One hundred and forty-three patients with post-cricoid squamous cell carcinoma are described. Twenty-nine patients (20%) underwent pharyngolaryngoesophagectomy with gastric transposition. Forty-four patients (31%) were treated with radical radiotherapy and 70 (49%) had palliative therapy. Kaplan Meier 5-year survival following surgery was 45% and radiotherapy was 23%. The presence of nodal disease at presentation was the most significant prognostic factor. The 5-year survival of patients undergoing surgery with no palpable lymph node spread at presentation was 63% which compared with 25% following radiotherapy. This difference was statistically significant (P = 0.0153, Logrank test stratified by nodal status). Patients with palpable metastatic nodal spread at presentation had 5-year survivals of 10% and 0% in the surgical and radiotherapy groups respectively. This study demonstrates that patients with post-cricoid carcinoma who present without palpable lymph node spread have a significant improved 5-year survival following surgery when compared with radiotherapy.
This is a repository copy of Quantification of the influence of NO2, NO and CO gases on the determination of formaldehyde and acetaldehyde using the DNPH method as applied to polluted environments.
Chronic leg ulceration is a major health problem in the UK costing the NHS up to £600 million per annum. In Western countries, 1–2% of the population is likely to have a chronic leg ulcer at any one time; this increases to 3% in those over 65 years old. Studies have found that 60–80% of chronic leg ulcers have a venous component and 10–30% are associated with arterial insufficiency. The natural history of the disease is a continuous cycle of breakdown and healing over decades. As a result, ulcer healing rates can be poor with up to 50% of venous ulcers open and unhealed for 9 months. Most of the clinical management falls to primary care with over 80% of leg ulcer cared for in the community.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.