Oral submucous fibrosis: A quantitative assessment of serum malondialdehyde, superoxide dismutase and correlation with clinical staging

Bale, Ratnakar; Kattappagari, Kiran Kumar; Vidya, Desai; Vuddandi, Sivapradobh; Gummalla, Charani; Baddam, Venkata Ramana Reddy

doi:10.4103/jomfp.jomfp_214_16

Cited by 9 publications

(5 citation statements)

References 17 publications

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“…Another study with similar results was conducted by Gurudath et al [16], where the mean serum SOD level in OSF group was significantly decreased as compared to the control group. Also, the study conducted by Bale R. et al [17] showed consistent results. Comparison of SOD levels between healthy volunteers and OSMF participants was statistically significant.…”

Section: Resultssupporting

confidence: 58%

Evaluation of Salivary Superoxide Dismutase Levels in Oral Submucous Fibrosis – A Cross Sectional Study

Nagar¹,

Sujatha²,

Lingappa³

2021

EJMED

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Background: Oral Submucous Fibrosis (OSMF) is a potentially malignant disorder with areca nut being the main etiological agent. Increased risk of malignant potential of OSMF necessitates the early diagnosis of the condition. Superoxide dismutase (SOD) scavenges oxygenated free radicals and can be used as a potential biomarker for oral cancer detection. Objectives: The present study was conducted to estimate and compare salivary SOD levels in patients with OSMF and healthy controls and to compare its levels in different clinical and functional stages of OSMF. Methodology: The study group (Group 1) included 30 patients of OSMF, and the control group (Group 2) was formed by age and sex-matched healthy individuals. Salivary SOD levels were determined by Nitro Blue Tetrazolium (NBT) chloride method. The levels of salivary SOD were compared between the two groups and the data thus obtained was subjected to statistical analysis using independent sample t-test and one way Analysis of variance (ANOVA) test. Results: The mean salivary SOD in the study group was 0.583 IU/mL and 0.864 IU/mL in control group and the difference was found to be statistically significant. Thus, the patients with OSMF had significantly lower levels of salivary SOD compared to the controls. Conclusion: The decrease in the salivary SOD levels in patients with OSMF suggests the role of oxidative stress in the pathogenesis of OSMF and initiation and progression of carcinogenesis. Thus, it can be used as a prognostic marker for early detection of carcinoma in patients with OSMF and thereby, improving the quality of life patients.

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Section: Resultssupporting

confidence: 58%

Evaluation of Salivary Superoxide Dismutase Levels in Oral Submucous Fibrosis – A Cross Sectional Study

Nagar¹,

Sujatha²,

Lingappa³

2021

EJMED

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“…Serum samples from OSMF patients revealed increased MDA [24], ceruloplasmin [29], LPOs [8], nitric oxide [30], and decreased levels of beta-carotene, vitamin E [8], and SOD levels [30]. Human studies largely demonstrated elevated levels of oxidative stress biomarkers serum MDA [8,23,25,26,83], salivary 8-hydroxy-2 -deoxyguanosine [31], salivary 8isoprostane [33], salivary lactoperoxidase and total salivary protein [34], and serum copper [27,28], calcium, magnesium, potassium, iron, LPOs, conjugated dienes, and hydroxyl radicals [28]. MDA was found by two articles to be more significant with higher clinical OSMF staging and grading [8,83], while 8-OHdG (salivary oxidative stress biomarker) levels were almost double in OSMF patients [31].…”

Section: Oxidative Stress Biomarkers Is Osmfmentioning

confidence: 99%

“…Human studies largely demonstrated elevated levels of oxidative stress biomarkers serum MDA [8,23,25,26,83], salivary 8-hydroxy-2 -deoxyguanosine [31], salivary 8isoprostane [33], salivary lactoperoxidase and total salivary protein [34], and serum copper [27,28], calcium, magnesium, potassium, iron, LPOs, conjugated dienes, and hydroxyl radicals [28]. MDA was found by two articles to be more significant with higher clinical OSMF staging and grading [8,83], while 8-OHdG (salivary oxidative stress biomarker) levels were almost double in OSMF patients [31]. Interestingly, studies investigating the level of antioxidant enzymes in OSMF have produced conflicting results.…”

