A comparison of surgery and radiotherapy in the management of post-cricoid carcinoma

Axon, Patrick; Woolford, T. J.; Hargreaves, Simon P.; Yates, Paul; Birzgalis, A. R.; Farrington, W. T.

doi:10.1046/j.1365-2273.1997.t01-1-00008.x

Cited by 30 publications

(36 citation statements)

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“…Citing its propensity for submucosal spread, other reports have also shown advanced stage at presentation to be common, 52% to 80% classified as cT3 or cT4 . Although studies from England and India have found a greater proportion of cases in females (50%–90%), we found Caucasian males to be most frequently affected in the United States.…”

Section: Discussioncontrasting

confidence: 69%

“…Malignancy of the posterior cricoid is rare, accounting for 1.8% of all hypopharyngeal cancers in the NCDB. Studies addressing posterior cricoid SCC treatment largely have been conducted outside the United States, mostly during the 1980s when management was different from today . More recent literature from within the United States has focused on hypopharyngeal carcinoma as a whole.…”

Section: Discussionmentioning

confidence: 99%

“…Posterior cricoid squamous cell carcinoma (SCC) is rare, accounting for only 2% to 13% of cancers within the hypopharynx . The majority of literature on the subject comes from over two decades ago, when treatment paradigms were much different from today . Furthermore, these reports took place in large academic institutions outside the United States.…”

Section: Introductionmentioning

confidence: 99%

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Predictors of survival in posterior cricoid squamous cell carcinoma: A study of 248 cases

et al. 2016

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Section: Discussioncontrasting

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Predictors of survival in posterior cricoid squamous cell carcinoma: A study of 248 cases

et al. 2016

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“…The standard treatment of advanced hypopharyngeal cancer is surgery and postoperative radiotherapy (Vandenbrouck et al 1977;Pingree et al 1987;Frank et al 1994;Axon et al 1997;Hoffman et al 1997;Eckel et al 2001), while chemoradiotherapy aimed at larynx-preservation has recently been reported (Kraus et al 1994;Clayman et al 1995;Lefebvre et al 1996;Zelefsky et al 1996;Samant et al 1999). Not all patients with hypopharyngeal cancer are treated by surgery for various reasons such as unresectable primary cancer or lymph node metastasis, patient refusal, and severe cardiopulmonary disorder (Eckel et al 2001).…”

Section: Discussionmentioning

confidence: 99%

“…Not all patients with hypopharyngeal cancer undergo radical treatment. Although there are many reports concerning each radical treatment (Pingree et al 1987;Ho et al 1993;Frank et al 1994;Spector et al 1995;Axon et al 1997;Eckel et al 2001;Godballe et al 2002;Barzan et al 2002), general results of the treatment of hypopharyngeal cancer are unclear. Therefore we analyzed the results of treatment in 74 patients with hypopharyngeal cancer retrospectively to clarify each problem, and herein discuss appropriate treatment strategies for future prospect.…”

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confidence: 99%

Management of the Patients with Hypopharyngeal Cancer: Eight-Year Experience of Miyagi Cancer Center in Japan

Tateda

Shiga

Yoshida

et al. 2005

Tohoku J. Exp. Med.

