Nasal Cavity Metastasis From Colorectal Cancer Represents End-Stage Disease and Should Be Palliated

Hwang, Stephen W.; Chan, Dedrick Kok Hong; Petersson, Fredrik; Tan, Ker‐Kan

doi:10.3393/ac.2019.03.04

Cited by 6 publications

(2 citation statements)

References 7 publications

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“…On the contrary, nasal metastases from colorectal primary carry a very poor prognosis and are usually fit for palliative treatment only. [9] Hence, differentiating between the two becomes very important. Due to the rarity of such cases, this case may help throw light on the importance of clinical, radiological, histopathological, and immunohistochemical features in diagnosing a nasal cavity mass in a pre-existing rectal adenocarcinoma as primary or metastatic.…”

Section: Resultsmentioning

confidence: 99%

A Very Rare Case of Metastases to the Nasal Cavity from Primary Rectal Adenocarcinoma

Lohia¹,

Sadashiva²,

Singh³

et al. 2022

Clin Cancer Investig J

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Nasal cavity as the first site of metastases from colorectal adenocarcinoma without metastases elsewhere is generally unheard of and very rare with only a few cases reported in world literature. The diagnostic dilemma and therapeutic challenge are significant when encountered in clinical practice, especially to differentiate it from a primary nasal pathology. Histopathological examination and immunohistochemistry play an important role. We report an unusual and interesting case of adenocarcinoma rectum with nasal metastases. A 65-year-old male was treated for adenocarcinoma rectum with radiotherapy, surgery and chemotherapy and was disease-free for 9 months post-treatment completion. Subsequently, he presented with nasal bleeding and on evaluation was found to have a nasal mass. Histopathological examination and immunohistochemistry confirmed the mass to be a metastasis from the earlier rectal adenocarcinoma. He received palliative haemostatic radiotherapy for bleeding from the nasal mass and was then treated with 6 cycles of 5-fluorouracil and irinotecan-based palliative chemotherapy. The patient achieved a good level of palliation, had near-complete regression of nasal mass on imaging with no new sites of metastases and hence was placed on regular follow up.

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Section: Resultsmentioning

confidence: 99%

A Very Rare Case of Metastases to the Nasal Cavity from Primary Rectal Adenocarcinoma

Lohia¹,

Sadashiva²,

Singh³

et al. 2022

Clin Cancer Investig J

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“…It is reported that increased numbers of metastatic lesions and peritoneal involvements are associated with a poor prognosis of survival. In addition, tumor subtypes based on microsatellite instability and genetic alterations in KRAS, NRAS, or BRAF are crucial in understanding the biologic features of primary cancer and metastatic lesions [9]. With the development of molecular targeted agents and surgical techniques, multimodal treatments of mCRC have been advanced to improve survival and increase the efficacy of treatment [10].…”

Section: Introductionmentioning

confidence: 99%

Recent Advance in the Surgical Treatment of Metastatic Colorectal Cancer-An English Version

Park

Baik

2022

J Anus Rectum Colon

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Stage IV colorectal cancer (CRC) has heterogeneous characteristics in tumor extent and biology. The overall survival of patients with metastatic CRC has improved with the development of multimodal treatments and new chemotherapeutic drugs. Resection of metastatic CRC is performed for liver, lung, or peritoneal metastases. Conversion surgeries to resect oligometastatic lesions have been developed with tumor regression using chemotherapeutic agents. Two-stage hepatectomy has extended the surgical indications for patients with metastatic CRC. Synchronous liver and primary tumor resection can be considered in patients with adequate conditions. Local ablation with radiotherapy can be used to treat lung metastasis. In the treatment of patients with CRC with peritoneal metastasis, cytoreductive surgery with hyperthermic intraperitoneal chemotherapy can be considered. Surgical treatments should be performed in patients with symptomatic primary tumors with unresectable metastasis. However, primary tumor resection in patients with asymptomatic CRC with synchronous, unresectable metastases did not show overall survival benefits in recent studies. Therefore, the treatment of metastatic CRC is challenging due to the variable tumor extent and heterogenous characteristics. Tailored surgical treatments and multidisciplinary approaches may improve survival and the quality of life in patients with metastatic CRC.

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Metastatic sinonasal malignancies of colorectal origin: Case report and comprehensive review of the literature

Rothka,

Goldrich,

Lighthall

2024

Clinical Case Reports

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Nasal Cavity Metastasis From Colorectal Cancer Represents End-Stage Disease and Should Be Palliated

Cited by 6 publications

References 7 publications

A Very Rare Case of Metastases to the Nasal Cavity from Primary Rectal Adenocarcinoma

A Very Rare Case of Metastases to the Nasal Cavity from Primary Rectal Adenocarcinoma

Recent Advance in the Surgical Treatment of Metastatic Colorectal Cancer-An English Version

Metastatic sinonasal malignancies of colorectal origin: Case report and comprehensive review of the literature

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