The Anti-Inflammatory Potential of Mimosa caesalpiniifolia Following Experimental Colitis: Role of COX-2 and TNF-Alpha Expression

Silva, Marcelo José Dias; Vilegas, Wagner; Silva, Marcelo Aparecido da; Paiotti, Ana Paula Ribeiro; Pastrelo, Maurício Mercaldi; Ruiz, Pedro Luiz Menin; Moura, Carolina Foot Gomes de; Oshima, Celina Tizuko Fujiyama; Ribeiro, Daniel Araki

doi:10.1055/s-0043-119750

Cited by 7 publications

(9 citation statements)

References 29 publications

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“…Silva et al [ 166 ] reported on the protective action of HyOH extract and EtOAc fraction of M. caesalpiniifolia leaves in adult male Wistar rats suffering from colitis. The HyOH extract (125 and 250 mg/kg) and EtOAc fraction (25 mg/kg) were able to decrease TNF-α immune expression in rats and were found to be effective at lower doses after inducing colitis.…”

Section: Pharmacological Activities Of Genus Mimosamentioning

confidence: 99%

A Comprehensive Review of the Ethnotraditional Uses and Biological and Pharmacological Potential of the Genus Mimosa

Majeed

Ashar

Rasheed

et al. 2021

IJMS

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The Mimosa genus belongs to the Fabaceae family of legumes and consists of about 400 species distributed all over the world. The growth forms of plants belonging to the Mimosa genus range from herbs to trees. Several species of this genus play important roles in folk medicine. In this review, we aimed to present the current knowledge of the ethnogeographical distribution, ethnotraditional uses, nutritional values, pharmaceutical potential, and toxicity of the genus Mimosa to facilitate the exploitation of its therapeutic potential for the treatment of human ailments. The present paper consists of a systematic overview of the scientific literature relating to the genus Mimosa published between 1931 and 2020, which was achieved by consulting various databases (Science Direct, Francis and Taylor, Scopus, Google Scholar, PubMed, SciELO, Web of Science, SciFinder, Wiley, Springer, Google, The Plant Database). More than 160 research articles were included in this review regarding the Mimosa genus. Mimosa species are nutritionally very important and several species are used as feed for different varieties of chickens. Studies regarding their biological potential have shown that species of the Mimosa genus have promising pharmacological properties, including antimicrobial, antioxidant, anticancer, antidiabetic, wound-healing, hypolipidemic, anti-inflammatory, hepatoprotective, antinociceptive, antiepileptic, neuropharmacological, toxicological, antiallergic, antihyperurisemic, larvicidal, antiparasitic, molluscicidal, antimutagenic, genotoxic, teratogenic, antispasmolytic, antiviral, and antivenom activities. The findings regarding the genus Mimosa suggest that this genus could be the future of the medicinal industry for the treatment of various diseases, although in the future more research should be carried out to explore its ethnopharmacological, toxicological, and nutritional attributes.

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Section: Pharmacological Activities Of Genus Mimosamentioning

confidence: 99%

A Comprehensive Review of the Ethnotraditional Uses and Biological and Pharmacological Potential of the Genus Mimosa

Majeed

Ashar

Rasheed

et al. 2021

IJMS

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“…The plant extract exhibits cytotoxic activity against the human breast cancer cell line MCF-7 and reduces oxidative DNA damage produced by cadmium . Furthermore, the plant attenuated lesions of the colon, reduced inflammation, and modulated the expression of COX-2 and TNF-α during chronic colitis caused by TNBS acid (2,4,6-trinitrobenzenesulfonic acid) . Preliminary studies on the antifungal effects of an EtOAc extract from the liquid–liquid extraction of the 70% aqueous ethanolic extract of M. caesalpiniifolia Benth.…”

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confidence: 99%

Bioassay-Guided Isolation of Fungistatic Compounds from Mimosa caesalpiniifolia Leaves

et al. 2019

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A bioassay-guided phytochemical study of a Mimosa caesalpiniifolia leaf extract with antifungal activity permitted the identification of 28 compounds, including the new 6-(β-boivinopyranosyl)apigenin (1), 8-(β-oliopyranosyl)apigenin (2), (E)-6-(2-carboxyethenyl)apigenin (3), (E)-8-(2carboxyethenyl)apigenin (4), and 7,5″-anhydro-6-(α-2,6dideoxy-5-hydroxyarabinohexopyranosyl)apigenin (5). The structures of the new compounds were determined by comprehensive spectroscopic analysis, including 1D and 2D NMR techniques, and by mass spectrometry. Compound 3 showed promising activity and selectivity against Candida krusei (IC 50 44 nM), which exhibits resistance to azoles. The association of the major components 3-β-D-glucopyranosyloxysitosterol (8) and ethyl gallate (10) was synergistic against C. krusei, especially the IC values of compound 10, which were reduced by more than 100-fold.

