Hepatoprotective effect of taurine and coenzyme Q10 and their combination against acrylamide-induced oxidative stress in rats

Saleh, Afaf Abbass Sayed; Shahin, Mona; Kelada, N. A. H.

doi:10.4314/tjpr.v16i8.14

Cited by 14 publications

(12 citation statements)

References 11 publications

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“…Treatment with CoQ10 revealed a significant decrease in testicular and hepatic MDA levels and a significant increase in testicular and hepatic SOD when compared with the DOX group. These results are accordance with the previous study [49]. Saleh et al concluded that the supplementation of CoQ10 significantly ameliorated liver function and hepatic antioxidant defense capacity and attenuated ROS levels [49].…”

Section: The Central Vein (C) At the Center Of Classic Hepatic Lobule And Cords Of Hepatocytes With Large Rounded Vesicular Nuclei (Arrowsupporting

confidence: 93%

Protective Potential of Ginseng and/or Coenzyme Q10 on Doxorubicin-induced Testicular and Hepatic Toxicity in Rats

Khodir

Alafify

Omar

et al. 2021

Open Access Maced J Med Sci

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Introduction: Although doxorubicin (DOX) is a successful cancer chemotherapeutic, side effects limit the clinical utility of DOX-based therapy, including male infertility and hepatotoxicity. Objective: To evaluate the testicular and hepatoprotective effect of ginseng and/or coenzyme Q10 (CoQ10) in rats exposed to DOX and the possible underlying mechanisms. Materials and Methods: Fifty adult male albino rats were divided into (10/group), control, DOX group, DOX/Gin group, DOX/CoQ10 group and DOX/Gin+CoQ10 group. Serum testosterone, serum liver enzymes, fasting serum cholesterol and triglyceride (TG), tissue malondialdehyde (MDA), tissue superoxide dismutase (SOD), serum tumor necrosis factor-alpha (TNF-α), serum interleukin 6, serum interleukin 10, nuclear factor E2‐related factor 2 (Nrf2) gene expression in liver and testis and organ indices were measured. Histopathological and immunohistochemical assessments of apoptotic marker kaspase3 in testis and liver were also performed. Results DOX-induced toxicity is associated with a significant decrease in serum testosterone, testis and liver index values, testicular and hepatic SOD, testicular and hepatic Nrf2 gene expression and serum interleukin 10. However, there was a significant increase in serum liver enzymes, serum cholesterol and TG, testicular and hepatic MDA, serum TNF-α and serum interleukin 6 when compared with the control group. The combination of ginseng and CoQ10 resulted in significant improvement of DOX-induced changes when compared with other treated groups. Conclusion: Ginseng and CoQ10 have valuable therapeutic effects on DOX-induced testicular and hepatic toxicity via up-regulation of Nrf2 gene expression, inhibition of apoptosis, anti-oxidant, anti-inflammatory and hypolipidemic effects.

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Section: The Central Vein (C) At the Center Of Classic Hepatic Lobule And Cords Of Hepatocytes With Large Rounded Vesicular Nuclei (Arrowsupporting

confidence: 93%

Protective Potential of Ginseng and/or Coenzyme Q10 on Doxorubicin-induced Testicular and Hepatic Toxicity in Rats

Khodir

Alafify

Omar

et al. 2021

Open Access Maced J Med Sci

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“…Malondialdehyde (MDA) is a highly reactive three-carbon dialdehyde, generated as a decomposition product of polyunsaturated fatty acids [ 6 , 39 ]. MDA is frequently investigated index of ROS production, which presents a marker of the overall lipid peroxidation degree [ 9 , 14 , 39 ]. Lipid peroxidation was determined in relation to the quantity of MDA in an admitted assay for measuring the degree of oxidative injury and oxidative stress at the cellular level [ 13 ].…”

Section: Resultsmentioning

confidence: 99%

“…An achievable approach to guard against ROS-induced cellular damage is to enlarge the oxidative protection capability via intake of antioxidants [ 6 ]. Several exogenous antioxidants have been researched in terms of their potential advantages to defend against oxidative injury [ 14 ]. The activity of enzymatic antioxidant systems, including SOD and GSH-PX, could modulate the balance of ROS with antioxidants [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Ubidecarenone-Loaded Nanostructured Lipid Carrier (UB-NLC): Percutaneous Penetration and Protective Effects Against Hydrogen Peroxide-Induced Oxidative Stress on HaCaT Cells

