Synthesis of curcumin derivate is commonly conducted using conventional heating like heating mantel. The synthesis was usually done in the very long time. An experiment on finding an efficient synthesis method may be necessary to conduct, such as using microwave to replace the energy source. The synthesis of curcumin derivate 1,5-bis(4’-hydroxy-3’-metoxyphenyl)-1,4-pentadiene-3-one or gamavuton-0 assisted by microwave irradiation has been carried out. This synthesis was done on propose of cancer drug discovery to answer the search of new cancer drug on the increase of cancer incidence recently. The synthesis was done under microwave irradiation using vanillin and acetone as the starting material, and hydrochloric acid as the catalyst. Based on the experimental data, the microwave irradiation significantly reduces the reaction time. By using microwave irradiation, the synthesis can be done in a short time.
Objective: The aim of this study was to develop a more effective and environmentally friendly synthesis method for anti-cancer curcumine derivatives, namely 1,5-bis (4’-hydroxy-3’-metoxyfenyl)-1,4-pentadiene-3-one or gamavuton-0.
Methods: The experiment was conducted using two different energy sources, i.e. conventional heating and microwave irradiation. Vanillin and acetone were used as starting materials, and hydrochloric acid as the catalyst. During synthesis, variations in the synthesis period were carried out to study the effect of time on the gamavuton-0 produced. Based on experimental data, energy consumption between conventional method and microwave were evaluated.
Results: Evaluation of energy consumption was calculated based on experimental data. It was found that energy consumption for production using microwave irradiation was reduced to 0.0014 kWh/gram of crude gamavuton-0 products from 0.19 KWh/gram of crude gamavuton-0 product using conventional heating.
Conclusion: Based on calculations from experimental data, microwave irradiation during the synthesis of gamavuton-0 significantly saves energy consumption for synthesis.
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