Metastatic renal cell carcinoma to the nose and paranasal sinuses

Simó, Ricard; Sykes, Andrew J; Hargreaves, Simon P.; Axon, Patrick; Birzgalis, A. R.; Slevin, Nicholas J; Farrington, W. T.

doi:10.1002/1097-0347(200010)22:7<722::aid-hed13>3.0.co;2-0

Cited by 75 publications

(60 citation statements)

References 16 publications

(25 reference statements)

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“…On the other hand, Azam et al and Simo et al have suggested the effectiveness of radiotherapy in the treatment of metastatic disease to achieve local control and for palliative management [11,15]. Chemotherapeutic agents such as vinblastine have been proved ineffective in the treatment of advanced RCC, with a response rate lower than 10%.…”

Section: Discussionmentioning

confidence: 99%

Lingual metastasis as an initial presentation of renal cell carcinoma

et al. 2010

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Distant metastasis of malignant neoplasm to the oral soft tissue is extremely rare. We report a case of renal cell carcinoma (RCC) metastasizing to the tongue. A 47-year-old man visited our hospital with chief complaint of a lump on the middle third of the dorsum of his tongue, and the lesion fell off from the tongue. Although histopathological diagnosis of the mass was granuloma teleangiecaticum, similar nodule reappeared in the same area 2 weeks later. The second lesion was composed of granuloma teleangiectaticum and aggregation of neoplastic clear cells in ductal arrangement. The clear cells were immunohistochemically positive for EMA and CD10.The abdominal CT scan revealed a 5.5 cm mass in the left kidney, suggesting RCC.Thus the lingual lesion was consistent with metastaic RCC. There has been no recurrence for 2 years after the radical nephrectomy and local exicision of the tongue.

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Section: Discussionmentioning

confidence: 99%

Lingual metastasis as an initial presentation of renal cell carcinoma

et al. 2010

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“…8 Metastases commonly occur, with about 40% of patients presenting with metastatic disease. The most frequent metastatic sites are lung (76%), regional lymph nodes (66%), bone (42%), and liver (41%).…”

Section: Discussionmentioning

confidence: 99%

Ocular Metastasis as First Presentation of Renal Cell Carcinoma: Report of 2 Cases

Pompeu¹,

Arap²,

Silva³

et al. 2005

Clinics

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POMPEU ACL et al. Ocular metastasis as first presentation of renal cell carcinoma: Report of 2 cases. CLINICS 60(1): [75][76][77][78] 2005.Authors report the cases of 2 patients who had an ocular lesion as the first sign leading to diagnosis of renal cell carcinoma, an uncommon presentation of this neoplasm.The first patient was a 59-year-old man presented with a mass in the right eye. The histological and immunohistochemical profile of the biopsy showed a probable renal cell carcinoma. A CT scan showed a solid mass in the left kidney. The patient underwent radical nephrectomy and excision of the ocular lesion and had an uneventful evolution. The second patient was a 72-year-old man presenting with an ulcerated lesion on the right inferior tarsal conjunctiva. An excisional biopsy of the lesion showed histological and immunohistochemical patterns of a clear cell carcinoma. Abdominal tomography disclosed a right peripheral renal tumor. A right radical nephrectomy was performed.Renal cell carcinoma may present atypically with metastases to quite uncommon organs. Nephrectomy may be of value in selected cases; the ocular metastases are usually excised for aesthetic and functional reasons. LETTER TO THE EDITORSRenal cell carcinoma accounts for approximately 85% of primary renal neoplasms, 1 and represents approximately 3% of all adult malignancy. 2 The most common sites of metastasis are lung (50%) and bone (33%), but renal cell carcinoma has been documented to metastasize to every organ and site in the body. Only rarely does it metastasize to the eye and orbit, occasionally mimicking other lesions. Moreover, considering all metastatic neoplasms in the eye, only a minority is due to renal cell carcinoma, as demonstrated in a pathology survey where only 7 out of 196 cases of ocular metastatic carcinoma originated from renal cell carcinomas. 4 Ocular metastases from renal cell carcinomas are most like to involve the iris, 5 ciliary body, 6 and choroids, although eyelid and orbital metastases have been described. 7 Our aim is to report 2 cases of patients who had an ocular lesion as the first sign leading to diagnosis of renal cell carcinoma. CASE 1A 59-year-old man presented to the outpatient ophthalmology department of our hospital in June 2003 with a 3-month history of diplopia and a mass in the right eye. His medical history was significant only for hypertension. Upon examination, a conjunctival lesion and proptosis were found (Figure 1). A CT scan and an ocular ultrasound examination revealed a retroocular mass inferior to the optical nerve. The diagnostic impression on clinical and radiological findings was of a probable metastatic neoplasm. A thoracic CT scan revealed multiple nodular lesions, and an abdominal ultrasound showed a mass in the inferior pole of left kidney and subhepatic lymphadenopathy. The results of complete blood count, electrolytes, liver function tests,

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“…(2) However, patients with a solitary metastasis treated with surgery have been reported to have a two-year survival rate of 41% and a five-year survival rate of 13%. (7) In summary, metastatic deposits of RCC are very rare in the nose and paranasal sinuses. We herein presented the case of a patient with recurrent epistaxis who was diagnosed with metastatic deposits of ccRCC in the paranasal sinuses ten years after curative nephrectomy.…”

Section: Case Reportmentioning

confidence: 98%

Nephrogenic epistaxis

Kumar¹,

Sikka²,

Kumar³

et al. 2014

smedj

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Metastatic renal cell carcinoma (RCC) in the nose and paranasal sinuses is very rare. We report an unusual case of metastatic RCC that presented as recurrent epistaxis ten years after curative nephrectomy. The purpose of this report is to draw the attention of clinicians to the possibility of metastatic RCC in patients with recurrent epistaxis and nasal mass. We also discuss treatment options and review the relevant literature.

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Metastatic renal cell carcinoma to the nose and paranasal sinuses

Cited by 75 publications

References 16 publications

Lingual metastasis as an initial presentation of renal cell carcinoma

Lingual metastasis as an initial presentation of renal cell carcinoma

Ocular Metastasis as First Presentation of Renal Cell Carcinoma: Report of 2 Cases

Nephrogenic epistaxis

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