Novel nanostructural photosensitizers for photodynamic therapy: In vitro studies

Nawalany, Kinga; Rusin, Aleksandra; Kępczyński, Mariusz; Filipczak, Piotr T.; Kumorek, Marta; Kozik, Bartłomiej; Weitman, Hana; Ehrenberg, Benjamin; Krawczyk, Z; Nowakowska, Maria

doi:10.1016/j.ijpharm.2012.04.016

Cited by 39 publications

(25 citation statements)

References 47 publications

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“…Based on our findings of substantial measured levels of H 2 O 2 and selective inhibition of Cal-G release by ascorbic acid (AA) and K 3 Fe(CN) 6 , but not that by NaN 3 , we conclude that the 514 nm laser-triggered release of entrapped Cal-G from our formulated liposomes depends on a photoactivated state of Cal-G, which utilizes the type I photoactivation-reaction pathway. Understanding of the light-triggered release mechanisms is highly advantageous for the suitable design of future nanodelivery systems in biology and medical applications.…”

Section: Introductionmentioning

confidence: 71%

“…The clear supernatant was used further. 3 H-inulin was reconstituted in MilliQ water (Millipore) at a concentration of 1 µCi/µL.…”

Section: Inulin Encapsulationmentioning

confidence: 99%

“…The liposomes were placed in a precooled Eppendorf tube and irradiated horizontally with a focused beam intensity of 166 mW/cm 2 with 0-to 10-minute laserexposure durations. 22 For inulin release, samples were treated in quadruplicate and pooled together for monitoring the 3 H-inulin release (see 3 H-inulin release section below).…”

Section: Light Treatmentmentioning

confidence: 99%

“…However, as noted in the separate parallel experiments without the laser irradiation, that addition of copious levels of exogenous H 2 O 2 to the DPPC:DC 8,9 PC liposomes did not result in any enhanced Cal-G release, thus leading us to rule out H 2 O 2 as the key player in the permeabilization of the liposome membrane. In a type II pathway the excited photo-agent Cal-G is expected to transfer its excited energy onto the ground (triplet) state, 3 O 2 , resulting in an excited oxygen molecule in its singlet state 1 O 2 . However, as noted above, our singlet oxygenscavenger studies have revealed that singlet oxygen is not a key player responsible for the enhanced permeabilization of the liposome lipid membrane.…”

Section: Sodium Azide a Singlet Oxygen Scavenger Does Not Block 514mentioning

confidence: 99%

“…[1][2][3][4] Several studies have described the synthesis and properties of photoreactive molecules (primarily lipids) designed to enhance localized drug delivery (triggered release) upon activation by a suitable light source (photo-triggering). [5][6][7][8][9][10][11][12] Photo-triggering typically involves activation of the photosensitive molecules, causing a perturbation (destabilization) of the liposome membrane.…”

Section: Introductionmentioning

confidence: 99%

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Low-visibility light-intensity laser-triggered release of entrapped calcein from 1,2-bis (tricosa-10,12-diynoyl)-sn-glycero-3-phosphocholine liposomes is mediated through a type I photoactivation pathway

Puri¹,

Viard²,

Viard³

et al. 2013

IJN

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Section: Introductionmentioning

confidence: 71%

“…The clear supernatant was used further. 3 H-inulin was reconstituted in MilliQ water (Millipore) at a concentration of 1 µCi/µL.…”

Section: Inulin Encapsulationmentioning

confidence: 99%

Section: Light Treatmentmentioning

confidence: 99%

Section: Sodium Azide a Singlet Oxygen Scavenger Does Not Block 514mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Low-visibility light-intensity laser-triggered release of entrapped calcein from 1,2-bis (tricosa-10,12-diynoyl)-sn-glycero-3-phosphocholine liposomes is mediated through a type I photoactivation pathway

Puri¹,

Viard²,

Viard³

et al. 2013

IJN

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Long Wavelength Light Activated Prodrug Conjugates for Biomedical Applications

et al. 2018

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Long wavelength light (LWL) activated prodrug conjugates are a promising system to prevent systemic side effects and reduce drug resistance in cancer therapy. These systems have been applied for spatiotemporal-and dose-controlled drug release under low-energy LWL irradiation. Compared with other drug release systems, LWL-activated prodrug conjugates offer deeptissue cancer therapies at the desired site and time with excitation only by LWL. Therefore, the fabrication of LWLactivated prodrug conjugates is highly important. To achieve this goal, a LWL transducer that could convert LWL into an ondemand stimulus for prodrug activation was proposed. This Minireview summarizes the latest developments of light transduction and the application in LWL-activated prodrug conjugates for biomedical applications. Design of LWL-Activated Prodrug ConjugatesIdeally, LWL-activated prodrug conjugates provide targeted drug release under lower energy light irradiation. In order to design effective LWL-activated prodrug conjugates, the following principle should be fulfilled: the prodrug conjugates are composed of a LWL-sensitive transducer, caged chemotherapeutic drugs and specific stimuli-responsive linkers. When conjugates are exposed to LWL irradiation, the transducers

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Star‐Shaped Polymer Consisting of a Porphyrin Core and Poly(L‐lysine) Dendron Arms: Synthesis, Drug Delivery, and In Vitro Chemo/Photodynamic Therapy

Liu

Qin

et al. 2013

Macromol. Rapid Commun.

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A novel star-shaped polymer, porphyrin-poly(L-lysine) dendrons (PP-PLLD), is synthesized by the click reaction between azido-modified porphyrin and propargyl focal point poly(L-lysine) dendrons. Its chemical structure is characterized by (1) H nuclear magnetic resonance, Fourier transform infrared spectroscopy, and gel permeation chromatography (GPC) is analyses etc. Due to its amphiphilic property, the obtained PP-PLLD has a low critical micelle concentration in an aqueous solution, and can load doxorubicin (DOX) with a loading amount of 64 μg mg(-1) . By in vitro toxicity assay, PP-PLLD has no dark cytotoxicity but has significant phototoxicity. Moreover, DOX-loaded PP-PLLD shows a higher cytotoxicity under the light condition than PP-PLLD or DOX alone, suggesting PP-PLLD has a potential application in combined photodynamic therapy and chemotherapy.

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Novel nanostructural photosensitizers for photodynamic therapy: In vitro studies

Cited by 39 publications

References 47 publications

Low-visibility light-intensity laser-triggered release of entrapped calcein from 1,2-bis (tricosa-10,12-diynoyl)-sn-glycero-3-phosphocholine liposomes is mediated through a type I photoactivation pathway

Low-visibility light-intensity laser-triggered release of entrapped calcein from 1,2-bis (tricosa-10,12-diynoyl)-sn-glycero-3-phosphocholine liposomes is mediated through a type I photoactivation pathway

Long Wavelength Light Activated Prodrug Conjugates for Biomedical Applications

Star‐Shaped Polymer Consisting of a Porphyrin Core and Poly(L‐lysine) Dendron Arms: Synthesis, Drug Delivery, and In Vitro Chemo/Photodynamic Therapy

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