Genus Mikania: chemical composition and phytotherapeutical activity

Rufatto, Luciane Corbellini; Gower, Adriana E.; Schwambach, Joséli; Moura, Sidnei

doi:10.1590/s0102-695x2012005000099

Cited by 53 publications

(47 citation statements)

References 107 publications

(115 reference statements)

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“…These findings agree with experimentally identified anti-inflammatory and antihemorrhagic properties of the Mikania genus against myotoxic, neurotoxic, and inflammatory effects of snake venoms [2]. The above observations are further supported by the findings of other studies in rats that revealed 80% reduction in hemorrhage area following intradermal injection of Bothrops venom and Mikania extract administration [14], and reduction of inflammatory cells, edema, and hemorrhagic halo 3 h after administration of B. jararaca venom and Mikania leaf extract [10].…”

supporting

confidence: 90%

“…Many plants have been used to ameliorate the effects of snakebite [1]. Among them, Mikania glomerata commonly known as "guaco," a plant found in the Brazilian Atlantic Forest, possesses multiple medical properties associated with its constituent coumarins and their derivativesterpenes, phytosterols, and flavonoids [14]. It may ameliorate the consequences of ophidic envenomation, probably through inhibition of phospholipase A2, metalloproteases, and serine proteases, which are enzymes associated with envenomation symptoms [2,9].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Mikania glomerata Leaf Extract on Experimental Bothropoides jararaca Envenomation in Wistar Rats

Motta

Nogueira

Floriano

et al. 2017

Acta Scientiae. Vet.

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Background: Bothropic envenomation represents the most common ophidic accident worldwide, compared to other snakebites of medical interest. Bothropic venom has proteolytic, vasculotoxic, clotting and/or hemorrhagic actions in animals and humans. Mikania glomerata is a plant found in the Brazilian Atlantic Forest with interesting medical properties that may be useful in ameliorating the effects of ophidic venom, and thus, improving response and outcome. Although Mikania is known to act through inhibition of cytolysins in the venom, there is a lack of consistent research data. The aim of this study was to evaluate the effect of M. glomerata in bothropic envenomation treatment. Materials, Methods & Results: Clinical, hematological, biochemical, and histopathological evaluations were performed following Bothropoides jararaca experimental envenomation in three groups of 18 Wistar rats each. Group VS was inoculated in the pelvic limb via intramuscular injection of bothropic venom and received specific anti-venom serum via intraperitoneal injection. Group VSM was similarly inoculated; it received anti-venom serum and a 10% aqueous extract of the Mikania glomerata plant orally. Group C was the control group and received saline solution alone. Evaluations were performed at 0.5 h (M1), 6 h (M2), and 24 h (M3) after venom inoculation. Animals from both inoculated groups (VS and VSM) showed significant clinical alterations (P < 0.05) manifested as discomfort, uneasiness, pain, and severe edema compared to control animals. Animals from inoculated groups also exhibited statistically significant leukocytosis with neutrophilia, and elevation of blood urea nitrogen and creatine kinase until 6 h after inoculation (P < 0.05 compared to control animals). An acute drop in body temperature was observed 6 h after inoculation (P < 0.05). High levels of creatinine were observed at 6 and 24 h, and plasma protein reduction at almost all evaluation time points (P < 0.05) in both groups compared to that in control. Histopathological evaluation of venom-inoculated animals (groups VS and VSM) showed significant renal hydropic degeneration, acute tubular necrosis, congestion, and hemorrhage (P < 0.05 compared to control). In contrast, animals administered plant extract in addition to anti-venom (group VSM) showed milder muscular fiber regeneration and absence of hemorrhage in the inoculated limb, compared to those that received anti-venom alone (group VS). Overall, there were no statistically significant differences between the inoculated groups (P > 0.05) in terms of edema reduction, pain relief, hematological, biochemical, or histopathological alterations. Discussion: Clinical envenomation symptoms can be explained based on previous reports of bothropic events, where cytolysins such as hyaluronidase, phospholipase A2, and esterases are associated with alterations in cell membrane permeability and release of vasoactive agents. Rhabdomyolysis and muscular necrosis are the main causes of muscular and renal alterations in inoculated grou...

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supporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Effects of Mikania glomerata Leaf Extract on Experimental Bothropoides jararaca Envenomation in Wistar Rats

Motta

Nogueira

Floriano

et al. 2017

Acta Scientiae. Vet.

