2014
DOI: 10.11622/smedj.2013185
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Nephrogenic epistaxis

Abstract: Metastatic renal cell carcinoma (RCC) in the nose and paranasal sinuses is very rare. We report an unusual case of metastatic RCC that presented as recurrent epistaxis ten years after curative nephrectomy. The purpose of this report is to draw the attention of clinicians to the possibility of metastatic RCC in patients with recurrent epistaxis and nasal mass. We also discuss treatment options and review the relevant literature.

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Cited by 5 publications
(3 citation statements)
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“…RCC can metastasize early, and symptoms of a metastatic tumor may be the first clinical presentation . Alternatively, sinonasal RCC metastases may occur many years (up to 18) after treatment of the primary tumor . Sinonasal metastasis is usually associated with metastasis to other organs and single head and neck metastasis from RCC is an exceptional occurrence…”
Section: Primary Tumor Sitesmentioning
confidence: 99%
“…RCC can metastasize early, and symptoms of a metastatic tumor may be the first clinical presentation . Alternatively, sinonasal RCC metastases may occur many years (up to 18) after treatment of the primary tumor . Sinonasal metastasis is usually associated with metastasis to other organs and single head and neck metastasis from RCC is an exceptional occurrence…”
Section: Primary Tumor Sitesmentioning
confidence: 99%
“…Metastatic RCC to the sinonasal district has been reported as the presenting sign of this disease in a few cases [ 29 , 34 ], while in others it followed or occurred simultaneously to primary cancer diagnosis. Presentation symptoms are often limited to recurrent epistaxis [ 40 – 43 ] and the presence of a primary renal cell carcinoma is recognized only after surgical removal of the metastatic tumor via histologic examination supported by immunohistochemical staining of the specimen [ 5 ]. Rarely, metastasis in the sinonasal cavities followed RCC diagnosis and treatment [ 44 – 46 ]; cases of postsurgery metastasis in the head and neck district have been described up to 12 years after surgery [ 47 ].…”
Section: Discussionmentioning
confidence: 99%
“…Very rarely, epistaxis may also be neoplastic, such as metastatic renal cell carcinoma. [14]. Age of patients uses drugs that affect the blood coagulation system.…”
Section: Etiologymentioning
confidence: 99%