The effect of coenzyme Q10 supplementation on oxidative stress: A systematic review and meta‐analysis of randomized controlled clinical trials

Abstract

Some evidence exists in supporting the beneficial effects of coenzyme Q10 (CoQ10) on oxidative stress. Since the findings of studies over the impact of CoQ10 supplementation on oxidative stress are contradictory, this study was conducted. The aim was to evaluate CoQ10 supplementation effect on total antioxidant capacity (TAC), malondialdehyde (MDA), glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) levels using data collected from randomized controlled trials (RCTs). Several databases including PubMed, Web of Science, Google Scholar, and Scopus were comprehensively searched up to 23 January 2019 to identify RCTs. A random-effects model, standardized mean difference (SMD), and 95% confidence interval (CI) were applied for data analysis. According to the meta-analysis results on 19 eligible studies, CoQ10 increased the levels of TAC (SMD = 1.29; 95% CI = 0.35-2.23; p = .007), GPX (SMD = 0.45; 95% CI = 0.17-0.74; p = .002), SOD (SMD = 0.63; 95% CI = 0.29-0.97; p < .0001), and CAT (SMD = 1.67; 95% CI = 0.29-3.10; p = .018) significantly. This supplementation also caused a significant reduction in MDA levels (SMD = −1.12; 95% CI = −1.58 to −0.65; p < .0001). However, the results of SOD and CAT should be stated carefully due to the publication bias. In conclusion, this research indicated that CoQ10 supplementation had beneficial effects on oxidative stress markers. However, further studies are needed to confirm these findings.

Coenzyme Q10 Supplementation Improves Adipokine Levels and Alleviates Inflammation and Lipid Peroxidation in Conditions of Metabolic Syndrome: A Meta-Analysis of Randomized Controlled Trials

“…Coenzyme Q 10 (CoQ 10 ) is a dietary compound with established antioxidant properties and is increasingly investigated for its ameliorative effects against various metabolic complications. Evidence from other RCTs has been synthesized to inform on the impact of CoQ 10 on inflammation, oxidative stress, or insulin resistance [28][29][30][66][67][68], including its modulation of adiponectin [31]. However, the current meta-analysis provides novel findings on the broad effects of this compound on the regulation of various adipokines on diverse metabolic complications.…”

Effect of Dietary Coenzyme Q10 Plus NADH Supplementation on Fatigue Perception and Health-Related Quality of Life in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial

“…Among individuals suffering from a wide range of illnesses, researchers have also reported reductions in reactive oxygen and nitrogen species levels (ROS/RNS), protein carboxylation, DNA damage, protein nitration, and lipid peroxidation following CoQ10 supplementation [ 33 , 34 ]. Other in vivo evidence of reduced levels of oxidative and nitrosative stress following CoQ10 supplementation includes downregulation of iNOS enzyme and NF-kB [ 35 , 36 ]. Coenzyme Q10 has been shown to reduce markers of systemic inflammation in several metabolic, autoimmune, and neurological disorders [ 37 , 38 ].…”

Systematic Understanding of Anti-Aging Effect of Coenzyme Q10 on Oocyte Through a Network Pharmacology Approach

“…CoQ10 is one of the representative antioxidants. Several studies have shown that CoQ10 treatment significantly increased the CAT activity, improved preantral follicles viability, and protected ovarian reserve by inhibiting oxidative stress (43)(44)(45).…”