Oral Coenzyme Q10 Supplementation in Patients with Nonalcoholic Fatty Liver Disease: Effects on Serum Vaspin, Chemerin, Pentraxin 3, Insulin Resistance and Oxidative Stress

Hepatoprotective effect of taurine and coenzyme Q10 and their combination against acrylamide-induced oxidative stress in rats

“…Up regulation of pro-inflammatory cytokine expression can also be associated with the generation of free radicals in macrophages at the inflammation stage [12]. The plasma levels of the pro-inflammatory cytokines TNF-α, IL-1β and IL-6 were significantly increased in AA group, revealing hepatic injury; as well as over production of ROS.…”

The effects of coenzyme Q10 administration on glucose homeostasis parameters, lipid profiles, biomarkers of inflammation and oxidative stress in patients with metabolic syndrome

“…In the present study, we used a randomized clinical trial sample size calculation formula where type one (α) and type two errors (β) were 0.05 and 0.20 (power = 80 %), respectively. According to a previous trial [16], we used 0.04 as SD and 0.03 as the change in mean (d) of the homeostasis model of assessment-insulin resistance (HOMA-IR) as a main variable. Based on the formula, we needed 25 subjects in each group; after considering 5 dropouts in each group, the final sample size was 30 patients in each group.…”

The effect of coenzyme Q10 supplementation on oxidative stress: A systematic review and meta‐analysis of randomized controlled clinical trials

“…Although several randomized controlled trials (RCTs) investigated the effect of CoQ10 supplementation on oxidative stress, a considerable controversy exists over this subject. Some studies indicated that CoQ10 supplementation had some beneficial impacts on oxidative stress (Fakhrabadi, Ghotrom, Mozaffari‐Khosravi, Nodoushan, & Nadjarzadeh, 2014; Farhangi, Alipour, Jafarvand, & Khoshbaten, 2014; Gholnari et al, 2018; Sanoobar et al, 2013), whereas no significant effect was observed in other surveys (Abdollahzad, Aghdashi, Jafarabadi, & Alipour, 2015; Dai et al, 2011). For example, a significant reduction was reported in MDA level among patients with relapsing–remitting multiple sclerosis (Sanoobar et al, 2013) and rheumatoid arthritis (Abdollahzad et al, 2015) following the CoQ10 supplementation.…”

“…For example, a significant reduction was reported in MDA level among patients with relapsing–remitting multiple sclerosis (Sanoobar et al, 2013) and rheumatoid arthritis (Abdollahzad et al, 2015) following the CoQ10 supplementation. However, no significant impact was found on MDA among patients with nonalcoholic fatty liver disease (NAFLD) (Farhangi et al, 2014). The results of another study among diabetic patients with neuropathic signs demonstrated a significant increase in TAC concentration after supplementation with CoQ10 (Fakhrabadi et al, 2014), while a significant reduction in TAC concentration was found among patients with NAFLD (Farhangi et al, 2014).…”