2010
DOI: 10.1590/s0102-695x2010000400025
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Abstract: RESUMO:No Brasil as espécies de Mikania glomerata Spreng. e M. laevigata Sch. Bip. ex Baker, Asteraceae, popularmente conhecidas como guaco, são amplamente utilizadas com evidências pré-clínicas para o tratamento de doenças onde estejam envolvidas suas ações broncodilatadoras, antialérgicas, antiasmáticas, anti-inflamatórias, antiulcerogênicas e relaxantes da musculatura lisa. Em virtude das propriedades terapêuticas atribuídas as essas espécies, ambas foram oficializadas na farmacopéia brasileira, e por serem… Show more

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Cited by 47 publications
(38 citation statements)
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“…Phytochemical studies have shown that Mikania contains terpenes, essential oils 11 , di-and sesquiterpene lactones 12 , flavonoids, and stigmasterol 13 , alcohols, acids, esters, aldehydes, organic esters and steroids. Regarding the safety of the extracts, phytomedicines and isolated compounds, guaco species did not present significant toxic and genotoxic effects in humans 14 .…”
Section: Introductionmentioning
confidence: 90%
“…Phytochemical studies have shown that Mikania contains terpenes, essential oils 11 , di-and sesquiterpene lactones 12 , flavonoids, and stigmasterol 13 , alcohols, acids, esters, aldehydes, organic esters and steroids. Regarding the safety of the extracts, phytomedicines and isolated compounds, guaco species did not present significant toxic and genotoxic effects in humans 14 .…”
Section: Introductionmentioning
confidence: 90%
“…Diterpenes such as kaurenoic acid and benzoylgrandifloric acid (class of kauranes), have also attracted interest for their pharmacological action. Moreover, detailed screenings revealed the presence of other substances in species of Mikania as Review alcohols, acids, esters, aldehydes and organic esters (Gasparetto et al, 2010).…”
Section: Chemical Compositionmentioning
confidence: 99%
“…Although it is one of the most distinctive and easily recognized genera of the tribe, species delimitation is often difficult due to the very large number of taxa and the existence of highly polymorphic species complexes (King & Robinson, 1987). In Brazil, the genus with 171 species is mainly found in the states of São Paulo, Minas Gerais and Rio de Janeiro (Gasparetto et al, 2010). The species of this genus are characterized by herbaceous, annual or perennial (Pio Correa, 1984), and scandent habit, though there are as well commonly erect and decumbent representatives (Ritter & Miotto, 2005).…”
Section: Introductionmentioning
confidence: 99%
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“…Historicamente, as plantas são as fontes mais importantes para os produtos naturais 5 . O gênero Mikania, popularmente conhecido como guaco, tem sido associado às ações expectorante e antigripal 6 , alelopatia de sementes de alface 7 , ação anti-inflamatória 8 , além de atividades broncodilatadoras, antialérgicas, antiasmáticas, antiulcerogênicas e relaxantes da musculatura lisa 9 . No entanto, ressalta-se a importância de verificar outras atividades biológicas de M. glomerata Sprengel, assim como a cumarina -o principal metabólito encontrado no guaco, presente principalmente nas folhas.…”
Section: Introductionunclassified