Effects of resveratrol postconditioning on cerebral ischemia in mice: role of the sirtuin-1 pathway

Grewal, Amarjot Kaur; Singh, Nirmal; Singh, Thakur Gurjeet

doi:10.1139/cjpp-2019-0188

Cited by 31 publications

(11 citation statements)

References 72 publications

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“…Among them, 86 records were excluded due to review, abstracts without full text, not having purified resveratrol, no in vivo experiment, not reporting the number of animals in groups, and or no adequate outcomes (infarction volume or functional outcome determined by neurobehavioral score measured on any scale/rotarod test). Therefore, 54 studies ( Huang et al, 2001 ; Sinha et al, 2002 ; Inoue, 2003 ; Gao et al, 2006 ; Tsai et al, 2007 ; Dong et al, 2008 ; Yousuf et al, 2009 ; Li et al, 2010 ; Sakata et al, 2010 ; Shin et al, 2010 ; Ren et al, 2011 ; Li et al, 2012 ; Shin et al, 2012 ; Hurtado et al, 2013 ; Lanzillotta et al, 2013 ; Lin et al, 2013 ; Orsu et al, 2013 ; Yan et al, 2013 ; Saleh et al, 2014 ; Wang et al, 2014 ; Fang et al, 2015 ; Hermann et al, 2015 ; Ishrat et al, 2015 ; Koronowski et al, 2015 ; Li et al, 2015 ; Narayanan et al, 2015 ; Pandey et al, 2015 ; Pang et al, 2015 ; Abdel-Aleem et al, 2016 ; Jeong et al, 2016 ; Li et al, 2016 ; Lopez et al, 2016 ; Su et al, 2016 ; Wan et al, 2016 ; Yang et al, 2016 ; Al Dera, 2017 ; He et al, 2017 ; Koronowski et al, 2017 ; Yu et al, 2017 ; Faggi et al, 2018 ; Hou et al, 2018 ; Liu et al, 2018 ; Dou et al, 2019 ; Grewal et al, 2019 ; Park et al, 2019 ; Yan et al, 2019 ; Alquisiras-Burgos et al, 2020 ; Lu et al, 2020 ; Mota et al, 2020 ; Pineda-Ramírez et al, 2020 ; Teertam et al, 2020 ; Yao et al, 2020 ; McDonald...…”

Section: Resultsmentioning

confidence: 99%

Resveratrol has an Overall Neuroprotective Role in Ischemic Stroke: A Meta-Analysis in Rodents

Liu¹,

He²,

Huang³

et al. 2021

Front. Pharmacol.

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Background: Resveratrol, a natural polyphenolic phytoalexin, is broadly presented in dietary sources. Previous research has suggested its potential neuroprotective effects on ischemic stroke animal models. However, these results have been disputable. Here, we conducted a meta-analysis to comprehensively evaluate the effect of resveratrol treatment in ischemic stroke rodent models.Objective: To comprehensively evaluate the effect of resveratrol treatment in ischemic stroke rodent models.Methods: A literature search of the databases Pubmed, Embase, and Web of science identified 564 studies that were subjected to pre-defined inclusion criteria. 54 studies were included and analyzed using a random-effects model to calculate the standardized mean difference (SMD) with corresponding confidence interval (CI).Results: As compared with controls, resveratrol significantly decreased infarct volume (SMD −4.34; 95% CI −4.98 to −3.69; p < 0.001) and the neurobehavioral score (SMD −2.26; 95% CI −2.86 to −1.67; p < 0.001) in rodents with ischemic stroke. Quality assessment was performed using a 10-item checklist. Studies quality scores ranged from 3 to 8, with a mean value of 5.94. In the stratified analysis, a significant decrease of infarct volume and the neurobehavioral score was achieved in resveratrol sub-groups with a dosage of 20–50 mg/kg. In the meta-regression analysis, the impact of the delivery route on an outcome is the possible source of high heterogeneity.Conclusion: Generally, resveratrol treatment presented neuroprotective effects in ischemic stroke models. Furthermore, this study can direct future preclinical and clinical trials, with important implications for human health.

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Section: Resultsmentioning

confidence: 99%

Resveratrol has an Overall Neuroprotective Role in Ischemic Stroke: A Meta-Analysis in Rodents

Liu¹,

He²,

Huang³

et al. 2021

Front. Pharmacol.

