Multifunctional Nanotherapeutics for Photothermal Combination Therapy of Cancer

Abstract

Recently, photothermal therapy (PTT) has demonstrated excellent results in the treatment of preclinical cancer models and thus attracted intensive interests from the research fields of material science, biochemistry, oncology, and pharmacy. Also, its combination with other cancer therapies shows great promise for clinical application: PTT is able to make up for the drawbacks of others and improve the prognosis through various synergistic effects. In these combination therapies, design of nanoscale multifunctional therapeutics is key to achieve enhanced or even synergistic therapeutic effect. Herein, the recent progress is summarized in the development of strategies involving combination of PTT with other cancer therapies, conventional or emerging, with increased efficacy. The highlight lies in integrating various functional units to form multifunctional nanomaterials that play the role of photothermal agents as well as other therapeutics in a combination therapy and the design of an effective targeted delivery system for them. Smart combination of therapies will undoubtedly improve the therapeutic efficacy and make a contribution to the advancement in fighting cancer.

Tailored Synthesis of PEGylated Bismuth Nanoparticles for X-ray Computed Tomography and Photothermal Therapy: One-Pot, Targeted Pyrolysis, and Self-Promotion

“…The bismuth-based medicines, such as bismuth subcitrate, have been used for the treatment of gastrointestinal diseases in clinics for more than three centuries . Second, Bi is a heavy metal element ( Z = 83) and possesses good X-ray attenuation properties. − Thus, it can be applied as an efficient contrast agent for computed tomography (CT). Third, Bi-based nanoparticles have a strong light absorbance in near-infrared area for photothermal therapy (PTT). , Fourth, compared with Au that has been widely applied in PTT, Bi is nearly 2000-fold cheaper per mole and 2 times terrestrially more abundant, making Bi nanoparticles economically attractive for biomedical use …”

Inorganic Nanomaterials for Photothermal‐Based Cancer Theranostics

“…[213] Unfortunately these nucleic acids can be inactivated by specific enzymes in the bloodstream, resulting in the low cellular uptake of free nucleic acids. [214] To overcome this problem, researchers have , 5 min) after 24 h. Reproduced with permission. [142] Copyright 2020, Royal Society of Chemistry.…”

Recent progress in metal–organic framework-based sonosensitizers for sonodynamic tumor therapy

“…In recent decades, photodynamic/photothermal therapy has been used to treat superficial tumors in clinical trials with good therapeutic results. 9 However, it should be noted that the penetration depth of light (∼1 cm) is seriously limited due to the high scattering effects of biological tissues, thus restricting photodynamic/photothermal therapy in treating deep-seated tumors in clinical applications.…”