Physiologically-based pharmacokinetic modelling of distribution, bioaccumulation and excretion of POPs in Greenland sledge dogs (Canis familiaris)

Determination of plasma concentrations of organochlorine pesticides and polychlorinated biphenyls in pet cats and dogs

“…The OCPs and PCBs are the most prominent POPs in the environment, and because of their persistence, they have high bioaccumulation and biomagnification potential in wild and domestic organisms. Some OCPs and PCBs can persist in the environment for years and can be observed at 70,000 times higher levels in mammals compared against enviromental samples (Ritter et al, 1995; Sonne et al, 2015). Pet cats and dogs are exposed to OCPs and PCBs in both indoor and outdoor environments and in their feed.…”

“…The mean total serum concentration for the 19 PCBs was 2.799 ± 0.944 ng mL −1 . In addition, Sonne et al (2015) measured the concentrations of seven POPs, including HCB, 4,4-DDE, PCB-153 and PCB-99, in the plasma and tissue samples of Greenland sled dogs to create a PBPK (physiologically based pharmacokinetic) model to determine the distribution, bioaccumulation and elimination of these contaminants. Plasma levels of HCB, 4,4-DDE, PCB-153 and PCB-99 were 0.75, 3.60, 2.92 and 0.55 ng g −1 lw, respectively.…”

“…Therefore, the manufacture of most OCPs and PCBs has been banned or restricted worldwide. However, because of the persistence of these chemicals in the environment, they continue to be detected in recent studies performed in various countries (Braouezec et al, 2016; Das et al, 2017; Norrgran Engdahl et al, 2017; Ruiz-Suárez et al, 2015; Sonne et al, 2015). Furthermore, it was reported that the environmental levels of PCBs have risen in recent years in some regions (Ruiz-Suárez et al, 2016).…”

A risk assessment review of mercury exposure in Arctic marine and terrestrial mammals

“…Bradley et al, 2018;Kirkegaard et al, 2010aKirkegaard et al, , 2010bKirkegaard et al, , 2011Pedersen et al, 2015;Rogstad et al, 2017;Sonne, 2010;Sonne et al, 2005Sonne et al, , 2006aSonne et al, , 2006bSonne et al, , 2006cSonne et al, , 2007aSonne et al, , 2007bSonne et al, , 2007cSonne et al, , 2008aSonne et al, , 2008bSonne et al, , 2008cSonne et al, , 2008dSonne et al, , 2008e, 2009aSonne et al, , 2009bSonne et al, , 2010bSonne et al, , 2014aSonne et al, , 2014bSonne et al, , 2017Verreault et al, 2008). Other examples effect evaluation is the use of Risk Quotients comparing body burden and critical body residues estimated from PBPK modelling from rats and mice relative to immunologic, reproductive and carcinogenic effects, but such studies does not provide a better and more relevant picture relative to population effect of Arctic species in focus of this assessment (Sonne et al, 2009c(Sonne et al, , 2015(Sonne et al, , 2016Dietz et al, 2015Dietz et al, , 2018a. Observed effects in the HRC included potential for organ lesions (kidney, liver), anorexia, and reduced growth, while effects in the SRC included severe impacts on organ function (i.e.…”

Five Decades of Information on Canine Environmental Pollutant Exposure: A Scientometric Analysis

“…It should be emphasized in the development of this type of studies and the in uential role of the respective research teams in the development of these topics. Among them,Sonne et al 2010Sonne et al , 2011Sonne et al , 2015; Letcher et al 2009, 2017; Mizukawa and Nomiyama 2020, Poma et al 2020 and Pastorinho and Sousa, 2020 draw attention, because they focus their studies speci cally on the effect and relationship that canines exposed to different emerging environmental pollutants such as heavy metals, halogenated organic compounds and aromatic hydrocarbons would have on different biomarkers, including on the response of immunological, hepatorenal biomarkers and some endocrine parameters (Hansmann et al 2009; Chung et al 2020). In the same way, the role of Asian research that has allowed important advances in recent years in relation to these issues stands out, such as the research contributed by Zhang, Wang and Chen which has addressed important issues such as water quality, biological pollutants, air pollution, gastric toxins, among others (Wang et al 2010, 2020; Zhang et al 2019; Chen et al 2021), investigations that clarify much better the knowledge gaps on these issues as previously discussed, allowing broadening the spectrum of study of environmental pollutants in relation to canines, all of the above through the use of methodologies applied to omics sciences, a eld of study less studied in developing countries (Álvarez et al 2021) .…”