Wang

Xia

2018

IJMS

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The objective of the investigation was to evaluate the percutaneous penetration of a ubidecarenone-loaded nanostructured lipid carrier (UB-NLC) and to illuminate the protective effects of UB-NLC for amelioration of hydrogen peroxide-induced oxidative damage on HaCaT cells. Ubidecarenone (UB) was encapsulated in a nanostructured lipid carrier (NLC), which was manufactured by homogenization. The morphological and dimensional properties of the prepared UB-NLC were studied by freeze-fracture transmission electron microscopy (FF-TEM) and photon correlation spectroscopy (PCS). Percutaneous penetration of UB-NLC was carried out by the Franz diffusion cells method. The change of cellular morphology was identified through a non-invasive time-lapse imaging system. The assessment was achieved via the evaluation of the levels of oxidative stress markers: reactive oxygen species (ROS), superoxide dismutase (SOD), glutathione peroxidase (GSH-PX), and malondialdehyde (MDA). Percutaneous penetration of UB loaded in NLC formulation was enhanced in comparison to free UB. Preincubation of HaCaT cells with UB-NLC attenuated the level of intracellular generation of ROS. Lipid peroxidation was diminished by UB-NLC via inhibition of MDA formation. Pretreatment of cells with UB-NLC reestablished the activity of cellular antioxidant enzymes (SOD and GSH-PX). On the basis of the investigation conducted, results suggest that formulating UB as NLC is advantageous for topical delivery and treatment of oxidative stress-induced human diseases.

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“…Saleh и соавт. [49] на модели повреждения печени после однократного перорального приема акриламида в дозе 15 мг/кг. На этом фоне животные получали коэнзим Q10 в дозе 200 мг/кг/сут перорально.…”

Section: обзоры литературыunclassified

“…В качестве биохимических показателей повреждения печени оценивался уровень ферментов АлАТ, АсАТ, лактатдегидрогиназы, показатели окислительного стресса: уровень восста-новленного глутатиона, малонового диальдегида, миелопероксидазы, а также провоспалительных цитокинов: ИЛ-1B, ИЛ-6, ФНО-альфа. Прием коэнзима Q10 уже через 2 нед достоверно снижал уровень маркеров повреждения печени, уровень провоспалительных цитокинов и показателей окислительного стресса [49].…”

Section: обзоры литературыunclassified

Metabolic markers and oxidative stress in children’s obesity pathogenesis

Povarova

Городецкая

Kalenikova

et al. 2020

Ross. vestn. perinatol. pediatr.

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The article presents a modern view of obesity as a chronic inflammation of adipose tissue. Obesity is accompanied by metabolic changes in lipid, protein, carbohydrate, mineral metabolism and disorders in the hormonal function of adipose tissue as an endo- and paracrine organ. At the moment, there are searched the biochemical markers of metabolic disorders of obesity. The obesity-related factors (hyperglycemia, increased lipid levels, insulin resistance, chronic inflammation, hyperleptinemia, endothelial dysfunction, impaired respiratory function of mitochondria, minerals and microelements deficiency) form and increase oxidative stress making it an integral component of the pathogenesis of obesity and possible complications. Given the important role of Q10 coenzyme in antioxidant tissue protection, the authors discuss the relationship of obesity and metabolic disorders to the endogenous levels of Q10 coenzyme and its possible use for pharmacological correction.

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Hepatoprotective effect of taurine and coenzyme Q10 and their combination against acrylamide-induced oxidative stress in rats

Abstract: Purpose: To clarify the protective effects of Taurine (TA)

Cited by 14 publications

References 11 publications

Protective Potential of Ginseng and/or Coenzyme Q10 on Doxorubicin-induced Testicular and Hepatic Toxicity in Rats

Protective Potential of Ginseng and/or Coenzyme Q10 on Doxorubicin-induced Testicular and Hepatic Toxicity in Rats

Ubidecarenone-Loaded Nanostructured Lipid Carrier (UB-NLC): Percutaneous Penetration and Protective Effects Against Hydrogen Peroxide-Induced Oxidative Stress on HaCaT Cells

Metabolic markers and oxidative stress in children’s obesity pathogenesis

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