PENGARUH METODE EKSTRAKSI TERHADAP KADAR FENOLAT TOTAL DAN AKTIVITAS ANTIOKSIDAN DAUN SALAM (Syzygium polyanthum (Wight) Walp.)

Verawati, Verawati; Nofiandi, Dedi; Petmawati, Petmawati

doi:10.22216/jk.v2i2.1744

Cited by 12 publications

(10 citation statements)

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“…However, the results of this study are inversely related to the research of conducted by Verawati et al [29] and Wathan et al [30]. In this study, hot extraction such as soxhletation and reflux showed better antioxidant activity than cold extraction.…”

Section: Antioxidant Activity Of E Longifolia Roots Extractmentioning

confidence: 43%

“…The best antioxidant activity was found in cold extraction methods such as maceration and percolation [29][30]. Phenolic compounds such as flavonoids, that believed to have antioxidant properties and are able to prevent reactive free radicals from damaging cells and their cellular components, is stable to heating with a certain temperature.…”

Section: Antioxidant Activity Of E Longifolia Roots Extractmentioning

confidence: 99%

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Extraction methods effect on antioxidant activity of ethanol extract of ‘pasak bumi’ (Eurycoma longifolia Jack.) root

Anwar

Lutpi

Melinda

et al. 2022

IOP Conf. Ser.: Earth Environ. Sci.

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Pasak bumi (Eurycoma longifolia Jack.) has various benefits, such as the root of E. longifolia is often used as an anti-microbial, anti-malarial, anti-inflammatory, dysentery and aphrodisiac. The antioxidant activity is closely related to the ability of E. longifolia root to maintain a fit condition. The benefits of the medicinal plants can be felt by the general public after going through both traditional and modern processing processes. One of the modern processing methods is to isolate secondary metabolites in plants or known as extraction. This study aims to determine the antioxidant activity of the roots of extracted E. longifolia using 96% ethanol solvent with different extraction methods. Extraction was performed by maceration, percolation, reflux, and soxhletation methods. The antioxidant activity test was carried out using the DPPH(1,1-diphenyl-2-picrylhydrazyl) method. The results shows that the antioxidant activity of E. longifolia extract using various extraction methods in the order soxhletation > reflux > percolation > maceration. From this research, it can be concluded that the percolation can be developed as extraction method of E. longifolia roots.

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Section: Antioxidant Activity Of E Longifolia Roots Extractmentioning

confidence: 43%

Section: Antioxidant Activity Of E Longifolia Roots Extractmentioning

confidence: 99%

Extraction methods effect on antioxidant activity of ethanol extract of ‘pasak bumi’ (Eurycoma longifolia Jack.) root

Anwar

Lutpi

Melinda

et al. 2022

IOP Conf. Ser.: Earth Environ. Sci.

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“…Namun, produk tabir surya yang beredar di pasaran sebagian besar mengandung bahan aktif senyawa sintetik yang memiliki efek samping bagi penggunanya.5Bahkan pada tahun 1994 telah dilakukan penelitian oleh Collins dan Ferguson dimanaterjadi Photoallergic Contact Dermatitis (PCD) pada penggunaan Oksibenzon.6Oleh karena itu, pengembangan tabir surya saat ini lebih mengarah pada pemanfaatan bahan-bahan alam dengan alasan bahan alam lebih murah, mudah didapatkan serta diyakini tidak memiliki efek samping yang berbahaya bila dibandingkan dengan bahan-bahan kimia sintetis. 7 Salah satu tanaman yang berpotensi sebagai tabir surya yaitu daun salam (Syzygium polyanthum (Wight) Walp.). Potensi daun salam sebagai tabir surya didukung oleh hasil penelitian Verawati dkk (2017) yang melaporkan ekstrak etanol 70% daun salam memiliki aktivitas antioksidan kategori sangat kuat dengan nilai IC50 35,057µg/mL.8Pemberian antioksidan pada kulit dapat mencegah proses kerusakan kolagen oleh ROS (Reactive Oxygen Species) yang terbentuk selama paparan sinar UV.9 Secara tradisional, daun salam digunakan untuk mengobati kolesterol tinggi, kencing manis, hipertensi, gastritis, dan diare.10 Kandungan senyawa metabolit sekunder dalam ekstrak daun salam yaitu fenolik, flavonoid, steroid, saponin, triterpenoid, alkaloid dan tanin.11 Fenolik dan flavonoid merupakan senyawa utama yang memiliki potensi sebagai tabir surya, karena senyawa tersebut mempunyai gugus kromofor yang dapat menyerap sinar UV.…”

Section: Pendahuluanunclassified

Formulasi Sediaan Lotion Ekstrak Etanol Daun Salam (Syzygium polyanthum (Wight) Walp.) dan Penentuan Nilai SPF Secara in Vitro

