Ovine and caprine cutaneous and ocular neoplasms

Aljawadi, Ahmed; Hassanein, Khaled

doi:10.1016/j.smallrumres.2012.03.007

Cited by 32 publications

(43 citation statements)

References 31 publications

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“…is result investigated the function of papillomavirus in the development of tumor in small ruminant as described previously in bovine and humans [3,37]. ese results are compatible with the previous findings of another study on ovine and caprine papillomavirus reported elsewhere in the world [36][37][38][39][40]. Papillomaviruses have approved their essential contribution to the development of human and animal cancers such as skin cancer [1,3,41,42].…”

Section: Discussionsupporting

confidence: 89%

Clinico-Histopathological and Immunohistochemical Study of Ruminant’s Cutaneous Papillomavirus in Iraq

Al-Salihi

Al-Dabhawi

Ajeel

et al. 2020

Veterinary Medicine International

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e papilloma viruses are constituted of double-stranded DNA and are a more common lesion in ruminant's skin in Iraq. e p53 tumor suppressor protein reveals an essential role in cell cycle control. is study intends to investigate the clinical, histopathological, and immunohistochemical features of cutaneous papilloma in ruminants in Iraq. Samples had been collected from a total of 10 animals (three cattle, three goats, and four sheep) with multiple papillomatosis lesions. e samples were processed for histopathological and immunohistochemical techniques. Clinically, the lesions appeared as multiple various sizes (0.5-11 cm), cauliflower exophytic masses on different parts of the animal's body. e histopathological features of the epidermis granular layer revealed perinuclear vacuolation (koilocytosis) accompanied by various degrees of hypergranulosis, hyperkeratosis, acanthosis, orthokeratosis, and parakeratosis. Strong positive reaction for papillomavirus antigen was seen in both epidermal basal and granular layers in the immunohistochemical investigation (IHC). Moreover, all papilloma lesions revealed an intense positive p53 reaction in cytoplasmic and perinuclear of the basal and parabasal layers. In conclusion, this study described the papillomavirus lesions in bovine, ovine, and caprine animals, which were found in different parts areas of the affected animals. All lesions show similar histopathological features with minor variations. PV antigen and p53 protein expression showed positive results in immunohistochemistry that can be used as diagnostic markers for ruminant's papilloma.

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Section: Discussionsupporting

confidence: 89%

Clinico-Histopathological and Immunohistochemical Study of Ruminant’s Cutaneous Papillomavirus in Iraq

Al-Salihi

Al-Dabhawi

Ajeel

et al. 2020

Veterinary Medicine International

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“…Ovine neoplasms are uncommon in general. SCC is the most common ocular and periocular neoplasm in sheep, but it tends to occur in this location only in animals that have non-pigmented skin or white colored head (Ahmed & Hassanein 2012). Other periocular tumors that have been reported in sheep are Meibomian gland adenoma (Rezaie et al 2012), and basal cell tumor (Gorham et al 1990).…”

Section: Discussionmentioning

confidence: 99%

Fifty years in the blink of an eye: a retrospective study of ocular and periocular lesions in domestic animals

Martins

Barros

2014

Pesq. Vet. Bras.

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Pesq. Vet. Bras. 34(12):1215-1222, dezembro 2014 1215 RESUMO.-[Cinquenta anos num piscar de olhos: um estudo retrospectivo sobre lesões oculares e perioculares em animais domésticos.] Foi realizada uma investigação para obter-se uma visão geral das lesões oculares e perioculares de mamíferos domésticos diagnosticadas ao longo de um período de 50 anos num laboratório de diagnóstico de patologia veterinária da Região Central do Rio Grande do Sul. Nesse laboratório, durante o período pesquisado foram realizados 33.075 exames histopatológicos, 540 dos quais (1,6%) eram de lesões oculares e perioculares. Por várias razões, 90 espécimes foram excluídos do estudo. As 450 amostras restantes consistiam espécimes de cães (53,5%), bovinos (28,2%), gatos (11,1%), cavalos (5,1%), ovelhas (1,3%), coelhos (0,4%), e porco (0,2% A survey was undertaken aiming to obtain an overview of ocular and periocular lesions diagnosed in domestic mammals over a period of 50 years in a veterinary pathology diagnostic laboratory in the Central Region of the State of Rio Grande do Sul, Brazil. In this lab, 33,075 histophatological exams had been performed over the period surveyed, of which 540 (1.6%) concerned ocular and periocular lesions. For various reasons ninety specimens were excluded from the study and the remaining 450 consisted of samples from dogs (53.5%), cattle (28.2%), cats (11.1%), horses (5.1%) sheep (1.3%), rabbits (0.4%), and pig (0.2%). The eyelids were the most prevalent (248/450) site of lesions in each of the species studied, followed by third eyelid (73/450), and conjunctiva (27/450). In dogs (241 samples) lesions in sebaceous glands (including Meibomian glands) were the most common findings (75/241), followed by melanocytic tumors (52/241) and nonspecific conjunctivitis (13/241). Squamous cell neoplasms, both benign and malignant, were relatively common. In cattle, anatomical sites affected by ocular and periocular lesions, in decreasing order of frequency, were eyelid, cornea and third eyelid. Squamous cell carcinoma (SCC) alone accounted for 80.3% of all diagnoses, while all neoplastic lesions made up for 85.0% of the lesions diagnosed in cattle. Neoplasia accounted for most of the lesions diagnosed in cats (39/50 cases); all of these were malignant, and SCC, hemangiosarcoma and fibrosarcoma were the most common types diagnosed. In horses, 19 out of 23 submissions were neoplasms and most were sarcoid (8/23) and SCC (8/23). There were six submissions from sheep with unpigmented skin, all of which represented SCC of the eyelids (5) and third eyelid (1).

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“…Melanocytic tumours are rare in small ruminant with the exception of Angora breed goats (Ramadan et al, 1988;Ahmed and Hassanein, 2012). Melanomas in this species are highly malignant.…”

Section: Discussionmentioning

confidence: 99%

“…In these animal species it is possible that the presence of single or multiple lesions are present within the epidermis, at the epidermal-dermal junction, ଝ This paper is part of a supplement issue entitled "S.I.P. A or in the dermal/subcutaneous tissue in the areas where the skin is thinner and with sparse hair, like ears, mouth, base of the horns, perineal region, udder, the coronary band (Sockett et al, 1984;Ramadan et al, 1988;Derakhshanfar et al, 2007;Mavangira et al, 2008;Hansmann et al, 2010;Ahmed and Hassanein, 2012;Ozyildiz et al, 2012;Fazili et al, 2013) and the eye (Omar and Collins, 1961;Ortín et al, 2006;Canpolat et al, 2007;Ahmed and Hassanein, 2012). The researchers describe the macroscopic and histological findings of three cases of melanoma in small ruminants from three different farms of Sicily.…”

Section: Introductionmentioning

confidence: 99%

Three cases of melanoma in small ruminants: Clinical symptoms and pathological results

Mignacca

Capucchio

Biasibetti

et al. 2015

Small Ruminant Research

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Ovine and caprine cutaneous and ocular neoplasms

Cited by 32 publications

References 31 publications

Clinico-Histopathological and Immunohistochemical Study of Ruminant’s Cutaneous Papillomavirus in Iraq

Clinico-Histopathological and Immunohistochemical Study of Ruminant’s Cutaneous Papillomavirus in Iraq

Fifty years in the blink of an eye: a retrospective study of ocular and periocular lesions in domestic animals

Three cases of melanoma in small ruminants: Clinical symptoms and pathological results

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