Molecular mechanisms underlying Ca<sup>2+</sup>-mediated motility of human pancreatic duct cells

Dong, Hui; Shim, Ki Nam; Li, Jenny M. J.; Estrema, Christine L.; Ornelas, Tiffany A.; Nguyen, Flang; Liu, Shanglei; Ramamoorthy, Sonia; Ho, Samuel; Carethers, John M.; Chow, Jennifer

doi:10.1152/ajpcell.00242.2010

Cited by 68 publications

(64 citation statements)

References 61 publications

(58 reference statements)

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“…Several genes in TRPV channel have been detected to be up-regulated in prostate, colon, and breast cancer cells [40-42]. Particularly, TRPV5 and TRPV6 genes exhibit unusually high levels of single nucleotide polymorphisms (SNPs) in African populations as compared to other populations [41].…”

Section: Resultsmentioning

confidence: 99%

Pathway-gene identification for pancreatic cancer survival via doubly regularized Cox regression

Gong

Clarke

2014

BMC Systems Biology

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BackgroundRecent global genomic analyses identified 69 gene sets and 12 core signaling pathways genetically altered in pancreatic cancer, which is a highly malignant disease. A comprehensive understanding of the genetic signatures and signaling pathways that are directly correlated to pancreatic cancer survival will help cancer researchers to develop effective multi-gene targeted, personalized therapies for the pancreatic cancer patients at different stages. A previous work that applied a LASSO penalized regression method, which only considered individual genetic effects, identified 12 genes associated with pancreatic cancer survival.ResultsIn this work, we integrate pathway information into pancreatic cancer survival analysis. We introduce and apply a doubly regularized Cox regression model to identify both genes and signaling pathways related to pancreatic cancer survival.ConclusionsFour signaling pathways, including Ion transport, immune phagocytosis, TGFβ (spermatogenesis), regulation of DNA-dependent transcription pathways, and 15 genes within the four pathways are identified and verified to be directly correlated to pancreatic cancer survival. Our findings can help cancer researchers design new strategies for the early detection and diagnosis of pancreatic cancer.

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Section: Resultsmentioning

confidence: 99%

Pathway-gene identification for pancreatic cancer survival via doubly regularized Cox regression

Gong

Clarke

2014

BMC Systems Biology

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“…NCX1 has been reported to promote the migration of a diverse group of non-epithelial cells such as endothelial cells, oligodendrocytes, myofibroblasts, microglia, and pancreatic cancer cells (53)(54)(55)(56)(57)(58)(59)(60). Inhibition or knockdown of NCX1 reduced intracellular calcium and prevented migration.…”

Section: Discussionmentioning

confidence: 99%

Sodium-Calcium Exchanger 1 Regulates Epithelial Cell Migration via Calcium-dependent Extracellular Signal-regulated Kinase Signaling

Balasubramaniam

Gopalakrishnapillai

Gangadharan

et al. 2015

Journal of Biological Chemistry

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Background: Sodium-calcium exchanger (NCX1) regulates calcium in renal epithelial cells. Results: Na,K-ATPase ␤-subunit regulates NCX1 membrane localization and reduced NCX1 expression or its functional inhibition increases cell migration. Conclusion: NCX1 plays a pivotal role in activation of calcium dependent migration via calmodulin/PI3K/ERK. Significance: Identifying regulators of epithelial cell motility is important in establishing novel therapeutic targets in fibrosis and cancer.

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“…Conversely, a higher level of TRPC1 channel expression has been reported in colorectal carcinoma cells (Sobradillo et al, 2014) as well as in MCF-7 human breast cancer cells (El Hiani et al, 2009) than in normal cells. Accordingly, overexpression of TRPC1 is reported in pancreas cancer and suppression of TRPC1 expression significantly reversed TGF-b-induced motility in BxPc3 pancreatic adenocarcinoma cells (Dong et al, 2010).…”

Section: Trp Expression In Cancer Through Hts Datasetsmentioning

confidence: 95%

Human transient receptor potential (TRP) channel expression profiling in carcinogenesis

Bernardini¹,

Fiorio²,

Prevarskaya³

et al. 2015

Int. J. Dev. Biol.

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Despite the intensive research of the last three decades into Transient Receptor Potential (TRP) cation channels, no precise and complete profiling of these channels is yet available regarding their involvement in physiopathology and carcinogenesis in particular. TRP channel activity is crucial for all the essential hallmarks of carcinogenesis such as proliferation, apoptosis, migration and angiogenesis, which is the reason why these channels have been proposed not only as clinical markers, but also as promising targets for anti-cancer therapy. However, in the majority of studies, each channel has been considered as a separate molecular entity and studied independently from the other TRPs, while a complete "transportome" of the specific stages of carcinogenesis is required for the effective use of these targets. This review focuses on the partial TRP expression profiles found in the literature and the means by which a full TRP signature could be achieved.

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Molecular mechanisms underlying Ca²⁺-mediated motility of human pancreatic duct cells

Cited by 68 publications

References 61 publications

Pathway-gene identification for pancreatic cancer survival via doubly regularized Cox regression

Pathway-gene identification for pancreatic cancer survival via doubly regularized Cox regression

Sodium-Calcium Exchanger 1 Regulates Epithelial Cell Migration via Calcium-dependent Extracellular Signal-regulated Kinase Signaling

Human transient receptor potential (TRP) channel expression profiling in carcinogenesis

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Molecular mechanisms underlying Ca2+-mediated motility of human pancreatic duct cells

Cited by 68 publications

References 61 publications

Pathway-gene identification for pancreatic cancer survival via doubly regularized Cox regression

Pathway-gene identification for pancreatic cancer survival via doubly regularized Cox regression

Sodium-Calcium Exchanger 1 Regulates Epithelial Cell Migration via Calcium-dependent Extracellular Signal-regulated Kinase Signaling

Human transient receptor potential (TRP) channel expression profiling in carcinogenesis

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Molecular mechanisms underlying Ca²⁺-mediated motility of human pancreatic duct cells