TCAF1 and TCAF2 bind to TRPM8 and promote its cell surface trafficking but differentially regulate its gating properties, leading to opposing effects on prostate cancer cell migration.
Genova et al. describe a novel non-channel function for the endogenous TRPM8 as a negative regulator of Rap1 GTPase. TRPM8 retains Rap1GDP intracellularly thus resulting in altered behavior of vascular endothelial cell adhesion and migration.
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