Midazolams Cardiac Depressant Effects and Their Lack of Reversal by Flumazenil in Isolated Rabbit Hearts

Öztürk, Tülün; Tunçok, Yeşim; Kalkan, Şule; Guven, Hulya; Aran, Gülçin

doi:10.1006/phrs.1998.0444

Cited by 9 publications

(8 citation statements)

References 12 publications

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“…Although midazolam is to be considered among the benzodiazepines, which further reduce blood pressure [12,20], this was not observed in the KET group. However, pressure reduction occurred with the use of isoflurane, confirming literature reports [6,16], and with findings by Vasconcellos et al [26] in Cebus apella.…”

Section: Discussionmentioning

confidence: 93%

Evaluation of blood pressure in feline night monkeys (Aotus azarae infulatus) under different restraint protocols

Chaves

Souza

Imbeloni

et al. 2015

J of Medical Primatology

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Section: Discussionmentioning

confidence: 93%

Evaluation of blood pressure in feline night monkeys (Aotus azarae infulatus) under different restraint protocols

Chaves

Souza

Imbeloni

et al. 2015

J of Medical Primatology

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“…(2001) measured HR during KMZ anaesthesia in rabbits, and reported a reduction in HR from pre‐anaesthetic values of 260 bpm to minimum values of 220 bpm. Whilst direct application of large doses of midazolam on the myocardium of rabbits causes negative chronotropy, Ozturk et al. (1999) also reported that the cardiovascular effects would not normally be seen in clinical therapeutic doses, administered systemically.…”

Section: Discussionmentioning

confidence: 99%

A comparison of ketamine–midazolam and ketamine–medetomidine combinations for induction of anaesthesia in rabbits

Grint

Murison

2008

Veterinary Anaesthesia and Analgesia

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“…In the same year, Nonaka et al 19 , observed the negative inotropic effect of diazepam and midazolam in a culture of rats' cardiomyocytes. Ozturk et al 8 observed that midazolam, in doses ranging from 10mcg and 100mcg, have caused myocardium depression in rabbits. Medeiros et al 6 , studying the effects of diazepam, midazolam and propofol in isolated hearts of rats, reported that benzodiazepines have caused depression in myocardial contractility.…”

Section: Discussionmentioning

confidence: 99%

“…Hernández 4 , Pontes 5 , and Medeiros et al 6 demonstrated, in isolated hearts of rats, inhibition of the myocardial contractility after diazepam, midazolam and propofol infusion, and the depressive myocardial effect of midazolam was confirmed by Hekerdemian et al 7 and Ozturk et al 8 . The present study has the purpose to analyze the influence of midazolam in the ischemic preconditioning induced in isolated hearts of rats.…”

Section: Introductionmentioning

confidence: 92%

Preconditioning abolishion by midazolam in isolated hearts of rats

Gomes¹,

Valladares

Santos

et al. 2009

Acta Cir. Bras.

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Purpose:To study the effects of benzodiazepine midazolam in the coronary flow (Cflo), cardiac frequency (CF) and myocardial contractility in isolated hearts of rats subjected to ischemic preconditioning (IPC). Methods: 30 Wistar rats were used, undistinguished by gender. After anesthesia with ethyl ether, the hearts were put into perfusion (Krebs-Henseleit solution, 95% O 2 and 5% CO 2 , 37°C, 110-120mmHg), in disposable Langendorff type system. Five groups of six animals were constituted: GI-Control; GII-Ischemia; GIII-IPC; GIV-Ischemia + 100mcg of midazolam; GV-IPC + 100mcg of midazolam. After stabilization (t 0 ), and on times t 5 , t 10 , t 15 , t 20 and t 25 , CF, Cflo, systolic pressure (SP) and diastolic pressure (DP) and dP/dt were recorded. DP was maintained at 5 ± 2 mmHg. The statistical method ANOVA and Tukey Test were employed for p < 0.05. Results: No significant variations have occurred between Cflo and CF. On Pd/td, differences have occurred (p<0.05) between groups I and II (respectively 94.7±23.0 and 62.3±12.1%). The preconditioning (GIII), improved significantly the results in the group II (respectively 62.3±12.1 and 87.1±12.4 %). The decrease in dP/dt in group II was not prevented by midazolam (GIV) (62.3±12,1 and 60.5±15.8 %). In group III, dP/dt was 87.1±12.4%, whereas in group V, only 55.5±17.2% (p<0.05) Conclusion: Midazolam, when administered before the ischemia, was unable to prevent the ischemic deterioration of the myocardium. When administered before the preconditioning, it has abolished its protective effect. Key words: Ischemic Preconditioning. Heart. Midazolam. Rats. RESUMOObjetivo: Estudar os efeitos do benzodiazepínico midazolam no fluxo coronariano (Fco), freqüência cardíaca (FC) e contratilidade miocárdica de corações isolados de ratos submetidos ao precondicionamento isquêmico (PCI). Métodos: Foram utilizados 30 ratos Wistar sem distinção de sexo. Após anestesia com éter etílico, os corações foram postos em perfusão (solução de Krebs-Henseleit, 95% de O 2 e 5% de CO 2 , 37°C, 110-120mmHg), em sistema tipo Langendorff descartável. Foram constituídos cinco grupos de seis animais: GI-Controle; GII-Isquemia; GIII-PCI; GIV-Isquemia + 100mcg de midazolam ; GV-PCI + 100mcg de midazolam. Após estabilização (t 0 ), e nos tempos t 5 , t 10, t 15 , t 20 e t 25 , foram registrados a FC, Fco, pressões sistólica (PS) e diastólica (PD) e dP/dt. A PD foi mantida em 5 ± 2 mmHg. Empregou-se método estatístico ANOVA e Teste de Tukey para p < 0,05. Resultados: Não ocorreram variações significantes entre FCo e FC. Na dP/dt, ocorreram diferenças (p<0,05) entre os grupos I e II (respectivamente 94,7±23,0 e 62,3±12,1%). O precondicionamento (GIII), melhorou significantemente os resultados do grupo II (respectivamente 62,3±12,1 e 87,1±12,4 %). A queda da dP/dt no grupo II não foi impedida pelo midazolam (GIV) ( 62,3±12,1 e 60,5±15,8 %). No grupo III a dP/dT foi 87,1±12,4%, sendo que no grupo V, apenas 55,5±17,2% (p<0,05). Conclusão: O midazolan quando administrado antes da isquemia não impediu...

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Midazolams Cardiac Depressant Effects and Their Lack of Reversal by Flumazenil in Isolated Rabbit Hearts

Cited by 9 publications

References 12 publications

Evaluation of blood pressure in feline night monkeys (Aotus azarae infulatus) under different restraint protocols

Evaluation of blood pressure in feline night monkeys (Aotus azarae infulatus) under different restraint protocols

A comparison of ketamine–midazolam and ketamine–medetomidine combinations for induction of anaesthesia in rabbits

Preconditioning abolishion by midazolam in isolated hearts of rats

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