A Review of the Potential Benefits of Plants Producing Berries in Skin Disorders

Abstract

During the last 30 years, berries have gained great attention as functional food against several risk factors in chronic diseases. The number of related publications on Pubmed rose from 1000 items in 1990 to more than 11,000 in 2019. Despite the fact that a common and clear definition of “berries” is not shared among different scientific areas, the phytochemical pattern of these fruits is mainly characterized by anthocyanins, flavanols, flavonols, and tannins, which showed antioxidant and anti-inflammatory properties in humans. Skin insults, like wounds, UV rays, and excessive inflammatory responses, may lead to chronic dermatological disorders, conditions often characterized by long-term treatments. The application of berries for skin protection is sustained by long traditional use, but many observations still require a clear pharmacological validation. This review summarizes the scientific evidence, published on EMBASE, MEDLINE, and Scholar, to identify extraction methods, way of administration, dose, and mechanism of action of berries for potential dermatological treatments. Promising in vitro and in vivo evidence of Punica granatum L. and Vitis vinifera L. supports wound healing and photoprotection, while Schisandra chinensis (Turcz.) Baill. and Vaccinium spp. showed clear immunomodulatory effects. Oral or topical administrations of these berries justify the evaluation of new translational studies to validate their efficacy in humans.

Development and Characterization of Biointeractive Gelatin Wound Dressing Based on Extract of Punica granatum Linn

“…Our results suggest that the GELPG dressing is biocompatible, nontoxic, and that it improves wound healing. Other plant extracts rich in antioxidant compounds, such as gallic and ellagic acids, have also demonstrated to improve wound closure [ 32 , 33 ], but the precise mechanism underpinning the effect of the AEPG on the WCR is not yet clear. The wound closure process is mediated by two major pathophysiological events: wound contraction and epithelization [ 34 ].…”

Determination of Phenolic Content, Antioxidant Activity, and Tyrosinase Inhibitory Effects of Functional Cosmetic Creams Available on the Thailand Market

“…According to the product marketing materials, many plant extracts have been added to the cream formulations, and were previously reported for their high content of phenolic compounds and showed high amount of total phenolic contents in our study; these extracts were included, Vitis vinifera (sample No. 1) [ 13 ], Citrus species (sample No. 2 and No.…”

“…Likewise, consumer demand continues to increase for the innovative uses of natural compounds to treat skin aging manifestations including wrinkles, sagging skin, skin texture changes, and hyperpigmentation [ 7 , 8 , 9 , 10 ]. Accordingly, cosmetic manufacturers have begun offering organic lines of products and natural solutions to treat a variety of problems and diseases associated with the skin including hyperpigmentation, sun burn, skin aging, erythema, rash, and atopic dermatitis [ 3 , 11 , 12 , 13 , 14 ]. In the cosmetic industry, many polyphenols obtained from plants and natural extracts hold promise as they have exhibited a range of beneficial effects on skin in both in vitro and in vivo studies [ 15 , 16 , 17 ].…”

Comparative study of the photo‑protective and anti‑melanogenic properties of gomisin D, J and O

“…In recent years, the use of natural products and bioactive compounds has increased worldwide (29,30). A number of studies have been conducted on the efficacy of bioactive compounds in the development of natural products (31)(32)(33). Brightening candidates from natural products are non-toxic and can be safely used in cosmetic and pharmaceutical formulations to aid in the development of efficient natural brightening agents (6).…”

“…Natural products are of increasing interest due to their potential antioxidant, anti-inflammatory, antitumor and antibacterial activities ( 34 , 35 ). Based on the properties of photoprotection and melanogenesis, several cosmetic and pharmaceutical candidates with antioxidant, photoprotective and anti-melanogenic effects have been investigated ( 31 , 36 , 37 ). Dibenzocyclooctadiene lignans are one of the most widely used biologically active compounds extracted from Kadsura medicinal plants in China and other Asian countries ( 2 , 38 ).…”