A Review of Endogenous and Exogenous Contrast Agents Used in Photoacoustic Tomography with Different Sensing Configurations

Tsang, Victor T. C.; Li, Xiufeng; Wong, Terence T. W.

doi:10.3390/s20195595

Cited by 40 publications

(60 citation statements)

References 155 publications

(219 reference statements)

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“…PAI has numerous advantages including a high spatial resolution, strong contrast, noninvasiveness, real-time imaging, low cost, and the ability for both endogenous and exogenous imaging, which has attracted wide attention for applications involving the imaging of biological tissues [44]. However, the low laser absorption of the endogenous chromophore leads to a weak signal, which is a major obstacle for deep tissue imaging [81]. Choosing a good NIR-absorbing photoacoustic imaging contrast agent (PAICA) is a necessary condition to ensure the high-quality imaging of biological tissues.…”

Section: Photoacoustic Imagingmentioning

confidence: 99%

The Application of Prussian Blue Nanoparticles in Tumor Diagnosis and Treatment

Gao

Wang

Cheng

et al. 2020

Sensors

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Prussian blue nanoparticles (PBNPs) have attracted increasing research interest in immunosensors, bioimaging, drug delivery, and application as therapeutic agents due to their large internal pore volume, tunable size, easy synthesis and surface modification, good thermal stability, and favorable biocompatibility. This review first outlines the effect of tumor markers using PBNPs-based immunosensors which have a sandwich-type architecture and competitive-type structure. Metal ion doped PBNPs which were used as T1-weight magnetic resonance and photoacoustic imaging agents to improve image quality and surface modified PBNPs which were used as drug carriers to decrease side effects via passive or active targeting to tumor sites are also summarized. Moreover, the PBNPs with high photothermal efficiency and excellent catalase-like activity were promising for photothermal therapy and O2 self-supplied photodynamic therapy of tumors. Hence, PBNPs-based multimodal imaging-guided combinational tumor therapies (such as chemo, photothermal, and photodynamic therapies) were finally reviewed. This review aims to inspire broad interest in the rational design and application of PBNPs for detecting and treating tumors in clinical research.

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Section: Photoacoustic Imagingmentioning

confidence: 99%

The Application of Prussian Blue Nanoparticles in Tumor Diagnosis and Treatment

Gao

Wang

Cheng

et al. 2020

Sensors

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“…4). To promote the LD-based PAM system with more applications, a ring-shaped ultrasonic transducer [17] or other optically transparent ultrasonic transducers [18] can be used to develop a reflection-mode LD-based PAM system. Third, the size of the pulse driver can be further minimized to make the system more compact.…”

Section: Discussionmentioning

confidence: 99%

High-speed high-resolution laser diode-based photoacoustic microscopy for in vivo microvasculature imaging

Li¹,

Tsang²,

Kang³

et al. 2021

Vis. Comput. Ind. Biomed. Art

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Laser diodes (LDs) have been considered as cost-effective and compact excitation sources to overcome the requirement of costly and bulky pulsed laser sources that are commonly used in photoacoustic microscopy (PAM). However, the spatial resolution and/or imaging speed of previously reported LD-based PAM systems have not been optimized simultaneously. In this paper, we developed a high-speed and high-resolution LD-based PAM system using a continuous wave LD, operating at a pulsed mode, with a repetition rate of 30 kHz, as an excitation source. A hybrid scanning mechanism that synchronizes a one-dimensional galvanometer mirror and a two-dimensional motorized stage is applied to achieve a fast imaging capability without signal averaging due to the high signal-to-noise ratio. By optimizing the optical system, a high lateral resolution of 4.8 μm has been achieved. In vivo microvasculature imaging of a mouse ear has been demonstrated to show the high performance of our LD-based PAM system.

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“… 120 Contrast agents are sometimes used to enhance molecular specificity. 148 , 149 To date, only one oncolytic virus has been used for PAI, the previously described vaccinia virus expressing Tyr and Tyrp1, which facilitates melanin production ( Figure 4 D). 112 , 113 Melanin is an ideal contrast agent for PAI, as well as MRI, and overexpression in tumors permitted PAI in an animal model.…”

Section: Optical Imagingmentioning

confidence: 99%

A brief review of reporter gene imaging in oncolytic virotherapy and gene therapy

Concilio

Russell

Peng

2021

Molecular Therapy - Oncolytics

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Reporter gene imaging (RGI) can accelerate development timelines for gene and viral therapies by facilitating rapid and noninvasive in vivo studies to determine the biodistribution, magnitude, and durability of viral gene expression and/or virus infection. Functional molecular imaging systems used for this purpose can be divided broadly into deep-tissue and optical modalities. Deep-tissue modalities, which can be used in animals of any size as well as in human subjects, encompass single photon emission computed tomography (SPECT), positron emission tomography (PET), and functional/molecular magnetic resonance imaging (f/mMRI). Optical modalities encompass fluorescence, bioluminescence, Cerenkov luminescence, and photoacoustic imaging and are suitable only for small animal imaging. Here we discuss the mechanisms of action and relative merits of currently available reporter gene systems, highlighting the strengths and weaknesses of deep tissue versus optical imaging systems and the hardware/reagents that are used for data capture and processing. In light of recent technological advances, falling costs of imaging instruments, better availability of novel radioactive and optical tracers, and a growing realization that RGI can give invaluable insights across the entire in vivo translational spectrum, the approach is becoming increasingly essential to facilitate the competitive development of new virus- and gene-based drugs.

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A Review of Endogenous and Exogenous Contrast Agents Used in Photoacoustic Tomography with Different Sensing Configurations

Cited by 40 publications

References 155 publications

The Application of Prussian Blue Nanoparticles in Tumor Diagnosis and Treatment

The Application of Prussian Blue Nanoparticles in Tumor Diagnosis and Treatment

High-speed high-resolution laser diode-based photoacoustic microscopy for in vivo microvasculature imaging

A brief review of reporter gene imaging in oncolytic virotherapy and gene therapy

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