Polysaccharides from Annona muricata leaves protect normal human epidermal keratinocytes and mice skin from radiation-induced injuries

Byun, Eui‐Baek; Song, Ha-Yeon; Kim, Woo Sik

doi:10.1016/j.radphyschem.2019.108672

Cited by 20 publications

(14 citation statements)

References 24 publications

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“…According to our results, protein bands detected in ARP had high molecular weights of 129, 109, 96, 87 and 55 kDa that might adversely influence ARP migration through the skin cuticle to enter the dermis. Nevertheless, Byuna et al 44 reported that polysaccharides from Annona muricata leaves protected mice skin from radiation‐induced injuries. Taken together, these results suggest that even large molecules acting via diverse mechanisms may protect skin from radiation‐induced injury, warranting further study.…”

Section: Discussionmentioning

confidence: 99%

Akt activation‐dependent protective effect of wild ginseng adventitious root protein against UVA‐induced NIH‐3T3 cell damage

Sun

Liu

et al. 2021

Wound Repair Regeneration

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Prolonged skin exposure to ultraviolet radiation can lead to development of several acute and chronic diseases, with UVA exposure considered a primary cause of dermal photodamage. We prepared a wild ginseng adventitious root extract (ARE) that could alleviate UVA irradiation-induced NIH-3T3 cell viability decline. After employing a series of purification methods to isolate main active components of ARE, adventitious root protein mixture (ARP) was identified then tested for protective effects against UVA irradiation-induced NIH-3T3 cell damage. The results showed that ARP treatment significantly reduced UVA-induced cell viability decline and confirmed that the active constituent of ARP was the protein, since proteolytic hydrolysis and heat treatment each eliminated ARP protective activity. Moreover, ARP treatment markedly inhibited UVA-induced apoptosis, cell cycle arrest and DNA fragmentation, while also significantly reversing UVA effects (elevated Bax levels, reduced Bcl-2 expression) by reducing Bax levels and increasing Bcl-2 expression. Mechanistically, ARP promoted Akt phosphorylation regardless of UVA exposure, thus confirming ARP resistance to inactivation by UVA light. Notably, in the presence of Akt inhibitor SC0227, ARP could no longer counteract UVA-induced cell viability decline and DNA fragmentation. Additionally, our results demonstrated that ARP treatment protected UVA-irradiated NIH-3T3 cells by preventing UVA-induced reduction of collagen-I expression. Taken together, these results suggest that ARP treatment of NIH-3T3 cells effectively mitigated UVA-induced cell viability decline by activating intracellular Akt to reduce UVA-induced DNA damage, leading to reduced rates of apoptosis and cell cycle arrest after UVA exposure and restoring collagen expression to normal levels.

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Section: Discussionmentioning

confidence: 99%

Akt activation‐dependent protective effect of wild ginseng adventitious root protein against UVA‐induced NIH‐3T3 cell damage

Sun

Liu

et al. 2021

Wound Repair Regeneration

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“…Studies conducted in vitro and in vivo suggest that graviola contains antioxidant compounds that act as free-radical scavengers and increase the activity of the antioxidant enzymes superoxide dismutase and catalase and downregulate the function of mitochondrial NADPH oxidase complex I [199][200][201]. The leaf and the fruit pulp of graviola are the parts of the tree with the highest antioxidant properties [182].…”

Section: Antioxidantmentioning

confidence: 99%

Biomedical Effects of the Phytonutrients Turmeric, Garlic, Cinnamon, Graviola, and Oregano: A Comprehensive Review

et al. 2021

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Phytonutrients are plant foods that contain many natural bioactive compounds, called phytochemicals, which show specific biological activities. These phytonutrients and their phytochemicals may play an important role in health care maintaining normal organism functions (as preventives) and fighting against diseases (as therapeutics). Phytonutrients’ components are the primary metabolites (i.e., proteins, carbohydrates, and lipids) and phytochemicals or secondary metabolites (i.e., phenolics, alkaloids, organosulfides, and terpenes). For years, several phytonutrients and their phytochemicals have demonstrated specific pharmacological and therapeutic effects in human health such as anticancer, antioxidant, antiviral, anti-inflammatory, antibacterial, antifungal, and immune response. This review summarizes the effects of the most studied or the most popular phytonutrients (i.e., turmeric, garlic, cinnamon, graviola, and oregano) and any reported contraindications. This article also presents the calculated physicochemical properties of the main phytochemicals in the selected phytonutrients using Lipinski’s, Veber’s, and Ghose’s rules. Based on our revisions for this article, all these phytonutrients have consistently shown great potential as preventives and therapeutics on many diseases in vitro, in vivo, and clinical studies.

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“…Studies conducted in vitro and in vivo suggest that graviola contains antioxidant compounds that act as free-radical scavengers and increase the activity of the antioxidant enzymes superoxide dismutase and catalase and downregulate the function of mitochondrial NADPH oxidase complex I, [195][196][197]. The leaf and the fruit pulp of graviola are the parts of the tree with the highest antioxidant properties [178].…”

Section: Antioxidantmentioning

confidence: 99%

Biomedical Effects of Popular Phytonutrients and Their Phytochemicals: A Comprehensive Review

Delgado¹,

Cassé²,

Ferrer-Acosta³

et al. 2021

Preprint

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Phytonutrients are plant foods that contain many natural bioactive compounds, called phytochemicals, which expose specific biological activities. These phytonutrients and their phytochemicals may play an important role in health care maintaining normal organism functions (as preventives) and fighting against diseases (as therapeutics). Phytonutrient’s components are the primary metabolites (i.e., proteins, carbohydrates, and lipids) and phytochemicals or secondary metabolites (i.e., phenolics, alkaloids, organosulfides, and terpenes). For years, several phytonutrients and their phytochemicals have demonstrated specific pharmacological and therapeutic effects in human health such as anticancer, antioxidant, antiviral, anti-inflammatory, antibacterial, antifungal, and immune response. This review summarizes the effects of the most studied or the most popular phytonutrients (i.e., turmeric, garlic, cinnamon, graviola, and oregano), and any contraindication found. This article also calculated the physicochemical properties of the main phytochemicals in the selected phytonutrients using Lipinski’s, Veber’s and Ghose’s rules. Based on our revisions for this article, all these phytonutrients have consistently shown several in vitro, in vivo, and clinical studies with great potential as preventives and therapeutics on many diseases.

show abstract

Polysaccharides from Annona muricata leaves protect normal human epidermal keratinocytes and mice skin from radiation-induced injuries

Cited by 20 publications

References 24 publications

Akt activation‐dependent protective effect of wild ginseng adventitious root protein against UVA‐induced NIH‐3T3 cell damage

Akt activation‐dependent protective effect of wild ginseng adventitious root protein against UVA‐induced NIH‐3T3 cell damage

Biomedical Effects of the Phytonutrients Turmeric, Garlic, Cinnamon, Graviola, and Oregano: A Comprehensive Review

Biomedical Effects of Popular Phytonutrients and Their Phytochemicals: A Comprehensive Review

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