Three cases of melanoma in small ruminants: Clinical symptoms and pathological results

Mignacca, S.A.; Capucchio, M.T.; Biasibetti, Elena; Guarneri, Giovanni; Milone, Sergio; Marchisotta, A.; Amato, Benedetta; Presti, Vincenzo Di Marco Lo

doi:10.1016/j.smallrumres.2015.01.016

Cited by 3 publications

(2 citation statements)

References 12 publications

(21 reference statements)

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“…Although melanocytic cutaneous neoplasms in small ruminants are rare, it is suggested that Angora is susceptible to melanoma [ 35 ]. Of the studies reviewed, most were case reports and/or retrospective studies associated with other species [ 13 , 34 , 36 , 37 ]. Another aspect that draws attention is that most melanocytic lesions and/or neoplasms can metastasize to other organs such as the liver, lung, kidney, sternum, and mandible [ 38 , 39 ].…”

Section: Discussionmentioning

confidence: 99%

Neoplasms in Domestic Ruminants and Swine: A Systematic Literature Review

Vasconcelos

Pires

Alves

et al. 2023

Veterinary Sciences

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Background: Due to the limited information and lack of studies on neoplasms in domestic ruminants, i.e., cattle, sheep, and goats, and domestic swine, the objective of the present study was to systematically review the scientific literature to verify the occurrence, type, organ system, and organs most affected by neoplasms in these animals. Methods: The recommendations of the PRISMA methodology were followed for the elaboration of this study. The research consisted of a systematic review of neoplasms in domestic cattle, sheep, goats, and swine. Results: The number of neoplasms found was 1873. The most affected organ system was the integumentary system with 35.0%, followed in descending order by the alimentary system with 16.90%, the hematopoietic system with 13.50%, the special senses (i.e., eyes and ears) with 10.51%, the female and male genital systems with 7.31%, the urinary system with 4.38%, the liver and biliary system with 3.152%, the endocrine glands with 3.91%, the respiratory system with 2.67%, the nervous system with 2.35%, bones and joints with 0.43%, muscles and tendons with 0.37%, the cardiovascular system with 0.21%, and the pancreas with 0.16%. Of the animals with neoplasms studied, cattle were affected in 69.80% of cases, goats in 10.52%, sheep in 10.46%, and swine in 9.18%. In all species, the most frequent neoplasms were squamous cell carcinomas in ruminants, while melanoma was the most frequent in swine. Few studies carried out in slaughterhouses were found, and the existing ones referred to cattle and swine. No data were found on economic losses with carcass condemnation. Conclusions: In view of the above, it is necessary to carry out extensive and detailed studies that provide knowledge about the impact of neoplasms on the production and condemnation of carcasses in domestic cattle, sheep, goats, and swine and the respective risk factors.

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Section: Discussionmentioning

confidence: 99%

Neoplasms in Domestic Ruminants and Swine: A Systematic Literature Review

Vasconcelos

Pires

Alves

et al. 2023

Veterinary Sciences

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“…Melanocytic neoplasms have been commonly reported in most species especially dogs, horses and some breeds of swine (4). In sheep and goats, the pigmented melanocytic tumors are quite uncommon (10,12). Although more than 90% of the melanocytic neoplasms usually originate from the skin, these tumors may occur metastatically in other sites without an identified primary lesion (7,8).…”

Section: Introductionmentioning

confidence: 99%

Melanoma of unknown primary origin metastasizing to visceral organs in a sheep

Oryan¹,

Ghane²,

Ahmadi³

et al. 2018

BJVP

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Malignant melanomas are quite uncommon in sheep and goats. A three-year-old native female sheep with a history of sudden death was referred for postmortem examination. Gross evaluations revealed multiple brown to black neoplastic masses with compact nodular appearance, involving lungs, mediastinal lymph nodes, liver and kidneys. Comprehensive physical examination of skin, all mucous membranes and mucocutaneous junctions revealed no evidence of concomitant pigmented lesions or dark discoloration. Microscopically, the masses were predominantly composed of round and polyhedral-shaped neoplastic cells of various sizes with abundant pale eosinophilic cytoplasm containing variable amounts of dark brown melanin pigment and peripherally located, oval to round, vesicular nuclei with prominent nucleoli. Immunohistochemically, the neoplastic cells displayed diffuse and positive expression for S100 protein, vimentin and melan-A. These histopathological and immunohistochemical findings were consistent with a final diagnosis of metastatic malignant melanoma, "epithelioid" type. To the author' knowledge, metastatic melanoma without an identified primary origin has not yet been reported in the domestic animals.

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