Recent progress in metal–organic framework-based sonosensitizers for sonodynamic tumor therapy

Abstract

In recent years, sonodynamic therapy (SDT) has emerged as a promising approach in biomedicine, due to its low toxicity, non-invasiveness, and deep tissue penetration for effective treatment of deep tumors....

Recent advances in sonodynamic therapy strategies for pancreatic cancer

“…In the case of inorganic photosensitizers, ultraviolet excitation results in the generation of electron–hole pairs in the material. These pairs then react with surrounding oxygen or water molecules, generating a series of ROS, including hydroxyl radicals (Q. Jiang, Gao, et al, 2023). Given this context, SDT presents several advantages in the treatment of cancer.…”

“…These pairs then react with surrounding oxygen or water molecules, generating a series of ROS, including hydroxyl radicals (Q. Jiang, Gao, et al, 2023). Given this context, SDT presents several advantages in the treatment of cancer.…”

A novel cartilage-targeting MOF-HMME-RGD sonosensitizer combined with sonodynamic therapy to enhance chondrogenesis and cartilage regeneration

“…The formation of coordination bonds is facilitated by the coordination of metal ions or clusters with functional organic ligands, resulting in the creation of these frameworks ( Wen et al, 2023 ). MOFs have attracted extensive research interest and have been widely used in drug delivery due to the unique features of facile synthesis, diverse compositions, adjustable porosity, high surface areas, easy surface functionalization, good dispersibility, high loading capacities, and tunable biocompatibility ( Jiang et al, 2023 ). In our previous studies, we developed pH-responsive MOFs modified by hyaluronic acid (HA) loaded with anti-inflammatory protocatechuic acid (PCA) for osteoarthritis therapy ( Xiong et al, 2020 ) and zinc-based MOFs with antibacterial and anti-inflammatory properties for promoting wound healing ( Chen et al, 2022 ).…”

Mn(ii)–hemoporfin-based metal–organic frameworks as a theranostic nanoplatform for MRI-guided sonodynamic therapy

“…, noble metal nanoparticles, transition metal oxides, or semiconductors), 14–16 and organic–inorganic hybrid nanomaterials ( e.g. , metalloporphyrin complex, mesoporous nanoparticles, or metal–organic frameworks) 17–19 have been developed for SDT. However, the therapeutic efficacy of SDT cannot meet clinical needs due to the heterogeneity of tumors between patients, 20 rendering it unsuitable for all individuals.…”