Sona Lakshme Balasubramaniam scite author profile

Background: Sodium-calcium exchanger (NCX1) regulates calcium in renal epithelial cells. Results: Na,K-ATPase ␤-subunit regulates NCX1 membrane localization and reduced NCX1 expression or its functional inhibition increases cell migration. Conclusion: NCX1 plays a pivotal role in activation of calcium dependent migration via calmodulin/PI3K/ERK. Significance: Identifying regulators of epithelial cell motility is important in establishing novel therapeutic targets in fibrosis and cancer.

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Ion dependence of Na-K-ATPase-mediated epithelial cell adhesion and migration

Balasubramaniam

Gopalakrishnapillai

Barwe

2015

American Journal of Physiology-Cell Physiology

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Sona Lakshme Balasubramaniam

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Sodium-Calcium Exchanger 1 Regulates Epithelial Cell Migration via Calcium-dependent Extracellular Signal-regulated Kinase Signaling

Ion dependence of Na-K-ATPase-mediated epithelial cell adhesion and migration

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