Monitoring of N-nitrosodiethanolamine in cosmetic products by ion-pair complex liquid chromatography and identification with negative ion electrospray ionization mass spectrometry

Ghassempour, Alireza; Abbaci, Monireh; Talebpour, Zahra; Spengler, Bernhard; Römpp, Andreas

doi:10.1016/j.chroma.2007.12.045

Cited by 25 publications

(16 citation statements)

References 21 publications

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“…Thus extraction method plays the main role for reliable measurements of trace concentration levels of NAs. Typically, sorptive extraction methods including SPE with different stationary phases and microextraction methods such as SPME and stir bar sorptive extraction (SBSE) have been described as appropriate methods for extraction and preconcentration of NAs.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of a method for the simultaneous quantification of N‐nitrosamines in water samples based on stir bar sorptive extraction combined with high‐performance liquid chromatography and diode array detection

Talebpour

Rostami

Rezadoost

2015

J of Separation Science

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A simple, sensitive, and reliable procedure based on stir bar sorptive extraction coupled with high-performance liquid chromatography was applied to simultaneously extract and determine three semipolar nitrosamines including N-nitrosodibutylamine, N-nitrosodiphenylamine, and N-nitrosodicyclohexylamine. To achieve the optimum conditions, the effective parameters on the extraction efficiency including desorption solvent and time, ionic strength of sample, extraction time, and sample volume were systematically investigated. The optimized extraction procedure was carried out by stir bars coated with polydimethylsiloxane. Under optimum extraction conditions, the performance of the proposed method was studied. The linear dynamic range was obtained in the range of 0.95-1000 ng/mL (r = 0.9995), 0.26-1000 ng/mL (r = 0.9988) and both 0.32-100 ng/mL (r = 0.9999) and 100-1000 ng/mL (r = 0.9998) with limits of detection of 0.28, 0.08, and 0.09 ng/mL for N-nitrosodibutylamine, N-nitrosodiphenylamine, and N-nitrosodicyclohexylamine, respectively. The average recoveries were obtained >81%, and the reproducibility of the proposed method presented as intra- and interday precision were also found with a relative standard deviation <6%. Finally, the proposed method was successfully applied to the determination of trace amounts of selected nitrosamines in various water and wastewater samples and the obtained results were confirmed using mass spectrometry.

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Section: Introductionmentioning

confidence: 99%

Evaluation of a method for the simultaneous quantification of N‐nitrosamines in water samples based on stir bar sorptive extraction combined with high‐performance liquid chromatography and diode array detection

Talebpour

Rostami

Rezadoost

2015

J of Separation Science

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“…Exogenous N-nitroso compounds exist in food (3), tabacco smoke (4), workplace conditions (5,6), and cosmetics (7,8). In addition, N-nitroso compounds formed endogenously mainly in the stomach and intestine (9,10) or infected site (11,12).…”

Section: Introductionmentioning

confidence: 99%

Antimutagenicity Screening of Extracts from Medicinal and Edible Plants against N-Methyl-N-nitrosourea by the Ames Assay

Tatsuzaki¹,

Yang²,

Kojo

et al. 2014

Genes and Environment

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N-Nitroso compounds are suspected to be causative agents for human cancer. N-Methyl-N-nitrosourea (MNU) is a typical direct acting mutagen with alkylation activity of DNA, and has been reported to be formed in vivo. Therefore, it is important for cancer chemoprevention toˆnd some compounds to inhibit mutagenicity induced by MNU. The inhibitory eŠect of plant extracts against the mutagenicity of MNU was evaluated using the Ames assay with Salmonella typhimurium TA1535. Among 43 extracts derived from medicinal and edible plant assayed, Glycyrrhiza aspera ethanolic extract, Glycine max extract with 40% iso‰avone aglycone (ISOMAX AG40) and Zingiber o‹cinale ethanolic extract at the range 0.01-1.0 mg/plate inhibited MNU-induced mutagenicity in S. typhimurium TA1535. No cytotoxicity of the three extracts were observed in Salmonella typhimuirum TA1535, indicating that inhibition of MNU-induced mutagenicity was apparently due to the antimutagenic potency of Glycyrrhiza aspera ethanolic extract, ISOMAX AG40 and Zingiber o‹cinale ethanolic extract. Therefore, the results of relative mutagenicity showed that Glycyrrhiza aspera ethanolic extract and ISOMAX AG40 decreased the mutagenic eŠects to 5.4% and 2.6%, respectively, whereas Zingiber o‹cinale ethanolic extract decreased it to 45%.

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“…Humans are exposed to N-nitroso compounds exogenously through sources such as food, tobacco smoke, air, water and cosmetics (1)(2)(3)(4)(5)(6). In addition, Nnitroso compounds have been reported to be formed endogenously mainly in the stomach and the bowel or in an infection site (7)(8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Antimutagenic Effects of Aqueous Extracts from Herbal Medicines against N-Alkyl-N-nitrosoureas-induced Mutagenicity Using the umu Test

Inami

Takada

Itoh

et al. 2014

Genes and Environment

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Monitoring of N-nitrosodiethanolamine in cosmetic products by ion-pair complex liquid chromatography and identification with negative ion electrospray ionization mass spectrometry

Cited by 25 publications

References 21 publications

Evaluation of a method for the simultaneous quantification of N‐nitrosamines in water samples based on stir bar sorptive extraction combined with high‐performance liquid chromatography and diode array detection

Evaluation of a method for the simultaneous quantification of N‐nitrosamines in water samples based on stir bar sorptive extraction combined with high‐performance liquid chromatography and diode array detection

Antimutagenicity Screening of Extracts from Medicinal and Edible Plants against N-Methyl-N-nitrosourea by the Ames Assay

Assessment of the Antimutagenic Effects of Aqueous Extracts from Herbal Medicines against N-Alkyl-N-nitrosoureas-induced Mutagenicity Using the umu Test

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