Peranan Badan Pengawas Obat Dan Makanan Dalam Memberikan Perlindungan Studi Di Kantor Cabang Badan Pengawas Obat Dan Makanan Badan Pengawas Obat Makanan (BPOM) Tanjungbalai

Panjaitan, Bahmid; Martua, Junindra; Arbiah, Arbiah

doi:10.30596/dll.v5i2.3577

Cited by 10 publications

(1 citation statement)

References 2 publications

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“…It can be seen in the data obtained that no more than two tablets deviated more than 5%, and no one tablet deviated more than 10%. The uniformity of tablet weight was influenced by the granules' flow properties and the granules' compressibility [20].…”

Section: Weight Uniformitymentioning

confidence: 99%

The Possible Antidiabetic Effect of Ficus carica L. Tablet on lloxan-Induced Diabetes Model in Rats

Kurniawan

Yusuf

2021

Open Access Maced J Med Sci

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BACKGROUND: Fig leaves are reported to have an effect on reducing blood glucose levels. However, the use of fresh leaves makes the effects obtained is not measurable and efficient. AIM: The purpose of this research was to determine the antidiabetic potential of ethanol extract of fig leaves and to optimize tablet dosage formulations. METHODS: Four tablet formulas were made using the wet granulation method. Formula I (FI), Formula I (FII), and Formula III (FIII) groups to give a tablet of ethanol extract of fig leaves with a dose of 40 mg, 60 mg, and 80 mg and placebo treatment group. There were eight groups of male rats strain Wistar treated as follows: Normal control, negative control, positive control (metformin tablets), basis group, placebo treatment group, F1, F2, and F3 groups. The antidiabetic activity was evaluated from a decrease in rat blood glucose levels. Previously, rats were induced first using alloxan 150 mg/kg intraperitoneally to damage β-pancreatic cells so that the rats could experience increased blood glucose levels. After giving treatment to each group for 14 days, a rat blood sample was then taken on days 9 and 14, which were then analyzed by the GOD PAP method with readings carried out using a spectrophotometer with a wavelength of 500 nm. RESULTS: The average weight (mg) of FI tablets (617.8 ± 3.21%), FII (629.35 ± 8.16%), and FIII (643.6 ± 6.21%), and placebo tablet (666.45 ± 4.36%). As for the uniformity of size, all formulas have a diameter of 0.9 ± 0.0 (cm). For the hardness values of FI (5.7 kg), FII (1.31 kg), and FIII (3.09 kg), placebo tablet (2.98%). The value of friability FI (1.42%), FII (11.8%), and FIII (0.84%), placebo tablet (1.16%). While the disintegration time of FI (11.02 min), FII (10.10 min), and FIII (17.00 min), placebo tablet (12.23%). As for the uniformity of size, all formulas have a diameter of 0.9 ± 0.0 (cm). Whereas the dissolution rate (DE45) of each formulation decreased with increasing dose of extract, FI (73.73%), FII (74.80%), and FIII (69.80%). The treatment group of the ethanol extract of fig leaves at a dose of 40 mg, ethanol extract of fig leaves at a dose of 60 mg, and ethanol extract of fig leaves at a dose of 80 mg could reduce rats’ blood glucose levels with statistically significant results (p < 0.05) compared to negative group. When it was compared to the positive group, it had significant results with a statistical value (p < 0.05). CONCLUSION: Ethanol extract of fig leaf tablets had a significant effect on lowering rats’ blood glucose levels.

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Section: Weight Uniformitymentioning

confidence: 99%

The Possible Antidiabetic Effect of Ficus carica L. Tablet on lloxan-Induced Diabetes Model in Rats

Kurniawan

Yusuf

2021

Open Access Maced J Med Sci

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Preoperative Patient Anxiety Level Before And After Informed Consent For General Anesthesia

Pramono

Raharjo

2021

Russ Open Med J

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Background — Informed consent anesthesia should be administered even in pediatric patients through their parents, thereby reducing anxiety. Objective — This study aimed to determine the difference in anxiety level of the preoperative patient before and after given informed consent about general anesthesia. Settings and Design — This was a quasi-experimental study with one group pre-test and post-test study design. Material and Methods - Patients who were to undergo surgery with general anesthesia in PKU Muhammadiyah Gamping Hospital were the subjects in this study. There were 41 subjects selected as study samples using consecutive sampling. Anxiety level was assessed by the HRS-A scale (0.91 and 0.97). Statistical analysis used: All data were analyzed by the marginal homogeneity comparative test. Results — A significant decrease in preoperative patient anxiety levels was observed after the patient was given general anesthesia informed consent (p<0.05), compared to levels before informed consent. Thus, giving informed consent before general anesthesia could decrease the subject’s anxiety level in preoperative patients. Conclusion — Thus, giving informed consent prior to general anesthesia could decrease the subject’s anxiety level in preoperative patients.

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Governance and regulation of local working requirement and importation: Pharmaceutical industry study

Roisah

Rahayu

Darminto

et al. 2022

JGR

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This paper aims to analyze the governance and regulation of local working requirement (LWR) and importation of pharmaceutical products in Indonesia. Based on the theoretical perspectives of Cottier and Panizzon (2004) and Champ and Attaran (2002), this study aims to analyze the important role of patents through LWR and importation, both directly or indirectly to facilitate the transfer of technology and to stimulate technology transfer with the availability of technology information through patent documents. The research was conducted by using a qualitative descriptive-analytical method. A doctrinal approach was used in this study in the context of reviewing the laws and regulations in the field of patents, the World Trade Organization (WTO) Agreement on Trade-Related Aspects of Intellectual Property Rights (hereinafter TRIPS Agreement), health law, and its derivative regulations. The theory used in this study is about the politics of patent law which focuses on the national interest to pursue local production of patented inventions. The results showed that LWR, pharmaceutical importations provisions, and intellectual property rights law policies as a whole in Indonesia need to be harmonized and integrated with policies on technology transfer, industrial development, trade, and investment. The results underscore the main way in which LWR can contribute directly to the transfer of technology in developing countries.

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Peranan Badan Pengawas Obat Dan Makanan Dalam Memberikan Perlindungan Studi Di Kantor Cabang Badan Pengawas Obat Dan Makanan Badan Pengawas Obat Makanan (BPOM) Tanjungbalai

Cited by 10 publications

References 2 publications

The Possible Antidiabetic Effect of Ficus carica L. Tablet on lloxan-Induced Diabetes Model in Rats

The Possible Antidiabetic Effect of Ficus carica L. Tablet on lloxan-Induced Diabetes Model in Rats

Preoperative Patient Anxiety Level Before And After Informed Consent For General Anesthesia

Governance and regulation of local working requirement and importation: Pharmaceutical industry study

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