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The aim of this study is to evaluate the results of treatment for hypopharyngeal cancer and indicate the future prospect of the treatment. Seventy-four patients with squamous cell carcinoma of the hypopharynx admitted to Miyagi Cancer Center from 1993 through 2000 are reviewed. Sixty-four patients received radical treatment, and 10 patients received palliative treatment or no treatment. The cancer was advanced (stages III and IV) in 82% of all the patients. The overall 5-year survival rate of all the patients was 38%. The overall 5-year survival rate of 64 patients received radical treatment was 43%. The ten patients who received palliative treatment or no treatment died of cancer within 16 months. Fifty-two out of the 74 patients underwent neck dissection for the neck lymph node involvement; forty of the 52 patients underwent ipsilateral neck dissection and 12 underwent bilateral neck dissection. Four out of the 40 patients, who underwent ipsilateral neck dissection alone, developed late contralateral regional recurrence but were successfully treated by contralateral neck dissection at the time of recurrence. Twenty-three out of 74 patients had multiple primary cancers synchronously or metachronously (31%). Cause of the death of six patients out of 74 patients was confirmed to be primary cancers other than hypopharyngeal cancer, as judged by physicians in other department or other hospitals. Most of the patients died due to distant metastasis from hypopharyngeal cancer or other primary cancers. We therefore conclude that contralateral elective neck dissection which is frequently chosen for the treatment of hypopharyngeal cancer surgery is unnecessary. Even if locoregional control is accomplished, distant metastasis or multiple primary cancers emerge and make prognosis poor. To improve the prognosis, we should develop some strategy against hypopharyngeal cancer for each patient. New strategies including chemoprevention and surgery against distant metasistasis are necessary.hypopharyngeal cancer; distant metastasis; multiple primary cancers; elective neck dissection

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Surgical Management of Carcinoma of the Hypopharynx and Cervical Esophagus

Triboulet

Mariette²,

Chevalier³

et al. 2001

Arch Surg

198

187

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Background: Free jejunal transfer has become the standard technique for reconstruction of the pharynx and hypopharynx, especially with proximal neoplastic lesions, whereas gastric tube interposition is the technique of choice for reconstruction of the hypopharynx and cervical esophagus when resection extends below the thoracic inlet. Hypothesis: Surgical ablation is a viable option for advanced hypopharyngeal and cervical esophageal neoplasms, with stomach interposition a safe and preferred method of reconstruction. Design: Retrospective analysis. Setting: University hospital that is a regional referral institution for esophageal cancer treatment and complex digestive reconstructions after esophagectomy. Patients: We reviewed the records of 209 patients who underwent total pharyngolaryngectomy between May 1982 and July 1999. The majority of patients had advanced cancer: hypopharyngeal in 131 cases and cervical esophageal in 78 cases. Interventions: Pharyngolaryngectomy and total esophagectomy with pharyngogastric anastomoses (n=127); pharyngolaryngectomy, cervical esophagectomy, and reconstruction with free jejunal transplant (n =77); and pharyngolaryngectomy and total esophagectomy with pharyngocolic anastomoses (n = 5). Main Outcome Measures: Postoperative mortality and morbidity, long-term survival, and prognostic factors influencing survival. Results: The postoperative in-hospital mortality rate was 4.8% (10 patients), with a postoperative morbidity rate of 38.3%. Alimentary continuity was achieved using the stomach (127 patients), colon (5 patients), or free jejunal autograft (77 patients). The 1-year and 5-year survival rates were 62% and 24%, respectively. There was no significant difference with regard to the survival between gastric transposition and free jejunal autograft, but there were fewer complications in the gastric pull-up group (33% vs 47%, PϽ.05). The significant adverse factors affecting survival were tumor cervical localization, postoperative complications, disease stages pT3 and pT4 for the cervical esophageal tumors, microscopic pharyngeal penetration, or incomplete resection. The significant beneficial factors were tumor hypopharyngeal localization and postoperative radiotherapy. Conclusions: Surgical ablation is a viable option for advanced hypopharyngeal and cervical esophageal neoplasms, with stomach interposition the preferred method of reconstruction. Although the prognosis is poor, satisfactory short-term palliation can be achieved. The significant adverse factors affecting survival should be taken into account to select the candidates for surgery.

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A comparison of surgery and radiotherapy in the management of post-cricoid carcinoma

Cited by 30 publications

References 0 publications

Predictors of survival in posterior cricoid squamous cell carcinoma: A study of 248 cases

Predictors of survival in posterior cricoid squamous cell carcinoma: A study of 248 cases

Management of the Patients with Hypopharyngeal Cancer: Eight-Year Experience of Miyagi Cancer Center in Japan

Surgical Management of Carcinoma of the Hypopharynx and Cervical Esophagus

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