Neonatal Outcomes in Women With Untreated Antenatal Depression Compared With Women Without Depression

Jarde, Alexander; Morais, Michelle; Kingston, Dawn; Giallo, Rebecca; MacQueen, Glenda; Giglia, Lucy; Beyene, Joseph; Wang, Yi; McDonald, Sarah D.

doi:10.1001/jamapsychiatry.2016.0934

Cited by 378 publications

(252 citation statements)

References 45 publications

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“…The presence of these symptoms at high levels can lead to unfavorable maternal and perinatal outcomes. (2)(3)(4)(5) The least frequent was the thought about injuring oneself. However, its presence at all stages shows the importance of a specific screening tool to identify pregnant women at risk.…”

Section: Discussionmentioning

confidence: 99%

“…Depression may persist in the postpartum period and compromise parental behavior, the relationship with the partner and family, the process of mother-child bonding, and the child's cognitive, motor and psychosocial development. (2)(3)(4)(5) Studies on depression and its effects in the prenatal period are recent, dating back two decades, with an increase thereafter.…”

Section: Introductionmentioning

confidence: 99%

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Sintomas depressivos na gestação e fatores associados: estudo longitudinal

et al. 2017

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Objective: To identify the frequency of depressive symptoms during pregnancy and verify their association with sociodemographic, obstetric and health variables. Methods: A longitudinal study conducted with 272 pregnant women in 12 health units in the city of São Paulo. Data were obtained using a form for the independent variables, and the Edinburgh Postpartum Depression Scale applied at the 20 th , 28 th and 36 th gestational weeks. A model of generalized estimating equations was used to evaluate the associated factors and odds ratio. Results: The frequency of depressive symptoms was 27.2%, 21.7% and 25.4%. Higher educational level, planned pregnancy and continuity of gestation were protective factors. Suffering or having suffered psychological violence was an independent risk factor of the gestational period. Conclusion: The frequency of depressive symptoms during pregnancy was high. The associated factors were higher educational level, planned pregnancy, continuity of pregnancy, and suffering or having suffered psychological violence. ResumoObjetivo: Identificar a frequência de sintomas depressivos no decorrer da gestação e verificar sua associação com variáveis sociodemográficas, obstétricas e de saúde. Métodos: Estudo longitudinal realizado com 272 gestantes de 12 unidades de saúde do Município de São Paulo. Os dados foram obtidos por meio de um formulário para as variáveis independentes e da Escala de depressão pós-parto de Edimburgo aplicada nas 20ª, 28ª e 36ª semanas gestacionais. Utilizou-se modelo de equações de estimação generalizadas para avaliar os fatores associados e chances de risco. Resultados: A frequência de sintomas depressivos foi de 27,2%, 21,7% e 25,4%. Maior escolaridade, gestação planejada e continuidade da gestação foram fatores de proteção. Sofrer ou ter sofrido violência psicológica foi fator de risco independente do período gestacional. Conclusão: A frequência de sintomas depressivos na gestação foi elevada. Os fatores associados foram maior escolaridade, gestação planejada, continuidade da gestação e sofrer ou ter sofrido violência psicológica.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sintomas depressivos na gestação e fatores associados: estudo longitudinal

et al. 2017

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“…However, another meta-analysis reported that perinatal depression was associated with a lower gestational age, but not a lower birth weight [39]. One limitation of these two meta-analyses is that they included studies potentially confounded by SSRI medication use, as in these primary studies women taking anti-depressants were not excluded; thus, a more recent meta analysis was conducted to compare neonatal outcomes in pregnant women with depression who did not receive treatment (i.e., pharmacological or nonpharmacological) and women without depression [40]. Results showed that pregnant women with depression who did not receive treatment were at increased risk for lower birth weight compared to women without depression, with a trend toward higher risks with more severe depression.…”

Section: Perinatal Ssris Birth Weight and Maternal Depressionmentioning

confidence: 99%

Perinatal selective serotonin reuptake inhibitor (SSRI) effects on body weight at birth and beyond: A review of animal and human studies