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“…Coumarin, an active component found in guaco, is considered to be one of the main constituents responsible for its medicinal activity. It is also used as a chemical marker for ensuring quality control of products derived from guaco (Anvisa, 2005a;Ferreira and Oliveira, 2010;Rufatto et al, 2012). Drying of guaco is a preferred method for conserving the activity of its active ingredients and extending the shelf life to ensure a continuous supply to the phytotherapeutic industry.…”

Section: Introductionmentioning

confidence: 99%

EFFECT OF ETHANOL ON THE DRYING CHARACTERISTICS AND ON THE COUMARIN YIELD OF DRIED GUACO LEAVES (Mikania laevigata SCHULTZ BIP. EX BAKER)

Silva

Celeghini

Silva

2018

Braz. J. Chem. Eng.

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Guaco is a common medicinal plant in Brazil used for the treatment of respiratory diseases. Coumarin serves as a chemical marker for quality control of products derived from guaco. In this study, the drying kinetics and coumarin yield of guaco leaves dried with and without treating the surface with ethanol were evaluated. The drying experiments were carried out in a forced convection tunnel at 50 and 60 ºC temperatures and air velocities of 0.42 and 0.84 m/s. The results show that the samples with ethanol experienced faster water evaporation during drying experiments, thereby reducing the drying time by up to 35%, and also had higher yields of coumarin. Storage experiments and color analysis were also performed. Treatment of dried guaco leaves with ethanol resulted in color degradation, but increased shelf life by 20%.

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“…Its native distribution is in Central and South America. (2) Different parts of the plant Mikania micrantha are used to treat fever, jaundice, dysentery, rheumatism, colds, respiratory diseases and scorpion stings. (3) The leaves have been reported as good haemostatic agents.…”

mentioning

confidence: 99%

To Evaluate the Anti-Inflammatory Activity of Ethanolic Extract of Leaves of Mikania Micrantha on Experimental Animal Models

Deori¹,

Dutta²,

Das³

et al. 2017

jemds

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BACKGROUND Different parts of the plant Mikania micrantha are traditionally used to treat several diseases like dysentery, body sprain, diabetes, snake bites, itches, gout, flatulence, rheumatism and cancer. Therefore, the present study was undertaken to evaluate the antiinflammatory activity of the Ethanolic Extracts of leaves of Mikania micrantha (EEMM) on carrageenan-induced rat paw oedema, granuloma-pouch method and adjuvant-induced chronic arthritis on experimental animals. MATERIALS AND METHODSPlants of Mikania micrantha were collected from the campus of Assam Medical College, Dibrugarh, Assam. The extract of Mikania micrantha leaves was prepared by percolation method using 95% alcohol. Acute oral toxicity test of the extract was performed as per OECD 423 (OECD Guidelines, 2001). Acute inflammation was studied by carrageenan-induced rat paw oedema method; subacute inflammation was studied by Granuloma pouch method and chronic inflammation was studied by Freund's complete adjuvant-induced arthritis method. Aspirin 100 mg/kg was taken as a standard drug. A control group is maintained in all the above mentioned models. RESULTSThe results were analysed by ANOVA followed by Dunnett's multiple comparison test. EEMM in doses 200 -400 mg/kg produced dose dependent and significant (p < 0.05) reduction of paw oedema in carrageenan-induced acute and sub-acute inflammation in comparison to control. EEMM is not effective in chronic arthritis model in dose-dependent manner. CONCLUSIONThe present study indicates that EEMM has significant anti-inflammatory activity. The complete process of inflammation consists of three phases-(i) Dilatation and increased permeability of small blood vessels resulting in oedema and swelling; (ii) Emigration of leucocytes and cellular infiltration; and (iii) Proliferation of fibroblast and synthesis of new connective tissues. KEYWORDS

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Genus Mikania: chemical composition and phytotherapeutical activity

Cited by 53 publications

References 107 publications

Effects of Mikania glomerata Leaf Extract on Experimental Bothropoides jararaca Envenomation in Wistar Rats

Effects of Mikania glomerata Leaf Extract on Experimental Bothropoides jararaca Envenomation in Wistar Rats

EFFECT OF ETHANOL ON THE DRYING CHARACTERISTICS AND ON THE COUMARIN YIELD OF DRIED GUACO LEAVES (Mikania laevigata SCHULTZ BIP. EX BAKER)

To Evaluate the Anti-Inflammatory Activity of Ethanolic Extract of Leaves of Mikania Micrantha on Experimental Animal Models

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