Photomagnetic Prussian blue nanocubes: Synthesis, characterization, and biomedical applications

Dumani, Diego S.; Cook, Jason R.; Kubelick, Kelsey P.; Luci, Jeffrey J.; Emelianov, Stanislav

doi:10.1016/j.nano.2019.102138

Cited by 16 publications

(15 citation statements)

References 61 publications

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“…Our prior work evaluated PBNC synthesis, optical and magnetic properties, and multimodal contrast of PBNC-labeled stem cells in vitro. 10 Our earlier ex vivo studies in excised spinal cords validated PA/MR agreement. 4 However, in vivo translation is faced with many challenges by attempting to add US/PA to a complex, risky surgical procedure, which is further magnified by motion, background signals, increased imaging depth, and the need for fast image acquisition, among many other factors.…”

Section: Introductionsupporting

confidence: 53%

“…S1) were synthesized in-house using methods described elsewhere. 10 Briefly, reactant and catalyst solutions were prepared in advance; they consisted of 5% potassium hexacyanoferrate (II) trihydrate by mass in deionized ultrafiltered (DIUF) water and 1.85% HCl in DIUF water, respectively. SPIONs (Ocean Nanotech; 60 mg) were added to 150 mL of DIUF water.…”

Section: Synthesis Of Prussian Blue Nanocubesmentioning

confidence: 99%

“…10,11 The material composition of PBNCs results in PA and MR imaging contrast. 10,12 Thus, US/PA imaging can be used for intraoperative guidance of PBNC-labeled stem cell injection and delivery followed by MRI for postoperative verification and longitudinal monitoring. 4,13 The high resolution and contrast, fast image acquisition, small footprint, portability, relatively low cost, and operating room compatibility make US/PA imaging ideal for intraoperative use.…”

Section: Introductionmentioning

confidence: 99%

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In vivo photoacoustic guidance of stem cell injection and delivery for regenerative spinal cord therapies

Kubelick

Emelianov

2020

Neurophoton.

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Significance: Stem cell therapies are of interest for treating a variety of neurodegenerative diseases and injuries of the spinal cord. However, the lack of techniques for longitudinal monitoring of stem cell therapy progression is inhibiting clinical translation. Aim: The goal of this study is to demonstrate an intraoperative imaging approach to guide stem cell injection to the spinal cord in vivo. Results may ultimately support the development of an imaging tool that spans intra-or postoperative environments to guide therapy throughout treatment. Approach: Stem cells were labeled with Prussian blue nanocubes (PBNCs) to facilitate combined ultrasound and photoacoustic (US/PA) imaging to visualize stem cell injection and delivery to the spinal cord in vivo. US/PA results were confirmed by magnetic resonance imaging (MRI) and histology. Results: Real-time intraoperative US/PA image-guided injection of PBNC-labeled stem cells and three-dimensional volumetric images of injection provided feedback necessary for successful delivery of therapeutics into the spinal cord. Postoperative MRI confirmed delivery of PBNClabeled stem cells. Conclusions: The nanoparticle-augmented US/PA approach successfully detected injection and delivery of stem cells into the spinal cord, confirmed by MRI. Our work demonstrated in vivo feasibility, which is a critical step toward the development of a US/PA/MRI platform to monitor regenerative spinal cord therapies.

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Section: Introductionsupporting

confidence: 53%

Section: Synthesis Of Prussian Blue Nanocubesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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In vivo photoacoustic guidance of stem cell injection and delivery for regenerative spinal cord therapies

Kubelick

Emelianov

2020

Neurophoton.

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“…Fu et al have demonstrated the use of PBNPs as a photothermal ablation agent [ 54 ]. Dumani et al have developed a method for size-controlled synthesis of photomagnetic Prussian blue nanocubes (PBNCs) using superparamagnetic iron oxide nanoparticles (SPION) as the precursor [ 55 ]. The PBNCs are reported to have high magnetic saturation and an optical absorption peak at 700 nm.…”

Section: Exogenous Contrast Agentsmentioning

confidence: 99%

“…The PBNCs are reported to have high magnetic saturation and an optical absorption peak at 700 nm. With superior photostability, PBNCs have been used as contrast agents for both MRI and PAT in vivo [ 55 ].…”

Section: Exogenous Contrast Agentsmentioning

confidence: 99%

A Review of Endogenous and Exogenous Contrast Agents Used in Photoacoustic Tomography with Different Sensing Configurations

Tsang

Wong

2020

Sensors

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Optical-based sensing approaches have long been an indispensable way to detect molecules in biological tissues for various biomedical research and applications. The advancement in optical microscopy is one of the main drivers for discoveries and innovations in both life science and biomedical imaging. However, the shallow imaging depth due to the use of ballistic photons fundamentally limits optical imaging approaches’ translational potential to a clinical setting. Photoacoustic (PA) tomography (PAT) is a rapidly growing hybrid imaging modality that is capable of acoustically detecting optical contrast. PAT uniquely enjoys high-resolution deep-tissue imaging owing to the utilization of diffused photons. The exploration of endogenous contrast agents and the development of exogenous contrast agents further improve the molecular specificity for PAT. PAT’s versatile design and non-invasive nature have proven its great potential as a biomedical imaging tool for a multitude of biomedical applications. In this review, representative endogenous and exogenous PA contrast agents will be introduced alongside common PAT system configurations, including the latest advances of all-optical acoustic sensing techniques.

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Prussian Blue Nanoparticles Stabilize SOD1 from Ubiquitination‐Proteasome Degradation to Rescue Intervertebral Disc Degeneration

et al. 2022

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Discography often destroys the hypoxic environment in the intervertebral disc and accelerates intervertebral disc degeneration (IVDD). Therefore, it often fails to meet the requirements for application in clinical practice. This technology mainly increases the reactive oxygen species (ROS) in the IVD. As so, it is particularly critical to develop strategies to avoid this degeneration mechanism. Prussian blue nanoparticles (PBNPs) are found to enhance development under magnetic resonance T1 and have antioxidant enzyme activity. The key results of the present study confirm that PBNPs alleviate intracellular oxidative stress and increase the intracellular activities of antioxidant enzymes, such as superoxide dismutase 1 (SOD1). PBNPs can rescue nucleus pulposus cell degeneration by increasing oxidoreductase system-related mRNA and proteins, especially by stabilizing SOD1 from ubiquitination-proteasome degradation, thus improving the mitochondrial structure to increase antioxidation ability, and finally rescuing ROS-induced IVDD in a rat model. Therefore, it is considered that PBNPs can be a potential antioxidation-protective discography contrast agent.

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Photomagnetic Prussian blue nanocubes: Synthesis, characterization, and biomedical applications

Cited by 16 publications

References 61 publications

In vivo photoacoustic guidance of stem cell injection and delivery for regenerative spinal cord therapies

In vivo photoacoustic guidance of stem cell injection and delivery for regenerative spinal cord therapies

A Review of Endogenous and Exogenous Contrast Agents Used in Photoacoustic Tomography with Different Sensing Configurations

Prussian Blue Nanoparticles Stabilize SOD1 from Ubiquitination‐Proteasome Degradation to Rescue Intervertebral Disc Degeneration

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