Myocardial ischemic preconditioning upregulated protein 1(Mipu1):zinc finger protein 667 - a multifunctional KRAB/C2H2 zinc finger protein

Abstract

Myocardial ischemic preconditioning upregulated protein 1 (Mipu1) is a newly discovered upregulated gene produced in rats during the myocardial ischemic preconditioning process. Mipu1 cDNA contains a 1824-base pair open reading frame and encodes a 608 amino acid protein with an N-terminal Krüppel-associated box (KRAB) domain and classical zinc finger C2H2 motifs in the C-terminus. Mipu1 protein is located in the cell nucleus. Recent studies found that Mipu1 has a protective effect on the ischemia-reperfusion injury of heart, brain, and other organs. As a nuclear factor, Mipu1 may perform its protective function through directly transcribing and repressing the expression of proapoptotic genes to repress cell apoptosis. In addition, Mipu1 also plays an important role in regulating the gene expression of downstream inflammatory mediators by inhibiting the activation of activator protein-1 and serum response element.

Regulation of microvascularization in heart failure - an endothelial cell, non-coding RNAs and exosome liaison

“…While recent findings report a decrease in circulating levels of miR-126 after myocardial infarction, miR-126 expression profiles can also be correlated to cardiac function indexes, strongly supporting the contribution of miR-126 to regulation of proper cardiac function ( Fig. 1 ) [81] , [84] .…”

“…It directly inhibits sprout-related, EVH1 domain, containing 1 (SPRED1), an inhibitor of the extracellular regulated MAP kinase (ERK), to prevent its anti-angiogenic action. miR-126 is also a potent anti-apoptotic factor through regulation of the PI3K/Akt [81] , [82] , [83] . While recent findings report a decrease in circulating levels of miR-126 after myocardial infarction, miR-126 expression profiles can also be correlated to cardiac function indexes, strongly supporting the contribution of miR-126 to regulation of proper cardiac function ( Fig.…”

Taurine Increases Zinc Preconditioning‐Induced Prevention of Nitrosative Stress, Metabolic Alterations, and Motor Deficits in Young Rats following Intrauterine Ischemia

“…Zinc finger proteins could mediate the zinc-induced protection against ischemic damage at several levels. For instance, ZNF667 or Mipu1 regulates gene expression [ 68 – 70 ] activated by inflammatory mediators [ 71 ] and oxidative stress [ 72 , 73 ]. Through this mechanism, zinc inhibits Bax [ 70 ] and Fas [ 72 ] expression, thus preventing apoptosis.…”

Molecular Mechanisms of Ischemic Preconditioning with Cardiovascular Aging in Elderly Patients with Arterial Hypertension

“…Myocardial ischemic preconditioning upregulated protein 1 (Mipu1) is a newly discovered upregulated gene produced in rats during the myocardial ischemic preconditioning process. Mipu1 is a nuclear factor with a variety of biological functions, such as participation in the process of myocardial ischemic preconditioning, protection of the myocardium from ischemic disease, and inflammation [24]. Analysis of the function of Mipu1, as well as vascular endothelial growth factor-A (an important neuroprotectant) and ACE (a central component of the renin-angiotensin system) in CVD is beneficial because it may provide new ideas for prevention of cardiovascular aging.…”