Metastases to nasal cavity and paranasal sinuses

López, Fernando; Devaney, Kenneth O.; Hanna, Ehab Y.; Rinaldo, Alessandra; Ferlito, Alfio

doi:10.1002/hed.24502

Cited by 47 publications

(56 citation statements)

References 136 publications

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“…Craniofacial resection or debulking with or without preoperative vascular embolization can be considered, however, the proximity of the metastatic tumor to the skull base may preclude surgical extirpation [59, 67, 69]. Radioiodine therapy, external beam radiation, chemotherapy, or palliative therapy can be considered in these patients [57, 59, 68, 74]. …”

Section: Discussionmentioning

confidence: 99%

Follicular thyroid carcinoma metastasis to the facial skeleton: a systematic review

et al. 2017

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BackgroundFollicular thyroid carcinoma (FTC) metastasis to the facial skeleton is exceedingly rare. A case of FTC metastasizing to the mandible is presented and a systematic review of the literature describing thyroid metastasis to the facial skeleton is performed.Case presentationA 73-year-old female presented with metastatic FTC to the mandible and underwent total thyroidectomy, segmental mandibulectomy, bone impacted fibular free flap reconstruction, and adjuvant radioactive iodine treatment. The PubMed database was searched for literature describing thyroid cancer with facial skeleton metastasis using the key words “thyroid,” “cancer,” “carcinoma,” “metastasis,” and “malignancy” with “oral cavity,” “maxilla,” “mandible,” “sinus,” “paranasal,” and “orbit.” Reports that only involved the soft tissues were excluded. Systematic review revealed 59 cases of well-differentiated thyroid cancer with facial skeleton metastasis: 35 mandibular metastases (21 = FTC), 6 maxilla metastases (2 = FTC), 9 orbital metastases (4 = FTC), and 11 paranasal sinus metastases (7 = FTC). Treatment included surgery, RAI, external beam radiotherapy (XRT), or a combination of these modalities. The one, two, and five-year survival rates were 100%, 79%, and 16%, respectively.ConclusionFacial skeleton metastasis of FTC is a rare clinical challenge. Optimal treatment appears to include total thyroidectomy and resection of involved structures with or without adjuvant treatment.

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Section: Discussionmentioning

confidence: 99%

Follicular thyroid carcinoma metastasis to the facial skeleton: a systematic review

et al. 2017

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“…It is therefore important to distinguish between both conditions, though this may be challenging. Both primary malignancy and metastatic malignancy can present with recurrent epistaxis, nasal obstruction and facial pain [1,2]. Secondly, the histology of colonic metastases to the nasal cavity is indistinguishable from primary sinus adenocarcinomas-more specifically the colonic variant of ITAC [3].…”

Section: Discussionmentioning

confidence: 99%

“…The development of nasal metastases from colorectal cancer is associated with poor outcomes, with none of the case reports surviving past the five-year mark from the diagnosis of the nasal metastases. All cases were treated with palliative radiotherapy to the nasal region [2,3,8].…”

Section: Discussionmentioning

confidence: 99%

Nasal Cavity Metastasis From Colorectal Cancer Represents End-Stage Disease and Should Be Palliated

et al. 2020

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Nasal metastases from colorectal cancer is rare. The presentation of nasal metastases is often very similar to primary nasal sinus adenocarcinoma. A high index of suspicion is required, especially in patients who have had a previous history of colorectal carcinoma. Histology is ultimately required for diagnosis. We describe 2 cases of nasal metastases from colorectal carcinoma, and discuss the presentation, diagnosis and management of the case. Such metastatic disease ultimately represents end-stage malignancy, and patients should be palliated.

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“…The spread of metastases around the body can follow either a haematogenous or lymphogenous route 13. One such postulated haematogenous route is via the vertebral venous plexus (Batson plexus).…”

Section: Discussionmentioning

confidence: 99%

Small cell lung cancer presenting as unilateral rhinorrhoea

Haymes¹,

Mahalingam

Choudhury

2017

BMJ Case Reports

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The metastatic spread of infraclavicular malignancies to the nasal cavity is rare. We describe the case of a 58-year-old man who presented with a 4-month history of right-sided rhinorrhoea, maxillary hypoesthesia, hyposmia and hypogeusia. Clinical examination revealed an irregular mass within the right nasal cavity. Immunohistochemical analyses of biopsies were consistent with small cell carcinoma of indeterminate origin. A positron emission tomography scan demonstrated extensive mediastinal lymphadenopathy with collapse-consolidation of the right lung's middle lobe and no other sites of metastasis. Following discussion at the lung multidisciplinary team meeting, a diagnosis of metastatic small cell lung cancer (SCLC) was made; the patient was staged with N3, M1b disease and palliative chemo-radiotherapy was started. To the best of our knowledge, this report represents the first documented case of a solitary nasal cavity metastasis arising from a SCLC.

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Metastases to nasal cavity and paranasal sinuses

Cited by 47 publications

References 136 publications

Follicular thyroid carcinoma metastasis to the facial skeleton: a systematic review

Follicular thyroid carcinoma metastasis to the facial skeleton: a systematic review

Nasal Cavity Metastasis From Colorectal Cancer Represents End-Stage Disease and Should Be Palliated

Small cell lung cancer presenting as unilateral rhinorrhoea

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