2018
DOI: 10.3177/jnsv.64.301
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Orally Administered Polysaccharide Derived from Blackcurrants (<i>Ribes nigrum</i> L.) Improves Skin Hydration in Ultraviolet-Irradiated Hairless Mice

Abstract: Blackcurrants (Ribes nigrum L.) have various benefits for human health. In particular, a polysaccharide derived from blackcurrant was found to be an immunostimulating food ingredient in a mouse model. We named a polysaccharide derived from blackcurrant cassis polysaccharide (CAPS). In a previous clinical study, we reported that CAPS affects skin dehydration, demonstrating its effectiveness against skin inflammation was related to atopic dermatitis; skin inflammation caused skin dehydration. However, there are … Show more

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Cited by 4 publications
(2 citation statements)
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“…The results demonstrated that the polysaccharide was able to counteract skin dehydration induced by UV irradiation; the stratum corneum hydration was significantly higher in both cassis polysaccharide groups (UV-treated groups) than in the UV-treated control group. Compared to the UV control group, IL-6 gene expression level was significantly lower in both cassis polysaccharide groups (UV treated), while the MMP-13 gene expression level was significantly lower only in 1% cassis polysaccharide group [ 63 ].…”
Section: Resultsmentioning
confidence: 99%
“…The results demonstrated that the polysaccharide was able to counteract skin dehydration induced by UV irradiation; the stratum corneum hydration was significantly higher in both cassis polysaccharide groups (UV-treated groups) than in the UV-treated control group. Compared to the UV control group, IL-6 gene expression level was significantly lower in both cassis polysaccharide groups (UV treated), while the MMP-13 gene expression level was significantly lower only in 1% cassis polysaccharide group [ 63 ].…”
Section: Resultsmentioning
confidence: 99%
“…The animal behavior did not change during the research. In these studies, the topical use of some substances (DNCB, DNFB and DEE) (13,15,18,(20)(21)(22)(23)(24)26), some nutrients (cow milk, red Korean ginseng) (16,21), UV radiations (25) and injections with Apigenin (19) could explain the appearance of skin lesions in AD.…”
Section: Discussionmentioning
confidence: 99%