces [6]. The PRF provides post-operative protection to dentistry section aBstRaCt Implant placement and restoration of compromised alveolar ridges in the aesthetic zone has always been a challenge to the oral implantologists.…”