Renal cell carcinoma metastasis to the paranasal sinuses and orbit

Evgeniou, Evgenios; Menon, Kavitha R; Jones, Graeme L; Whittet, Heiki; Williams, W J.

doi:10.1136/bcr.01.2012.5492

Cited by 18 publications

(23 citation statements)

References 22 publications

(26 reference statements)

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“…Postnephrectomy patients who develop a single metachronous metastasis may benefit from surgery and even aggressive surgical resection has been recommended . Several authors report successful treatment of solitary metastases with craniofacial resection .…”

Section: Primary Tumor Sitesmentioning

confidence: 99%

“…In a majority of cases, metastatic disease involves only one of the paranasal sinuses and the clinical presentation is similar to that of primary sinonasal tumors . Signs and symptoms are usually nonspecific and include recurrent epistaxis, nasal obstruction, and facial pain . Proptosis, diplopia, visual acuity impairment, and ptosis may also be presenting symptoms.…”

Section: Introductionmentioning

confidence: 99%

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Metastases to nasal cavity and paranasal sinuses

et al. 2016

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The sinonasal cavities are rare locations for metastases. Metastases to these locations are usually solitary and produce similar symptoms to those of a primary sinonasal tumor. Nasal obstruction and epistaxis are the most frequent symptoms. The maxillary sinus is most frequently involved. The most common primary tumor sites to spread to this region originate in the kidney, breast, thyroid, and prostate, although any malignancy could potentially lead to a metastasis to the paranasal sinuses. The patient's prognosis is usually poor because of the fact that the sinonasal metastasis is usually associated with widespread disseminated disease. In the majority of patients, palliative therapy is the only possible treatment option. Nevertheless, whenever possible, surgical excision either alone or combined with radiotherapy may be useful for palliation of symptoms and, rarely, to achieve prolonged survival. This review considers the most interesting cases reported in the literature that presents metastases to the sinonasal cavities. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1847-1854, 2016.

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Section: Primary Tumor Sitesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Metastases to nasal cavity and paranasal sinuses

et al. 2016

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“…The common presentation of RCC sinonasal metastasis comprises nasal obstruction, swelling, and pain. Approximately 46% of these patients complained of recurrent epistaxis due to highly vascular nature of RCC and its metastasis [5]. Identification of von Hippel-Lindau tumor suppressor (pVHL) considerably improved the understanding of RCC molecular biology.…”

Section: Discussionmentioning

confidence: 99%

Recurrent epistaxis as manifestation of renal cell carcinoma sinonasal metastasis

Folić¹,

Trivić²,

Pavlović³

et al. 2019

Srp Arh Celok Lek

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Introduction Renal cell carcinoma is the most frequent infraclavicular primary tumor metastasizing in the sinonasal region, although these metastases are not common. We present an unusual case of recurrent epistaxis as the initial sign of renal carcinoma sinonasal metastasis and discuss the diagnostic and treatment options. Case outline A 66-year-old patient was admitted to the hospital due to recurrent and severe epistaxis. The patient underwent nephrectomy due to renal cell carcinoma, with no signs of relapse during a three-year follow-up. Nasal endoscopy and computed tomography revealed a large mass in nasal cavity, spreading to the anterior and posterior ethmoid cells, sphenoid sinus, orbit, and anterior cranial fossa. Definite diagnosis of renal cell carcinoma metastasis in sinonasal region was made by a pathologist after biopsy and further radiological examination showed no signs of malignant disease in the abdomen, thorax, or pelvis. Although the patient had received 50 Gy of radiation therapy, the malignant disease was evaluated as progressive with further extension in anterior cranial fossa and maxilla, and the patient died five months after the occurrence of epistaxis. Conclusion In patients with recurrent epistaxis who also had a history of renal carcinoma, endoscopic finding of tumefaction in the nasal cavity should raise a suspicion of sinonasal metastasis. In such cases, biopsy is mandatory to differentiate a metastasis from primary sinonasal tumors. Histological confirmation should be followed by radiological examination of the abdomen, thorax, and pelvis to evaluate the possibility of renal cell carcinoma recurrence or metastatic dissemination elsewhere.

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“…Furthermore, in these not uncommon cases (relative frequency: 11% [1]), it also serves as a confirmation of the diagnosis [22,23], as demonstrated by our plasmacytoma (fig. 1a, b) and RCC-affected patients [24]. …”

Section: Discussionmentioning

confidence: 99%

The Role of Fine Needle Aspiration of Orbital Lesions: A Case Series

Pagni¹,

Jaconi²,

Smith³

et al. 2016

Acta Cytologica

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Objective: This paper analyzes a series of ultrasound (US)-guided orbital fine needle aspirations (FNAs) which provide diagnostic information that cytopathologists approaching orbital lesions for the first time can find useful and underlines the importance of teamwork. Study Design: The investigators retrospectively obtained data from 24 consecutive orbital FNAs. For all patients, a complete clinicoradiological database was created. FNAs were performed under US guidance with 25-gauge needles and an aspiration biopsy syringe gun, and sent to the Department of Pathology for examination and data management. Results: The mean age of the patients was 54 years. Imaging studies included US, magnetic resonance imaging and computed tomography scans; 9 lesions involved the right orbit and 15 the left orbit. The mean lesion size was 23.6 ± 7.2 mm. After microscopic examination, 7 smears were labeled as ‘nondiagnostic', while in 17 cases a definitive diagnosis was proposed, which always proved to be correct (70.8%, specificity = 100%). Conclusions: The investigators believe that FNA biopsy of orbital masses is a necessary step; its weaknesses lie in the particularly delicate site of sampling and the extreme heterogeneity of lesions. Nevertheless, when orbital FNA is performed within a well-coordinated multidisciplinary team, it is a powerful tool that can be used to define the most appropriate management of these patients.

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Renal cell carcinoma metastasis to the paranasal sinuses and orbit

Cited by 18 publications

References 22 publications

Metastases to nasal cavity and paranasal sinuses

Metastases to nasal cavity and paranasal sinuses

Recurrent epistaxis as manifestation of renal cell carcinoma sinonasal metastasis

The Role of Fine Needle Aspiration of Orbital Lesions: A Case Series

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