Section: Oxidative Stress Biomarkers Is Osmfmentioning

confidence: 99%

A Comprehensive Analysis of the Role of Oxidative Stress in the Pathogenesis and Chemoprevention of Oral Submucous Fibrosis

Saso

Ahmad

et al. 2022

Antioxidants

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Oral submucous fibrosis (OSMF) is a chronic oral potentially malignant disorder (OPMD). It is described as a scarring disease of the oral mucosa associated with excess oxidants and insufficient antioxidants. While it is becoming increasingly accepted that oxidative stress results in excessive accumulation of collagen and progressive fibrosis of the submucosal tissues, there is limited data regarding the moderation of oxidative stress to initiate or prevent OSMF. To assess the scope for mechanism-based approaches to prevent or reverse OSMF, we systematically evaluated the existing literature and investigated the role of oxidative stress in the pathogenesis and chemoprevention of OSMF. A search for relevant articles on PubMed and Scopus was undertaken using pre-defined inclusion and exclusion criteria. A total of 78 articles were selected in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines. The articles eligible for assessment investigated both OSMF and/or oxidative stress biomarkers or specific antioxidants. Both in vitro and human studies consistently demonstrated variations in oxidative stress biomarker levels in OSMF and revealed an increase in oxidative stress, paralleling the development of the disease. Furthermore, the use of antioxidant supplements was overall associated with an improvement in clinical outcomes. Having identified the significance of oxidative stress in OSMF and the therapeutic potential of antioxidant supplements, this scoping review highlights the need for further well-designed studies in the development of mechanism-based interventions for managing OSMF.

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“…The included studies had found a statistically significant increase in serum MDA levels in OSMF patients compared with controls (p < 0.001). 1,18,20,22,26,28,29,30,31,32,33,34,35,36,37,38 Similarly, other studies also observed a significant difference p-value <0.01 4 and p-value <0.05. 39,40 A few studies have also reported significantly higher salivary MDA levels in OSMF compared with healthy subjects (p < 0.001).…”

Section: Discussionmentioning

confidence: 73%

A Meta-Analysis in Assessing Oxidative Stress Using Malondialdehyde in Oral Submucous Fibrosis

et al. 2021

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Objective This study aims to evaluate the oxidative stress marker Malondialdehyde (MDA) in oral submucous fibrosis with available literature. Materials and Methods We conducted a literature search electronically in PubMed (MeSH), Science Direct, Scopus, and Google Scholar using specific keywords. Results A systematic search in PubMed, Science Direct, and Google Scholar identified 334 articles. Of these, four were duplicate reports, and three were animal studies. After reading the abstracts of the collected articles, 288 articles were excluded for the following reasons: low quality, not relevant to the research question, or did not meet the inclusion criteria. The remaining 46 articles were chosen for full-text assessment. Finally, the present qualitative synthesis included 23 articles for evaluation. The selected studies in MDA analysis in a random-effects model showed higher heterogeneity (Q = 477.636, p < 0.001, I2 = 95.394%). The standard difference in mean MDA concentration between oral submucous fibrosis (OSMF) and healthy subjects was estimated as 2.73 nmol/mL (95% confidence interval: 2.08–3.38). Conclusion The selected studies showed significantly higher MDA levels in various biological samples of patients with OSMF. Therefore, further studies are needed to estimate oxidative stress levels by using different biomarkers in OSMF to direct future therapy.

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Oral submucous fibrosis: A quantitative assessment of serum malondialdehyde, superoxide dismutase and correlation with clinical staging

Cited by 9 publications

References 17 publications

Evaluation of Salivary Superoxide Dismutase Levels in Oral Submucous Fibrosis – A Cross Sectional Study

Evaluation of Salivary Superoxide Dismutase Levels in Oral Submucous Fibrosis – A Cross Sectional Study

A Comprehensive Analysis of the Role of Oxidative Stress in the Pathogenesis and Chemoprevention of Oral Submucous Fibrosis

A Meta-Analysis in Assessing Oxidative Stress Using Malondialdehyde in Oral Submucous Fibrosis

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