Lingual metastasis as an initial presentation of renal cell carcinoma

Ahn

Clin Exp Otorhinolaryngol

et al. 2014

Primary lung adenoid cystic carcinoma (ACC) is extremely rare and accounts for approximately 0.1%-0.2% of all lung cancers. ACC of the head and neck has generally been regarded as a slow-growing, low-grade malignancy which has a tendency for local recurrence and frequent distant metastasis. When ACC of the lung is identified, physicians must determine whether it represents distant metastasis or a primary lung cancer. Thyroid transcription factor-1 staining is one of the most useful methods to differentiate primary from metastatic lesions in lung cancer. Herein we report a case of metachronous, not synchronous, ACC at the peripheral lung followed by ACC presentation at the base of the tongue, and review of relevant literatures.

Section: Discussionsupporting

confidence: 49%

Metachronous Adenoid Cystic Carcinoma in the Peripheral Lung and at Base of the Tongue

Ahn

Clin Exp Otorhinolaryngol

et al. 2014

J Int Soc Prevent Communit Dent

“…the tongue is a frequent site for Renal Cell Carcinoma metastasis and usually indicates a widespread disease. [51] In the present series, there were 58 cases of metastasis from the kidney, and in 19 cases the tongue was the metastatic site. The second most common primary site metastasized to the tongue was the lung with 11 cases.…”

Section: Discussionmentioning

confidence: 61%

Metastasis to the oral soft tissues: A review of 412 cases

Irani

2016

The present review article analyzes the characteristics of metastases to the oral soft tissues from 1937 to 2015. An extensive literature search was performed. All variables such as age, gender, and primary and secondary tumor sites were analyzed. Metastases to the major salivary glands were not included in this review. In general, there were 412 metastatic lesions developed in the oral soft tissues. The male-to-female ratio was approximately 1.8:1. The mean age of the patients at diagnosis was 58. The lung was the most common primary site and the gingiva was the most common metastatic site. The greater part of the histological examination yielded adenocarcinoma. The diagnosis of a metastatic lesion in the oral cavity is a challenge to the clinicians due to the lack of pathognomonic signs and symptoms. Oral metastases usually occur in the advanced stages of cancers, and the interval between appearance and death is usually short. The oral soft tissue metastasis can be easily recognized compared to the metastasis of jawbones. Early detection of oral lesions is important in the case of being the first sign of a malignancy in other parts of body.

“…Regarding treatments, surgery is often recommended due to the ability of metastatic RCC to resist radiotherapy and pharmacotherapy, including chemotherapy, molecularly targeted therapy, or immunotherapy [40]. However, oral metastasis of renal cancer has a poor prognosis, and hemostasis is di cult during surgery.…”

Section: Discussionmentioning

confidence: 99%

Renal Cell Carcinoma Metastasis to the Maxillary Bone: A Case Report and Review of the Literature

Nishii¹,

Shiba²,

Ohsako³

et al. 2020

Preprint

Self Cite

Background: Metastasis of renal cell carcinoma (RCC) to the oral cavity is rare. Given the poor prognosis of metastatic RCC, treatment choice is difficult. Here, we report a case of RCC metastasis to the maxillary bone, and provide a detailed literature review regarding the patient characteristics, treatments and outcomes of RCC metastasis to the oral cavity.Case presentation: An 89-year-old Japanese man presented with an 8 × 8-mm granulomatous tumor with palpable pulsation in the left upper gingiva, which had been clinically suspected as an arteriovenous malformation. The patient had undergone left nephrectomy for clear cell carcinoma 7 years prior. Pulmonary metastasis had appeared 3 years later. The patient underwent tumor resection of the maxilla after intravascular embolization, and the tumor was histopathologically diagnosed as a metastasis of clear cell RCC to the maxillary bone. Seventeen months after surgery, he died because of pulmonary metastasis without evidence of recurrence in the oral cavity.Conclusion: Our literature review reveals that oral metastatic lesions of renal cancer often exhibit rapid enlargement and cause severe symptoms, such as dysphagia and bleeding. Although oral metastasis of RCC has a poor prognosis due to the presence of concurrent disseminated metastases, surgical therapy may be recommended because of its high local control rate and ability to maintain quality of life.