The effects of coenzyme Q10 administration on glucose homeostasis parameters, lipid profiles, biomarkers of inflammation and oxidative stress in patients with metabolic syndrome

Raygan, Fariba; Rezavandi, Zohreh; Tehrani, Sahar Dadkhah; Farrokhian, Alireza; Asemi, Zatollah

doi:10.1007/s00394-015-1042-7

Cited by 84 publications

(77 citation statements)

References 31 publications

(39 reference statements)

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“…This study indicated that CoQ10 supplementation in subjects with PCOS for 12 weeks resulted in significant reductions in FPG, serum insulin, HOMA‐IR and HOMA‐B and a significant increase in QUICKI compared with the placebo. We have previously demonstrated that supplementation with 100 mg/day CoQ10 among subjects with MetS for 8 weeks had beneficial effects on markers of insulin metabolism . In addition, 200 mg/day CoQ10 supplementation in patients with T2DM for 12 weeks led to a significant improvement in glycaemic control .…”

Section: Discussionmentioning

confidence: 95%

“…Previously, the beneficial effects of CoQ10 supplementation on metabolic profiles among subjects without PCOS have been evaluated. We have shown that the intake of 100 mg/day CoQ10 supplements among subjects with MetS for 8 weeks had beneficial effects on markers of insulin metabolism . In addition, a significant improvement in glycaemic control was seen following the supplementation of 200 mg/day CoQ10 in patients with T2DM for 12 weeks .…”

Section: Introductionmentioning

confidence: 89%

“…We have shown that the intake of 100 mg/day CoQ10 supplements among subjects with MetS for 8 weeks had beneficial effects on markers of insulin metabolism. 8 In addition, a significant improvement in glycaemic control was seen following the supplementation of 200 mg/day CoQ10 in patients with T2DM for 12 weeks. 9 In another study by Zahedi et al 10 was observed that treatment with 150 mg/day CoQ10 among persons with T2DM for 12 weeks significantly decreased triglycerides and HDL-cholesterol levels and significantly increased LDLcholesterol levels.…”

Section: Introductionmentioning

confidence: 98%

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The effects of coenzyme Q10 supplementation on glucose metabolism and lipid profiles in women with polycystic ovary syndrome: a randomized, double‐blind, placebo‐controlled trial

Samimi

Mehrizi

Foroozanfard

et al. 2017

Clinical Endocrinology

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 98%

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The effects of coenzyme Q10 supplementation on glucose metabolism and lipid profiles in women with polycystic ovary syndrome: a randomized, double‐blind, placebo‐controlled trial

Samimi

Mehrizi

Foroozanfard

et al. 2017

Clinical Endocrinology

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“…CoQ10 is widely used as a dietary supplement and the oral doses of CoQ10 in human up to 1200 mg d −1 are reported to be safe . In our clinical trial with dyslipidemic patients, the dosage of CoQ10 supplementation (total of 120 mg d −1 ) was chosen based on previous clinical studies, and consistent with other studies …”

Section: Methodsmentioning

confidence: 99%

Coenzyme Q10 Upregulates Platelet cAMP/PKA Pathway and Attenuates Integrin αIIbβ3 Signaling and Thrombus Growth

Shi

et al. 2019

Molecular Nutrition Food Res

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Scope Platelet integrin αIIbβ3 is the key mediator of atherothrombosis. Supplementation of coenzyme Q10 (CoQ10), a fat‐soluble molecule that exists in various foods, exerts protective cardiovascular effects. This study aims to investigate whether and how CoQ10 acts on αIIbβ3 signaling and thrombosis, the major cause of cardiovascular diseases. Methods and results Using a series of platelet functional assays in vitro, it is demonstrated that CoQ10 reduces human platelet aggregation, granule secretion, platelet spreading, and clot retraction. It is further demonstrated that CoQ10 inhibits platelet integrin αIIbβ3 outside‐in signaling. These inhibitory effects are mainly mediated by upregulating cAMP/PKA pathway, where CoQ10 stimulates the A2A adenosine receptor and decreases phosphodiesterase 3A phosphorylation. Moreover, CoQ10 attenuates murine thrombus growth and vessel occlusion in a ferric chloride (FeCl3)‐induced thrombosis model in vivo. Importantly, the randomized, double‐blind, placebo‐controlled clinical trial in dyslipidemic patients demonstrates that 24 weeks of CoQ10 supplementation increases platelet CoQ10 concentrations, enhances the cAMP/PKA pathway, and attenuates αIIbβ3 outside‐in signaling, leading to decreased platelet aggregation and granule release. Conclusion Through upregulating the platelet cAMP/PKA pathway, and attenuating αIIbβ3 signaling and thrombus growth, CoQ10 supplementation may play an important protective role in patients with risks of cardiovascular diseases.

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“…15 In overweight or obese patients with type 2 diabetes, supplementation with CoQ10 (200 mg/day for 3 months) significantly reduced HbA1c levels (mean baseline HbA1c reduced by 0.7%) and decreased weight and waist circumference. 16 The question arises as to how CoQ10 might directly influence glycaemic homeostasis.…”

Section: Coenzyme Q10 (Coq10)mentioning

confidence: 99%

Coenzyme Q10 supplementation for diabetes and its complications: an overview

Mantle¹

2017

Br J Diabetes

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This article reviews the potential role of dietary supplementation with coenzyme Q10 (CoQ10) for the management of patients with type 2 diabetes. The rationale for supplementation with CoQ10 is based on its key roles in cellular energy metabolism and as an antioxidant, and its potential mediation of oxidative stress and inflammation, which have been implicated in the pathogenesis of diabetes. Randomised controlled clinical trials have demonstrated that supplementation with CoQ10 can significantly improve glycaemic control, as well as improving vascular dysfunction. Supplementation with CoQ10 may be of particular importance in type 2 diabetics prescribed statins and in those with fatty liver disease. Supplemental CoQ10 is usually well tolerated, with no significant adverse effects reported in long-term use. The importance of product quality and bioavailability cannot be over-emphasised, since this may be a factor in the disparity of findings from clinical trials supplementing CoQ10.

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The effects of coenzyme Q10 administration on glucose homeostasis parameters, lipid profiles, biomarkers of inflammation and oxidative stress in patients with metabolic syndrome

Abstract: www.irct.ir : IRCT201502245623N35.

Cited by 84 publications

References 31 publications

The effects of coenzyme Q10 supplementation on glucose metabolism and lipid profiles in women with polycystic ovary syndrome: a randomized, double‐blind, placebo‐controlled trial

The effects of coenzyme Q10 supplementation on glucose metabolism and lipid profiles in women with polycystic ovary syndrome: a randomized, double‐blind, placebo‐controlled trial

Coenzyme Q10 Upregulates Platelet cAMP/PKA Pathway and Attenuates Integrin αIIbβ3 Signaling and Thrombus Growth

Coenzyme Q10 supplementation for diabetes and its complications: an overview

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