Hutchison

Mâsse

Pawluski

et al. 2018

Reproductive Toxicology

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. Perinatal selective serotonin reuptake inhibitor (SSRI) effects on body weight at birth and beyond A review of animal and human studies. Reproductive Toxicology, Elsevier, 2018, 77, pp.109-121. 10 Highlights  Our paper reviews our current understanding of the impact of prenatal SSRI exposure on weight and growth using both human and animal findings.  Our review extends the previously published review paper by Grzeskowiak and colleagues in Repro Tox in 2012 by including findings beyond infancy, the impact of maternal mood -pre and post natal, and given that the majority our 5HT is in the gastrointestinal (GI) system we speculate that altering 5HT signaling, via SSRI exposure might have an impact on GI function and later weight gain.  With recent advances in our understanding of the gut-brain axis and the role of 5HT, we raise critical questions about how weight and growth outcomes might be related to SSRI induced changes in the GI microbiome.  Our paper provides an updated review of the literature (e.g., Leuner et al 2014;Nezvalová-Henriksen et al., 2016), with a particular focus on weight related outcomes beyond birth, developmental aspects of SSRI exposure that might also impact weight and growth, as well as provides detailed suggestions for future research. AbstractThe long-term impact of selective serotonin reuptake inhibitor (SSRI) antidepressant treatment during pregnancy and postpartum on offspring outcomes is still not clear. Specifically, perinatal SSRI exposure may have long-term consequences for body weight and related health outcomes in the newborn period and beyond. This review focuses on the impact of perinatal SSRI exposure on weight using human and animal findings. The impact of maternal mood is also explored. We propose potential mechanisms for weight changes, including how early alterations in serotonin signaling may have implications for weight via changes in metabolism and motor development.As the majority of serotonin is in the gastrointestinal (GI) system we also speculate that perinatal SSRI exposure might alter the brain-gut relationship, via the microbiome, leading to changes in feeding behavior and weight.

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“…In addition to animal models, a number of human studies have linked maternal distress with adverse birth outcomes, including a greater risk of preterm birth, increased birth-related complications and lower birth weight, as well as longer-term health effects on the offspring [19][20][21]. Maternal distress during pregnancy may also cause long-term effects on the cognitive development of the infant, as well as leading to an increased risk of behavioral problems.…”

Section: Effects Of Maternal Prenatal Stress On the Offspringmentioning

confidence: 99%

The impact of psychological distress during pregnancy on the developing fetus: biological mechanisms and the potential benefits of mindfulness interventions

Isgut

Smith

Reimann

et al. 2017

Journal of Perinatal Medicine

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Abstract:The in utero environment plays an essential role in shaping future growth and development. Psychological distress during pregnancy has been shown to perturb the delicate physiological milieu of pregnancy, and has been associated with negative repercussions in the offspring, including adverse birth outcomes, long-term defects in cognitive development, behavioral problems during childhood and high baseline levels of stress-related hormones. Fetal epigenetic programming, involving epigenetic processes, may help explain the link between maternal prenatal stress and its negative effects on the child. Given the potential long-term effects of early-life stress on a child's health, it is crucial to minimize maternal distress during pregnancy. A number of recent studies have examined the usefulness of mindfulness-based programs to reduce prenatal psychological stress and improve maternal psychological health, and these are reviewed here. Overall, the findings are promising, but more research is needed with large studies using randomized controlled study designs. It remains unclear whether or not such interventions could also improve child health outcomes, and whether these changes are modulated at the epigenetic level during fetal development. Further studies in this area are needed.

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Neonatal Outcomes in Women With Untreated Antenatal Depression Compared With Women Without Depression

Cited by 378 publications

References 45 publications

Sintomas depressivos na gestação e fatores associados: estudo longitudinal

Sintomas depressivos na gestação e fatores associados: estudo longitudinal

Perinatal selective serotonin reuptake inhibitor (SSRI) effects on body weight at birth and beyond: A review of animal and human studies

The impact of psychological distress during pregnancy on the developing fetus: biological mechanisms and the potential benefits of mindfulness interventions

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