Neuroprotective Effect of Matricaria chamomilla Extract on Motor Dysfunction Induced by Transient Global Cerebral Ischemia and Reperfusion in Rat

Moshfegh, Azam; Setorki, Mahbubeh

doi:10.5812/zjrms.10927

Cited by 6 publications

(6 citation statements)

References 24 publications

(26 reference statements)

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“…Matricaria chamomilla extract has been shown in several studies to reduce lipid peroxidation (as measured by MDA levels) and raise serum levels of SOD, catalase, and glutathione [14,26,27]. However, in the present study, the administration of MC along with MTX exhibited no significant difference in the serum levels of MDA, CAT, and SOD in contrast to other studied groups.…”

Section: Discussioncontrasting

confidence: 84%

Effect of Methotrexate and Matricaria Chamomile on testis tissue and some antioxidants in Albino rats

AL-Ali¹,

Almuttairi²,

Al-Aaraji³

et al. 2022

Journal of Pharmaceutical Negative Results

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Objective: Depending on the antioxidant as well as anti-inflammatory properties of Matricaria Chamomile (MC), the current study aimed to investigate if MC could protect testicles against methotrexate (MTX)-induced testicular damage. Methods: 24 male Wistar albino rats were randomly separated into four groups (n=6/each) as follows. G1, the control group was given a single oral daily dose of distilled water (D.W) for 30 days; G2, (MTX group) rats were administered a single oral daily dose of D.W. and in day 28 the animals have received a single IP dosage of MTX; G3 six rats were given an aqueous extract of chamomile flowers at a dose of 200 mg/kg dissolved in 1 ml D.W. and on day 28 the rats have received a single intraperitoneal dose of MTX, and the last group was six rats received a methanolic extract of chamomile flowers at a dose of 200 mg/kg dissolved in 1 ml D.W. and on the day 28 the animals were received a one dosage intraperitoneal of MTX. At the end of the experiment, all animals were anesthetized and sacrificed, blood was also collected for the biochemical test as well as the testicular tissues were removed for histology examination. Results: According to biochemical assessments, notably there was no significant difference between the MTX and the other studied groups. In terms of histological examinations of animals treated with MTX, several pathological changes including vacuolization of seminiferous tubules with a reduced population of germinal epithelium were seen as compared to the control. Animals of G3 and G4 (pre-treatment with equates and alcoholic extract of MC before MTX administration) also showed some notable histopathological changes including disorganization of seminiferous tubules and tubular vacuolation. Conclusion: When comparing the control group, examination of testes with H&E staining showed that pre-treatment with Matricaria Chamomile did not affect MTX-induced testicular damage.

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Section: Discussioncontrasting

confidence: 84%

Effect of Methotrexate and Matricaria Chamomile on testis tissue and some antioxidants in Albino rats

AL-Ali¹,

Almuttairi²,

Al-Aaraji³

et al. 2022

Journal of Pharmaceutical Negative Results

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“…Hence, in the current study the effect on memory was assessed using plus maze and Morris water maze. Also, cerebral IR injury is associated with impairment of balance and motor coordination, which, in present study, was investigated using inclined beam test and rota rod test (Grewal et al 2013;Moshfegh and Setorki 2017).…”

Section: Discussionmentioning

confidence: 97%

“…Cerebral IR injury is associated with impairment of balance and motor coordination, which, in present study, was investigated using inclined beam test and rota rod test(Grewal et al 2013;Moshfegh and Setorki 2017). For evaluation of neuroprotective effects resveratrol PoCo on motor performance, the fall down time, after ischemia of 17 min and reperfusion for 24 h, wasobserved.…”

mentioning

confidence: 99%

Effects of resveratrol postconditioning on cerebral ischemia in mice: role of the sirtuin-1 pathway

Grewal

Singh

2019

Can. J. Physiol. Pharmacol.

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Evidence has demonstrated that resveratrol preconditioning exhibits neuroprotection against cerebral ischemia–reperfusion (IR) injury. The current investigation aimed to explore whether pharmacological postconditioning, by administering resveratrol, after a sustained ischemia and prior to prolonged reperfusion abrogates cerebral IR injury. Cerebral IR-induced injury mice model was employed in this study to evaluate the neuroprotective effects of pharmacological postconditioning with resveratrol (30 mg/kg; i.p.) administered 5 min before reperfusion. We administered sirtinol, a SIRT1/2 selective inhibitor (10 mg/kg; i.p.) 10 min before ischemia (17 min) and reperfusion (24 h), to elucidate whether the neuroprotection with resveratrol postconditioning depends on SIRT1 activation. Various biochemical and behavioural parameters and histopathological changes were assessed to examine the effect of pharmacological postconditioning. Infarct size is estimated using TTC staining. It was established that resveratrol postconditioning abrogated the deleterious effects of IR injury expressed with regard to biochemical parameters of oxidative stress (TBARS, SOD, GSH), acetylcholinesterase activity, behavioural parameters (memory, motor coordination), infarct size, and histopathological changes. Sirtinol significantly reversed the effect of resveratrol postconditioning. We conclude that induced neuroprotective benefits of resveratrol postconditioning may be the consequence of SIRT1 activation and resveratrol can be considered, for further studies, as potential agent inducing pharmacological postconditioning in clinical situations.

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“…It was also significantly reduced serum MDA level which elevated by ischemia/reperfusion. However, it possessed no significant effects on the total antioxidant capacity of the brain (hippocampus and cortex) and serum, and serum NO level [73].…”

Section: Matricaria Chamomillamentioning

confidence: 90%

Medicinal Plants with neuroprotective effects

Al-Snafi¹

2021

GSC Biol. and Pharm. Sci.

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Neuroprotection is the preservation of the structure and function of neurons from insults from cellular injuries caused by a variety of agents or neurodegenerative diseases. Medicinal plants possess neuroprotective effects via mechanisms that include inhibiting protein-based deposit accumulation, oxidative stress, and neuroinflammation, and correcting defects of neurotransmitters such as acetylcholine and dopamine [1-3]. The current review will highlight the neuroprotective effects of medicinal plants.

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Neuroprotective Effect of Matricaria chamomilla Extract on Motor Dysfunction Induced by Transient Global Cerebral Ischemia and Reperfusion in Rat

Cited by 6 publications

References 24 publications

Effect of Methotrexate and Matricaria Chamomile on testis tissue and some antioxidants in Albino rats

Effect of Methotrexate and Matricaria Chamomile on testis tissue and some antioxidants in Albino rats

Effects of resveratrol postconditioning on cerebral ischemia in mice: role of the sirtuin-1 pathway

Medicinal Plants with neuroprotective effects

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