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“…In the presence of the mutant HD protein, the SIRT1-TORC1 interaction was inhibited, repressing BDNF transcription [155]. In addition to providing neuroprotection against neurodegenerative diseases, the activation of SIRT1 has been shown to confer protection against cerebral ischemia [156] and metabolic diseases such as obesity [157] and type 2 diabetes [158].…”

Section: Discussionmentioning

confidence: 99%

The Critical Role of SIRT1 in Parkinson’s Disease: Mechanism and Therapeutic Considerations

et al. 2020

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Silence information regulator 1 (SIRT1), a member of the sirtuin family, targets histones and many non-histone proteins and participates in various physiological functions. The enzymatic activity of SIRT1 is decreased in patients with Parkinson's disease (PD), which may reduce their ability to resist neuronal damage caused by various neurotoxins. As far as we know, SIRT1 can induce autophagy by regulating autophagy related proteins such as AMP-activated protein kinase, light chain 3, mammalian target of rapamycin, and forkhead transcription factor 1. Furthermore, SIRT1 can regulate mitochondrial function and inhibit oxidative stress mainly by maintaining peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) in a deacetylated state and thus maintaining a constant level of PGC-1α. Other studies have demonstrated that SIRT1 may play a role in the pathophysiology of PD by regulating neuroinflammation. SIRT1 deacetylases nuclear factor-kappa B and thus reduces its transcriptional activity, inhibits inducible nitric oxide synthase expression, and decreases tumor necrosis factor-alpha and interleukin-6 levels. SIRT1 can also upregulate heat shock protein 70 by deacetylating heat shock factor 1 to increase the degradation of α-synuclein oligomers. Few studies have focused on the relationship between SIRT1 single nucleotide polymorphisms and PD risk, so this topic requires further research. Based on the neuroprotective effects of SIRT1 on PD, many in vitro and in vivo experiments have demonstrated that some SIRT1 activators, notably resveratrol, have potential neuroprotective effects against dopaminergic neuronal damage caused by various neurotoxins. Thus, SIRT1 plays a critical role in PD development and might be a potential target for PD therapy.

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“…However, more research is needed to develop pathophysiological links. Neuronal α-synuclein expressions in the peripheral nervous system block viral CNS invasion and replication of RNA viruses in the nervous system (Grewal et al, 2019 ). In a preclinical study, α-synuclein knockout mice showed B and T cell deficiencies.…”

Section: Covid-19 and Parkinson’s Diseasementioning

confidence: 99%

Covid-19: pharmacotherapeutic insights on various curative approaches in terms of vulnerability, comorbidities, and vaccination

Kaur

Singh

et al. 2022

Inflammopharmacol

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A novel coronavirus disease (COVID-19), caused by a severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), was discovered in Wuhan, China, in December 2019, and the world has suffered from a pandemic. As of 22nd March 2020, at least 185 countries worldwide had been affected by COVID-19. SARS-CoV-2, leading to COVID-19 pneumonia, infects cells through ACE-2 receptors. The disease has different clinical signs and symptoms, including chills, high fever, dyspnea, and cough. Other symptoms including haemoptysis, myalgia, diarrhoea, expectoration, and fatigue may also occur. The rapid rise in confirmation cases is severe in preventing and controlling COVID-19. In this review, the article will explore and evaluate the insights into how COVID influences patients with other comorbid conditions such as cardiovascular disease, diabetes, Parkinson’s, and how conditions Urolithiasis, anosmia, and anuria may develop after infection. The virus mutates and the variants are now prevalent in the present scenario where the world stands in eradicating the pandemic by looking into the development of vaccines by several countries and how the vaccination can temporarily help prevent COVID spread.

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Effects of resveratrol postconditioning on cerebral ischemia in mice: role of the sirtuin-1 pathway

Cited by 31 publications

References 72 publications

Resveratrol has an Overall Neuroprotective Role in Ischemic Stroke: A Meta-Analysis in Rodents

Resveratrol has an Overall Neuroprotective Role in Ischemic Stroke: A Meta-Analysis in Rodents

The Critical Role of SIRT1 in Parkinson’s Disease: Mechanism and Therapeutic Considerations

Covid-19: pharmacotherapeutic insights on various curative approaches in terms of vulnerability, comorbidities, and vaccination

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