Mimosa (Mimosa caesalpiniifolia)prevents oxidative DNA damage induced by cadmium exposure in Wistar rats

Abstract

The Mimosa (Mimosa caesalpiniifolia) is a plant native from South America; it is used in the traditional medicine systems for treating bacterial, fungal, parasitic and inflammatory conditions. The aim of this study was to evaluate the antigenotoxic and antioxidant activities induced by mimosa (M. caesalpiniifolia) in multiple rodent organs subjected to intoxication with cadmium chloride. A total of 40 Wistar rats (8 weeks old, 250 g) were distributed into eight groups (n = 5), as follows: Control group (non-treated group, CTRL); Cadmium exposed group (Cd); cadmium exposure and treated with extract at 62.5 mg/kg/day; cadmium exposure and treated with extract at 125 mg/kg/day; cadmium exposure and treated with extract at 250 mg/kg/day; cadmium exposure and treated with ethyl acetate fraction at 62.5 mg/kg/day. For evaluating the toxicogenetic potential of mimosa, two groups were included in the study being treated with extract at 250 mg/kg/day and acetate fraction of mimosa at 62 mg/kg/day, only. Extract of mimosa at concentrations of 62.5 and 125 mg decreased DNA damage in animals intoxicated with cadmium when compared to cadmium group. In a similar manner, treatment with ethyl acetate fraction of mimosa at 62.5 mg concentration in animals previously exposed to cadmium reduced genetic damage in peripheral blood cells. In a similar manner, the treatment with ethyl acetate fraction reduced DNA damage in liver cells. Oxidative DNA damage was reduced to animals exposed to cadmium and treated with 125 mg of extract as well as those intoxicated to cadmium and treated with 62.5 of acetate fraction of mimosa. Taken together, our results indicate that mimosa prevents genotoxicity induced by cadmium exposure in liver and peripheral blood cells of rats as a result of antioxidant activity.

The Anti-Inflammatory Potential of Mimosa caesalpiniifolia Following Experimental Colitis: Role of COX-2 and TNF-Alpha Expression

“…The chemical characterization of M. caesalpiniifolia was performed in a previous study conducted by our research group [13]. The major components of interest with m/z between 300 and 500 were identified: catechin and caffeoyl-D-glucose, detected as the deprotonated mass of m/z 289 and 341, respectively in the alcoholic extract.…”

“…All animals were euthanized 8 days after colitis induction. The doses were chosen in a previous study conducted by our research group [13]. M. caesalpiniifolia was diluted in filtered water and administrated by gavage in a final volume of 1 mL every day in the morning.…”

“…The 7 days period after induction was based on previous studies conducted by our research group using experimental colitis induced by TNBS and nutraceuticals rich in polyphenols [12,14]. Taking into consideration the fact that some authors have postulated that polyphenols are also able to prevent rat colon carcinogenesis when administrating before the chemical induction, we decide to administrate M. caesalpiniifolia 7 days before inducing experimental colitis in order to evaluate if M. caesalpiniifolia exerts some preventive action against experimental colitis as well [13]. The experimental design is presented in ▶Fig.…”

Antimicrobial activity of Mimosa caesalpiniifolia Benth and its interaction with antibiotics against Staphylococcus aureus strains overexpressing efflux pump genes

“…Ethanoic extract from the leaves of M. caesalpiniifolia and its ethyl acetate fractions exhibited antioxidant activity and prevented oxidative DNA damage in Wistar rats (Silva et al . ).…”

“…Ethanoic extract from inflorescences of M. caesalpiniifolia showed hypotensive and vasorelaxant effects in normotensive rats (Santos et al 2015). Ethanoic extract from the leaves of M. caesalpiniifolia and its ethyl acetate fractions exhibited antioxidant activity and prevented oxidative DNA damage in Wistar rats (Silva et al 2014).…”