Metastatic renal cell carcinoma to the nose and paranasal sinuses

Renal cell carcinoma metastasis to the paranasal sinuses and orbit

“…The commonest neoplasms to metastasise to the head and neck region are breast and lung carcinoma followed by RCC 3 4. The commonest metastatic tumour to the paranasal sinuses is RCC, accounting for 49% of the cases, followed in order of frequency by bronchus, urogenital ridge, breast and gastrointestinal tract.…”

“…Characteristically, the tumour is slow-growing and encapsulated in its early stages and therefore may be asymptomatic until late stages 6. The initial classical presenting triad of haematuria, costovertebral pain and abdominal mass only occurs in 9% of the patients and in some cases sinonasal metastasis is the presenting feature 3. The clinical course of the primary tumours is often unpredictable.…”

Sinugene Metastasierung eines beidseitigen Nierenzellkarzinoms (Hypernephrom)

“…Alternative Therapieansätze stellen derzeit die Strahlen- [5,15,19] und die Immuntherapie [3,5,11,15,16] dar. Eine bilaterale Nephrektomie oder eine Resektion der Nasennebenhöhlenmetastase war wegen des fortgeschrittenen Stadiums nicht indiziert.…”

“…neoadjuvante Immuntherapie mit Interleukin-2 und Interferon-α eingesetzt [3,5,11,15,16]. B. Epistaxis, Nasenatmungsbehinderung oder periorbitale Schwellung wurde beobachtet [19]. Dieses Verfahren kann bei sinugener Metastasierung erfolgsversprechend mit einer palliativen perkutanen Radiatio des Lokalbefunds kombiniert werden.…”

Renal cell carcinoma metastases to the maxillary sinus

“…Renal cell carcinoma (RCC) accounts for about 85% of primary renal tumours1 and usually affects men aged between 30 and 60 years 2. Clear cell renal cancer is the most common histological subtype of RCC and accounts for 70%–80% of all RCCs 3.…”