New Resorbable Membrane Materials for Guided Bone Regeneration

Jo, You‐Young; Oh, Ji-Hyeon

doi:10.3390/app8112157

Cited by 19 publications

(15 citation statements)

References 70 publications

(125 reference statements)

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“…Platelet-rich fibrin (PRF) is a second-generation platelet concentrate that can be isolated by centrifugation from autogenous blood. PRF is an autogenous fibrin clot rich in platelets and does not require factors such as bovine thrombin [21]. The use of PRP gels (fibrin) in bone defects does not enhance healing of the bone defect compared to non-treated defects [22].…”

Section: Introductionmentioning

confidence: 99%

Bone Regeneration in Peri-Implant Defect Using Autogenous Tooth Biomaterial Enriched with Platelet-Rich Fibrin in Animal Model

et al. 2020

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Tooth biomaterial may be useful in bone regeneration for restoring peri-implant defects in vivo. The aim of this study was to compare bone regeneration capacity in peri-implant defects augmented with autogenous tooth biomaterial combined with platelet-rich fibrin (PRF), tooth biomaterial alone, or PRF alone. Two monocortical defects were generated on each tibia of 10 New Zealand white rabbits (n = 10 per group) with a trephine bur, and the dental implant was installed into the defects. In experimental groups 1, 2, and 3, the peri-implant defects were filled with tooth biomaterial and platelet-rich fibrin (PRF), tooth biomaterial only, and PRF only, respectively and the control was left empty. Micro computed tomography (CT), implant stability, and histomorphometric analysis were conducted eight weeks after operation. The mean regenerated bone areas were 53.87 ± 7.60%, 51.56 ± 6.45%, and 18.45 ± 1.34% in experimental groups 1, 2, and 3, respectively, and 11.57 ± 1.12% in the control. Mean bone-to-implant contact values were 43.67 ± 2.50%, 41.07 ± 2.59%, and 21.45 ± 1.25% in experimental groups 1, 2, and 3, respectively, and 16.57 ± 2.83% in the control. Tooth biomaterial enriched with platelet-rich fibrin (PRF) and tooth biomaterial alone showed more enhanced regeneration than PRF alone in our study.

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Section: Introductionmentioning

confidence: 99%

Bone Regeneration in Peri-Implant Defect Using Autogenous Tooth Biomaterial Enriched with Platelet-Rich Fibrin in Animal Model

et al. 2020

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“…Guided tissue regeneration (GTR) membranes are typically used to block the migration of fast-growing connective tissue into the bony defect and to create space for the regeneration of slow-growing alveolar bone and periodontal ligament [5]. Over the years, the materials of the GTR barrier matrix from non-resorbable polytetrafluoroethylene-like expanded e-PTFE or dense d-PTFE [6] and titanium mesh [7], evolved to resorbable polymer to dispense with the operation of secondary GTR removal [8,9]. Most commercial resorbable synthetic polymer membranes are based on aliphatic polyesters, such as poly(lactic acid) (PLA), poly(glycolic acid) (PGA), poly(ε-caprolactone) (PCL), or their copolymers, to match the resorption time period for various clinical needs [10].…”

Section: Introductionmentioning

confidence: 99%

In Vitro and In Vivo Studies of Hydrophilic Electrospun PLA95/β-TCP Membranes for Guided Tissue Regeneration (GTR) Applications

et al. 2019

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The guided tissue regeneration (GTR) membrane is a barrier intended to maintain a space for alveolar bone and periodontal ligament tissue regeneration but prevent the migration of fast-growing soft tissue into the defect sites. This study evaluated the physical properties, in vivo animal study, and clinical efficacy of hydrophilic PLA95/β-TCP GTR membranes prepared by electrospinning (ES). The morphology and cytotoxicity of ES PLA95/β-TCP membranes were evaluated by SEM and 3-(4,5-cimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) respectively. The cementum and bone height were measured by an animal study at 8 and 16 weeks after surgery. Fifteen periodontal patients were selected for the clinical trial by using a commercial product and the ES PLA95/β-TCP membrane. Radiographs and various indexes were measured six months before and after surgery. The average fiber diameter for this ES PLA95/β-TCP membrane was 2.37 ± 0.86 µm. The MTT result for the ES PLA95/β-TCP membrane showed negative for cytotoxicity. The significant differences in the cementum and bone height were observed between empty control and the ES PLA95/β-TCP membrane in the animal model (p < 0.05). Clinical trial results showed clinical attachment level (CAL) of both control and ES PLA95/β-TCP groups, with a significant difference from the pre-surgery results after six months. This study demonstrated that the ES PLA95/β-TCP membrane can be used as an alternative GTR membrane for clinical applications.

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“…Several natural and synthetic membranes have been commercialized for biomedical applications (6,7), including polytetrafluoroethylene (PTFE), expanded PTFE, natural collagen, freeze-dried fascia lata, freeze-dried dura mater allografts, polylactic acid, polyglycolic acid, polyorthoester, polyurethane, polyhydroxybutyrate, calcium sulfate, titanium mesh, and titanium foils; but natural type-I collagen is the preferred choice (8,9). The membrane helps to create a space for fibroblasts and osteoblasts to remodel the damaged tissues (7).…”

Section: Introductionmentioning

confidence: 99%

Properties of a bovine collagen type I membrane for guided bone regeneration applications

et al. 2021

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Dental implant treatment requires an available bone volume in the implantation site to ensure the implant’s mechanical stability. When the bone volume is insufficient, one must resort to surgical means such as guided bone regeneration (GBR). In GBR surgery, bone grafts and membranes are used. The objective of this work is to manufacture and characterize the in vitro and in vivo properties of resorbable collagen type I membranes (Green Membrane®) for GBR. Membrane surface morphology was characterized by SEM and roughness was measured using an interferometric noncontact 3D system. In vivo skin sensitization and toxicity tests have been performed on Wistar rats. Bone defects were prepared in 24 adult male rats, filled with biomaterials (Blue Bone® and Bio Oss®) and covered with collagen membranes to maintain the mechanical stability of the site for bone regeneration. The incisions were closed with simple stitches; and 60 days after the surgery, the animals were euthanized. Results showed that the analyzed membrane was homogeneous, with collagen fiber webs and open pores. It had no sign of cytotoxicity and the cells at the insertion site showed no bone morphological changes. There was no tissue reaction and no statistical difference between Blue Bone® and Bio Oss® groups. The proposed membrane has no cytotoxicity and displays a biocompatibility profile that makes it suitable for GBR.

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New Resorbable Membrane Materials for Guided Bone Regeneration

Cited by 19 publications

References 70 publications

Bone Regeneration in Peri-Implant Defect Using Autogenous Tooth Biomaterial Enriched with Platelet-Rich Fibrin in Animal Model

Bone Regeneration in Peri-Implant Defect Using Autogenous Tooth Biomaterial Enriched with Platelet-Rich Fibrin in Animal Model

In Vitro and In Vivo Studies of Hydrophilic Electrospun PLA95/β-TCP Membranes for Guided Tissue Regeneration (GTR) Applications

Properties of a bovine collagen type I membrane for guided bone regeneration applications

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