Perinatal selective serotonin reuptake inhibitor (SSRI) effects on body weight at birth and beyond: A review of animal and human studies

Hutchison, Sarah M; Mâsse, Louise C.; Pawluski, Jodi L.; Oberlander, Tim F.

doi:10.1016/j.reprotox.2018.02.004

Cited by 26 publications

(13 citation statements)

References 154 publications

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“…Indeed, increased mortality and lower birth weight after FLX or paroxetine exposure in pups is not uncommon (Voorhees, 1994; Fornaro et al, 2007; Cagiano et al, 2008; Van den Hove et al, 2008; Müller et al, 2013). Both human and preclinical studies show an association between SSRIs and lower birth weight (reviewed in Hutchison et al, 2018). By blocking the SERT, FLX can acutely increase serotonin plasma levels resulting in restricted umbilical artery blood flow due to serotonin’s vasoconstrictive properties (Taniguchi et al, 1994).…”

Section: Discussionmentioning

confidence: 99%

Subjecting Dams to Early Life Stress and Perinatal Fluoxetine Treatment Differentially Alters Social Behavior in Young and Adult Rat Offspring

et al. 2019

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Recently, the putative association between selective serotonin reuptake inhibitor (SSRI) exposure during pregnancy and the development of social disorders in children has gained increased attention. However, clinical studies struggle with the confounding effects of maternal depression typically co-occurring with antidepressant treatment. Furthermore, preclinical studies using an animal model of maternal depression to study effects of perinatal SSRI exposure on offspring social behavior are limited. Therefore, the aim of this study was to investigate effects of perinatal fluoxetine exposure on juvenile and adult social behavior in male and female rat offspring, using an animal model of maternal vulnerability. We exposed heterozygous serotonin transporter (SERT) deficient female rats to early life maternal separation stress, and used this as a model for maternal vulnerability. Control and early life stressed heterozygous serotonin transporter knockout (SERT) dams were treated with the SSRI fluoxetine or vehicle throughout gestation and lactation. Subsequently, both male and female wildtype (SERT+/+) and heterozygous (SERT+/-) rat offspring were tested for pup ultrasonic vocalizations (USVs), juvenile social play behavior and adult social interaction. Fluoxetine treatment of the dams resulted in a reduced total USV duration in pups at postnatal day 6, especially in SERT+/+ males. Perinatal fluoxetine exposure lowered social play behavior in male offspring from both control and early life stressed dams. However, in females a fluoxetine-induced reduction in juvenile play behavior was only present in offspring from control dams. Offspring genotype did not affect juvenile play behavior. Despite fluoxetine-induced behavioral effects at juvenile age, fluoxetine reduced male adult social behavior in offspring from control dams only. Effects of fluoxetine on female adult social behavior were virtually absent. Interestingly, early life stress in dams increased adult social exploration in vehicle exposed SERT+/+ female offspring and total social behavior in fluoxetine exposed adult SERT+/- male offspring. Furthermore, SERT+/- males appeared less social during adulthood compared to SERT+/+ males. Overall, the present study shows that chronic blockade of the serotonin transporter by fluoxetine during early development has a considerable impact on pup USVs, juvenile social play behavior in both male and female offspring, and to a lesser extent on male social interaction in adulthood.

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Section: Discussionmentioning

confidence: 99%

Subjecting Dams to Early Life Stress and Perinatal Fluoxetine Treatment Differentially Alters Social Behavior in Young and Adult Rat Offspring

et al. 2019

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“…SSRIs are prescribed to treat the growing number of women diagnosed with peripartum mood and anxiety disorders despite the fact that we know very little about how these medications affect the maternal brain (Drury et al, 2016;Gavin et al, 2005;Moses-Kolko et al, 2014;Pawluski et al, 2019a;Pawluski et al, 2019b;Pawluski et al, 2017). SSRIs and their metabolites cross the placenta (Angelotta and Wisner, 2017;Oberlander et al, 2009;Pohland et al, 1989) raising questions about the safety for the fetus of using these medications (Field, 2010;Gemmel et al, 2018a;Glover and Clinton, 2016;Homberg et al, 2010;Hutchison et al, 2018). Much research has focused on how these medications may affect the fetus and developing child but much less is known about how these medications affect the mother (Lonstein, 2018;Pawluski and Dickens, 2019;Pawluski et al, 2019b).…”

Section: Introductionmentioning

confidence: 99%

Effect of sertraline on central serotonin and hippocampal plasticity in pregnant and non-pregnant rats

et al. 2020

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“…Although the reason for the sex difference observed in the current study and in Nielsen et al (2019) is unknown, other effects of SSRIs, such as anxiolysis, have been shown to be sex-dependent in Endler guppy (Poecilia wingei) after exposure to citalopram (Olsén et al 2014), the Eastern mosquitofish (Gambusia holbrooki) where fluoxetine provokes a sex-divergent response in freezing behaviour (Martin et al 2017), and in rodents (Fernández-Guasti et al 2017;Lebrón-Milad et al 2013). In studies with rodents, there are mixed effects of SSRI exposure on sex difference in feeding and changes in weight (Currie et al 2004;Hutchison et al 2018).…”

Section: Discussionmentioning

confidence: 55%

Divergent Response to the SSRI Citalopram in Male and Female Three-Spine Sticklebacks (Gasterosteus aculeatus)

Kellner

Olsén

2020

Arch Environ Contam Toxicol

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Selective serotonin reuptake inhibitors (SSRIs) are psychotropic pharmaceuticals used as antidepressants. SSRIs are commonly found in surface waters in populated areas across the globe. They exert their effect by blocking the serotonin re-uptake transporter in the presynaptic nerve ending. The present study examined whether behavioural effects to exposure to SSRI citalopram depend on personality and sex in the stickleback (Gasterosteus aculeatus). Three aspects of stickleback behaviour are examined: feeding behaviour, aggression, and boldness. We exposed sticklebacks to 350–380 ng/l citalopram for 3 weeks. Feeding and aggressive behaviour were recorded before and after exposure, whereas scototaxis behaviour was tested after exposure. The results show treatment effects in feeding and aggressive behaviour. Feeding is suppressed only in the male group (χ2 = 20.4, P < 0.001) but not in the females (χ2 = 0.91, P = 0.339). Aggressive behaviour was significantly affected by treatment (χ2 = 161.9, P < 0.001), sex (χ2 = 86.3, P < 0.001), and baseline value (χ2 = 58.8, P < 0.001). Aggressiveness was suppressed by citalopram treatment. In addition, the fish showed no change in aggression and feeding behaviour over time regardless of sex and treatment, which indicate personality traits. Only females are affected by treatment in the scototaxis test. The exposed females spent significantly (χ2 = 5.02, P = 0.050) less time in the white zone than the female controls.

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Perinatal selective serotonin reuptake inhibitor (SSRI) effects on body weight at birth and beyond: A review of animal and human studies

Cited by 26 publications

References 154 publications

Subjecting Dams to Early Life Stress and Perinatal Fluoxetine Treatment Differentially Alters Social Behavior in Young and Adult Rat Offspring

Subjecting Dams to Early Life Stress and Perinatal Fluoxetine Treatment Differentially Alters Social Behavior in Young and Adult Rat Offspring

Effect of sertraline on central serotonin and hippocampal plasticity in pregnant and non-pregnant rats

Divergent Response to the SSRI Citalopram in Male and Female Three-Spine Sticklebacks (Gasterosteus aculeatus)

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