Myocardial ischemic preconditioning upregulated protein 1 (Mipu1) is
a newly discovered upregulated gene produced in rats during the myocardial ischemic
preconditioning process. Mipu1 cDNA contains a 1824-base pair open
reading frame and encodes a 608 amino acid protein with an N-terminal
Krüppel-associated box (KRAB) domain and classical zinc finger
C2H2 motifs in the C-terminus. Mipu1
protein is located in the cell nucleus. Recent studies found that
Mipu1 has a protective effect on the ischemia-reperfusion injury
of heart, brain, and other organs. As a nuclear factor, Mipu1 may
perform its protective function through directly transcribing and repressing the
expression of proapoptotic genes to repress cell apoptosis. In addition,
Mipu1 also plays an important role in regulating the gene
expression of downstream inflammatory mediators by inhibiting the activation of
activator protein-1 and serum response element.
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