Platelet Rich Fibrin: A Novel Approach for Osseous Regeneration

AimTo analyse the effect of leucocyte‐ and platelet‐rich fibrin (L‐PRF) on bone regeneration procedures and osseointegration.Materials and MethodsAn electronic and hand search was conducted in three databases (MEDLINE, EMBASE and Cochrane). Only randomized clinical trials, written in English where L‐PRF was applied in bone regeneration and implant procedures, were selected. No follow‐up restrictions were applied.ResultsA total of 14 articles were included and processed. Three subgroups were created depending on the application: sinus floor elevation (SFE), alveolar ridge preservation and implant therapy. In SFE, for a lateral window as well as for the trans‐alveolar technique, histologically faster bone healing was reported when L‐PRF was added to most common xenografts. L‐PRF alone improved the preservation of the alveolar width, resulting in less buccal bone resorption compared to natural healing. In implant therapy, better implant stability over time and less marginal bone loss were observed when L‐PRF was applied. Meta‐analyses could not be performed due to the heterogeneity of the data.ConclusionsDespite the lack of strong evidence found in this systematic review, L‐PRF might have a positive effect on bone regeneration and osseointegration.

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“…A better soft tissue healing and less post‐extraction pain was frequently reported (Singh et al. 2012, Hauser et al. 2013, Kumar et al.…”

Section: Resultsmentioning

confidence: 99%

Regenerative potential of leucocyte‐ and platelet‐rich fibrin. Part B: sinus floor elevation, alveolar ridge preservation and implant therapy. A systematic review

Castro

Meschi

Temmerman

et al. 2017

J Clinic Periodontology

144

133

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“…The same authors found that the use of PRF in the socket reduced the periodontal pocket depth. In another clinical study by Singh et al 13 improved healing of both soft tissue and bone was observed. Kumar et al 17 also concluded that PRF improved healing of both soft and hard tissue.…”

Section: Discussionmentioning

confidence: 88%

“…Ozgul et al 10 also investigated the efficacy of PRF in the reduction of pain and swelling after impacted third molar surgery, and they reported more swelling in the control group on the third postoperative day; however, there was no significant difference regarding pain between the groups. Singh et al 13 also indicated that the use of PRF did not reduce postoperative pain. In the present study, we did not find significant differences between the two groups regarding pain, swelling, and trismus.…”

Section: Discussionmentioning

confidence: 99%

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Trombositten zengin fibrinin gömülü yirmi yaş dişi cerrahisi sonrası postoperatif komplikasyonların azaltılmasına etkisi: prospektif, randomize kontrollü klinik araştırma

Esen¹,

Menziletoğlu²,

Işık³

2016

Acta Odontologica Turcica

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“…Platelet-Rich Fibrin (PRF) retains the growth factors enmeshed in the fibrin network, and enables their sustained release over a period of time, which can accelerate healing. In the recent years, better understanding of the physiologic properties of platelets in the healing process has led to their increased use in therapeutic applications, such as the treatment of vascular ulcers (20), bone regeneration (21), periodontal regeneration (22) and wound closure procedures (23). In view of these applications, we began to treat complex perianal fistulas by sealing them with PRF.…”

Section: Discussionmentioning

confidence: 99%

Method for Management of Perianal Fistula with New Device: Progressive Curettage of the Tract and Sealing with Platelet-Rich Fibrin

Lara¹,

Berges²,

González³

et al. 2016

Ann Colorectal Res

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Surgical treatment of high perianal fistulas, which affect a significant proportion of the sphincter apparatus, is difficult and associated with considerable risk of impaired anal continence. The diversity of approaches proposed for the treatment of complex perianal fistulas reflects the fact that no method has yet been shown to be fully satisfactory. We believe the successful treatment of this condition is directly proportional to the amount of fibrous tissue that can be removed. We used a kit of small curettes, of different thicknesses and sizes, incorporating spicules that enable the physician to remove fibrous tissue from the fistula tract. The small size and varying thicknesses of the curettes enable them to mold to the curves of the fistula tract and to remove tissue by de-roofing from the shallowest to the deepest layers, thus excising the entire fibrous tract. The tract is then sealed using autologous fibrin, applied through a catheter, with the help of a monitor indicating the amount of product remaining at all times. Finally, the internal orifice is closed by simple suturing.

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Platelet Rich Fibrin: A Novel Approach for Osseous Regeneration

Cited by 115 publications

References 15 publications

Regenerative potential of leucocyte‐ and platelet‐rich fibrin. Part B: sinus floor elevation, alveolar ridge preservation and implant therapy. A systematic review

Regenerative potential of leucocyte‐ and platelet‐rich fibrin. Part B: sinus floor elevation, alveolar ridge preservation and implant therapy. A systematic review

Trombositten zengin fibrinin gömülü yirmi yaş dişi cerrahisi sonrası postoperatif komplikasyonların azaltılmasına etkisi: prospektif, randomize kontrollü klinik araştırma

Method for Management of Perianal Fistula with New Device: Progressive Curettage of the Tract and Sealing with Platelet-Rich Fibrin

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