Utami¹

2021

PJI

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Sinar Ultraviolet (UV) merupakan sebagian kecil dari spektrum sinar matahari yang sampai ke permukaan bumi dan paling berbahaya bagi kulit sehingga dibutuhkan tabir surya untuk mencegah gangguan akibat sinar UV tersebut. Daun salam mengandung senyawa fenolik, flavonoid, dan tanin yang berpotensi sebagai tabir surya. Tujuan dari penelitian ini yaitu untuk menentukan formula, karakteristik fisik, dan nilai SPF dari lotion ekstrak etanol daun salam (Syzygium polyanthum (Wight) Walp.). Pada penelitian ini, daun salam diekstraksi dengan metode sonikasi menggunakan pelarut etanol 96%. Ekstrak tersebut diformulasikan dalam bentuk sediaan lotion kemudian dilakukan evaluasi sifat fisik. Selanjutnya dilakukan penentuan nilai SPF pada ekstrak dan sediaan lotion yang mengacu pada persamaan Mansur menggunakan instrumen spektrofotometer UV-Vis. Konsentrasi ekstrak daun salam yang digunakan pada formula sediaan lotion yaitu 0,1% (F1) dan 0,5% (F2). Hasil sifat fisik dari sediaan yaitu berwarna krem (F1) dan berwarna hijau kecoklatan (F2), aroma khas ekstrak daun salam, bertekstur lembut dan homogen, memiliki tipe emulsi M/A, daya sebar 5,92 cm (F1) dan 6,05 cm (F2), daya lekat 0,86 detik (F1) dan 0,78 detik (F2), pH 7,82 (F1) dan 7,74 (F2), serta nilai akseptabilitas yang sangat baik. Berdasarkan hasil uji sifat fisik tersebut, lotion ekstrak daun salam memenuhi syarat pada uji homogenitas, daya sebar, dan pH, serta tidak memenuhi syarat pada uji daya lekat. Nilai SPF sediaan lotion ekstrak daun salam yaitu 4,97 (F1) dan 6,72 (F2) dengan tipe proteksi sedang dan ekstra. Semakin tinggi nilai SPF maka semakin tinggi tingkat proteksi terhadap sinar UV sehingga lotion F2 lebih baik dibandingkan F1.

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“…A number of studies have shown that the content of secondary metabolites that are antioxidants in it such as phenolics, alkaloids, saponins, steroids, terpenoid tannins in bay leaves are able to detoxify the body, so it has the potential to treat acid disease. uric acid, lowers cholesterol levels, lowers high blood pressure (Verawati et al, 2017), acetylcholinesterase inhibitory, prevention of plaque on teeth (Ismail and Ahmad, 2019), Flavonoids provide antioxidant effects that are very beneficial to prevent cancer and provide some protection for diabetes and atherosclerosis. (Sani et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective Effectiveness Test of Salam Leaf Extract in Anthracyclin-Induced Rats

Halim

Girsang

Nasution

2022

IJHP

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Cancer is the most often diagnosed disease in the world and the top cause of death. Doxorubicin is a widely used systemic therapy, although its efficacy is limited by dose-related toxicity, including haematological suppression, organotoxicity, and hepatotoxicity. Bay leaf is a commonly utilised plant in the community for treating and preventing many diseases because it includes secondary metabolites that are antioxidants such as phenolics, alkaloids, saponins, steroids, triterpenoids, and tannins. The purpose of this work is to characterise EEDS, identify its secondary metabolite content, and test its nephroprotective effect in doxorubicin-induced rats using SGPT and SGOT levels and liver histology. This is a laboratory experimental investigation using rats and comprises of treatment groups receiving 0.5% of CMC-Na, Nature E, or EEDS at doses of 100 mg/kgBW, 300 mg/kgBW, or 500 mg/kgBW, respectively, followed by doxorubicin. The results indicated that EEDS had 21.64 % water soluble material, 1.79 % total ash, 9.98 % water, 45.38 % ethanol soluble extract, and 0.39 % acid insoluble ash. EEDS included alkaloids, flavonoids, tannins, glycosides, saponins, and steroids/triterpenoids, as determined by phytochemical screening. EEDS doses of 100 mg/kgBW, 300 mg/kgBW, and 500 mg/kgBW can significantly lower SGPT by 34%; 52,46%; 59,31% and SGOT levels by 27,05%; 43,96%; 50,07% and can improve the liver histopathology of doxorubicin-induced rats by reducing pyknotic degeneration, inflammatory cell infiltration, bleeding, steatosis and sinusoidal dilatation with an effective dose of 500 mg/kgBW with a significant difference with the doxorubicin group followed by 0.5% CMC Na. The key to bay leaf ethanol extract has hepatoprotective activity.

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PENGARUH METODE EKSTRAKSI TERHADAP KADAR FENOLAT TOTAL DAN AKTIVITAS ANTIOKSIDAN DAUN SALAM (Syzygium polyanthum (Wight) Walp.)

Cited by 12 publications

References 1 publication

Extraction methods effect on antioxidant activity of ethanol extract of ‘pasak bumi’ (Eurycoma longifolia Jack.) root

Extraction methods effect on antioxidant activity of ethanol extract of ‘pasak bumi’ (Eurycoma longifolia Jack.) root

Formulasi Sediaan Lotion Ekstrak Etanol Daun Salam (Syzygium polyanthum (Wight) Walp.) dan Penentuan Nilai SPF Secara in Vitro

Hepatoprotective Effectiveness Test of Salam Leaf Extract in Anthracyclin-Induced Rats

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