Inorganic Nanomaterials for Photothermal‐Based Cancer Theranostics

Wen, Huang; Tamarov, Konstantin; Happonen, Emilia; Lehto, Vesa‐Pekka

doi:10.1002/adtp.202000207

Cited by 15 publications

(11 citation statements)

References 388 publications

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“…Materials with good photothermal properties include gold nanorods, nonstoichiometric metal chalcogenides, carbon materials, etc. [651][652][653] Type III: photothermal cocatalysis. The photoreaction mechanism and thermal reaction mechanism intertwine or form a cascade of steps to drive the reaction, leading to a synergistic effect of photochemical and thermochemical pathways, as opposed to a simple addition of the two pathways.…”

Section: Review Articlementioning

confidence: 99%

Metalated covalent organic frameworks: from synthetic strategies to diverse applications

2022

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Section: Review Articlementioning

confidence: 99%

Metalated covalent organic frameworks: from synthetic strategies to diverse applications

2022

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“…The worldwide statistics of cancer-associated mortalities and morbidities continue to increase despite the advances in surgery, chemotherapy (CTX), immunotherapy, and radiotherapy (RT) [ 1 , 2 ]. The increase in cancer-related deaths is possibly due to the therapy-associated side effects owing to the lack of specificity and selectivity.…”

Section: Introductionmentioning

confidence: 99%

Next-generation engineered nanogold for multimodal cancer therapy and imaging: a clinical perspectives

2022

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Cancer is one of the significant threats to human life. Although various latest technologies are currently available to treat cancer, it still accounts for millions of death each year worldwide. Thus, creating a need for more developed and novel technologies to combat this deadly condition. Nanoparticles-based cancer therapeutics have offered a promising approach to treat cancer effectively while minimizing adverse events. Among various nanoparticles, nanogold (AuNPs) are biocompatible and have proved their efficiency in treating cancer because they can reach tumors via enhanced permeability and retention effect. The size and shape of the AuNPs are responsible for their diverse therapeutic behavior. Thus, to modulate their therapeutic values, the AuNPs can be synthesized in various shapes, such as spheres, cages, flowers, shells, prisms, rods, clusters, etc. Also, attaching AuNPs with single or multiple targeting agents can facilitate the active targeting of AuNPs to the tumor tissue. The AuNPs have been much explored for photothermal therapy (PTT) to treat cancer. In addition to PTT, AuNPs-based nanoplatforms have been investigated for combinational multimodal therapies in the last few years, including photodynamic therapy, chemotherapy, radiotherapy, immunotherapy, etc., to ablate cancer cells. Thus, the present review focuses on the recent advancements in the functionalization of AuNPs-based nanoconstructs for cancer imaging and therapy using combinatorial multimodal approaches to treat various cancers. Graphical Abstract

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“…Reliability of conventional treatment strategies to treat cancer patients is losing pace every day, hence, designing a safe and cost‐effective treatment strategy has become a priority to reduce disease allied deaths globally (Kelak et al, 2018). To overcome the above‐highlighted hurdles, numerous surface engineered tinny sized “nanomedicines” such as plasmonic gold nanoparticles, polymeric nanospheres, graphene oxide sheets, porous silica particles, gold‐silica hybrid structures, drug conjugated self‐assemblies, and so forth have been proposed for cancer imaging and therapeutic applications (Chauhan et al, 2019; Gonçalves et al, 2020; Lerra et al, 2019; Li Volsi et al, 2017; Mehta et al, 2021; Ren et al, 2020; Selvaraj et al, 2018; Y. Wang, Wang, et al, 2018; Wen et al, 2021). However, sophisticated synthesis and surface engineering, low cargo capacity, slow biodegradation, poor biocompatibility, lack of site‐selective drug delivery response, easy absorption of protein molecules on their surface during blood circulation, major accumulation in liver and spleen, low penetration, and retention ability in tumor environment are critical obstacles of these nanostructures (Bailly et al, 2019; Cai & Chen, 2019; Chinen et al, 2017; Farjadian et al, 2019; Kramer et al, 2017; J.‐Y.…”

Section: Introductionmentioning

confidence: 99%

Bioinspired soft nanovesicles for site‐selective cancer imaging and targeted therapies

Prasad

Conde

2022

WIREs Nanomed Nanobiotechnol

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Cell-to-cell communication within the heterogeneous solid tumor environment plays a significant role in the uncontrolled metastasis of cancer. To inhibit the metastasis and growth of cancer cells, various chemically designed and biologically derived nanosized biomaterials have been applied for targeted cancer therapeutics applications. Over the years, bioinspired soft nanovesicles have gained tremendous attention for targeted cancer therapeutics due to their easy binding with tumor microenvironment, natural targeting ability, bioresponsive nature, better biocompatibility, high cargo capacity for multiple therapeutics agents, and long circulation time. These cell-derived nanovesicles guard their loaded cargo molecules from immune clearance and make them site-selective to cancer cells due to their natural binding and delivery abilities. Furthermore, bioinspired soft nanovesicles prevent cell-to-cell communication and secretion of cancer cell markers by delivering the therapeutics agents predominantly. Cell-derived vesicles, namely, exosomes, extracellular vesicles, and so forth have been recognized as versatile carriers for therapeutic biomolecules. However, low product yield, poor reproducibility, and uncontrolled particle size distribution have remained as major challenges of these soft nanovesicles. Furthermore, the surface biomarkers and molecular contents of these vesicles change with respect to the stage of disease and types. Here in this review, we have discussed numerous examples of bioinspired soft vesicles for targeted imaging and cancer therapeutic applications with their advantages and limitations. Importance of bioengineered soft nanovesicles for localized therapies with their clinical relevance has also been addressed in this article. Overall, cell-derived nanovesicles could be considered as clinically relevant platforms for cancer therapeutics.

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Inorganic Nanomaterials for Photothermal‐Based Cancer Theranostics

Cited by 15 publications

References 388 publications

Metalated covalent organic frameworks: from synthetic strategies to diverse applications

Metalated covalent organic frameworks: from synthetic strategies to diverse applications

Next-generation engineered nanogold for multimodal cancer therapy and imaging: a clinical perspectives

Bioinspired soft nanovesicles for site‐selective cancer imaging and targeted therapies

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