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“…In summary, the results suggest that M. caesalpiniifolia attenuated colonic lesions as a result of reduced inflammation (16). The main difference between the previous study and the present one, in addition to the model, is that in this case a pre-formulation was made with the vegetal extract of the plant.…”

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confidence: 66%

“…In a previous study, we found that administration of hydroalcoholic extract of M. caesalpiniifolia at a dose of 125 mg/kg after induction of colitis by TNBS was able to mitigate the harmful effects by decreasing colon inflammatory process through negative regulation of TNF-α expression (16,28). With these findings and to evolve in the development of a plantbased medication, the extract of M. caesalpiniifolia was incorporated into the adjuvant Aerosil®, obtaining the pre-formulation at a promising dose of 125 mg/kg.…”

Section: Discussionmentioning

confidence: 96%

“…In a recent study, we found a potential anti-inflammatory effect of the hydroalcoholic extract of M. caesalpiniifolia on trinitrobenzene sulfonic acid (TNBS)-induced colitis in Wistar rats (16). Since the incorporation of plant extracts into pharmaceutical forms can improve their solubility and bioavailability, the present study proposes to evaluate the effects of M. caesalpiniifolia pre-formulation on the intestinal barrier during dextran sulfate sodium (DSS)induced colitis.…”

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confidence: 97%

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Effects of Mimosa caesalpiniifolia pre-formulation on the intestinal barrier during sodium dextran sulfate-induced colitis in Wistar rats

Garnevi-Fávero,

Nascimento-da Silva,

Rodrigues-Ribeiro

et al. 2023

biomedica

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Introduction. Anti-inflammatories, immunosuppressants, and immunobiological are commonly used in the treatment of inflammatory bowel disease. However, some patients do not present an adequate response or lose effective response during the treatment. A recent study found a potential anti-inflammatory effect of the hydroalcoholic extract of Mimosa caesalpiniifolia on trinitrobenzene sulfonic acid-induced colitis in Wistar rats. Objective. To evaluate the effects of M. caesalpiniifolia pre-formulation on the intestinal barrier using dextran sulfate sodium-induced colitis model.Materials and methods. Leaf extracts were prepared in 70% ethanol and dried with a Buchi B19 Mini-spray dryer using 20% Aerosil® solution. Thirty-two male Wistar ratswere randomized into four groups: basal control, untreated colitis, pre-formulation control (125 mg/kg/day), and colitis treated with pre-formulation (125 mg/kg/day). Clinical activity index was recorded daily and all rats were euthanized on the ninth day. Colon fragments were fixed and processed for histological and ultrastructural analyses. Stool samples were collected and processed for analysis of the short-chain fatty acid.Results. Treatment with the pre-formulation decreased the clinical activity (bloody diarrhea), inflammatory infiltrate, and the ulcers. Pre-formulation did not repair the epithelial barrier and there were no significant differences in the goblet cells index. There was a significant difference in butyrate levels in the rats treated with the pre-formulation. Conclusions. The pre-formulation minimized the clinical symptoms of colitis and intestinal inflammation, but did not minimize damage to the intestinal barrier.

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The Anti-Inflammatory Potential of Mimosa caesalpiniifolia Following Experimental Colitis: Role of COX-2 and TNF-Alpha Expression

Cited by 7 publications

References 29 publications

A Comprehensive Review of the Ethnotraditional Uses and Biological and Pharmacological Potential of the Genus Mimosa

A Comprehensive Review of the Ethnotraditional Uses and Biological and Pharmacological Potential of the Genus Mimosa

Bioassay-Guided Isolation of Fungistatic Compounds from Mimosa caesalpiniifolia Leaves

Effects of Mimosa caesalpiniifolia pre-formulation on the intestinal barrier during sodium dextran sulfate-induced colitis in Wistar rats

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